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Southern Africa is the epicentre of the HIV/AIDS epidemic, with some of the largest antiretroviral therapy (ART) programmes worldwide. By June 2015, UNAIDS estimated 15.8 million people had started ART, 3 million in South Africa alone.

The International epidemiologic Databases to Evaluate AIDS Southern Africa collaboration (IeDEA-SA) undertakes research to improve the long-term delivery of HIV care and ART services. The combined database includes individual-level data on more than 640,000 adults and children on ART in 16 large collaborating cohorts in Malawi, Zambia, South Africa, Mozambique, Lesotho and Zimbabwe.