Large private managed-care HIV programme for employed people in Southern Africa which has 220,000 enrolled patients. Patients are treated by private medical practitioners. AfA contracts directly with companies or medical insurance companies to administer HIV care. Site investigator: Gary Maartens

CIDRZ is the largest nonprofit healthcare research organization in Zambia and has an extensive technical and support infrastructure to facilitate ongoing healthcare, research, and training activities. CIDRZ contributes data to IeDEA-SA from 77 clinics to which it provides support. Site investigator: Michael Vinikoor

The Hannan Crusaid Treatment Centre at the Gugulethu Community Health Centre is a large ART service in Gugulethu, with more than 7500 children, adolescents, and adults currently accessing care. Gugulethu is an urban suburb of Cape Town in the Western Cape of South Africa and was one of the first public sector ART programs in South Africa, providing care since 2002. Site investigator: Robin Wood.

Harriet Shezi Paediatric ARV Clinic at Chris Hani Baragwanath Hospital in Soweto is one of the largest clinics of its kind in South Africa. It started in 2002 as a pediatric HIV ART initiation and HIV care site and has evolved into a tertiary level HIV clinic supporting all of Region D and Region G in Johannesburg. Site investigator: Nosisa Sipambo

The KwaZulu-Natal Research Institute for TB-HIV (K-RITH) and Africa Centre for Population Health have joined to form an exciting new interdisciplinary research institute, called the Africa Health Research Institute. The aim is to become a source of fundamental discoveries into the susceptibility, transmission and cure of HIV and TB and related diseases, seeking always to improve diagnosis, prevention and treatment.
The new organisation, the Africa Health Research Institute, is located at the heart of South Africa’s TB and HIV co-epidemic. It combines the renowned Africa Centre for Population Health’s detailed population data from over 100 000 participants, with the KwaZulu-Natal Research Institute for TB-HIV’s (K-RITH’s) basic science, experimental medicine and world-class laboratory facilities. Site Investigator: Frank Tanser

The Khayelitsha ART service, situated in the Western Cape Province, began in 2001 as one of the pioneering primary care ART programs in South Africa. By 2014, this urban cohort has enrolled more than 40 000 patients on ART across 11 facilities within the Khayelitsha township. Today, the ART services are run by two local authorities (Provincial Department of Health and Metropolitan City Health directorate), which also run laboratory services, staff, M&E systems and procurement. Site investigator: Jonathan Euvrard

Kheth’Impilo AIDS Free Living is a nonprofit organization that supports the Government Departments of Health with public health systems innovations, technical assistance, service delivery and research in five sub-Saharan African countries. Kheth’Impilo currently contributes data to IeDEA-SA from 14 public health facilities in Umgungundlovu district of KwaZulu-Natal province in South Africa. This district has very high HIV prevalence (antenatal HIV prevalence of 42.5%), and approximately 120,000 patients are currently receiving antiretroviral treatment at these facilities.

Lighthouse Trust, a Public Trust and WHO-recognized Center of Excellence for integrated HIV prevention, treatment, care and support in Malawi, works in close collaboration with the Ministry of Health to operate two large integrated HIV testing, treatment and care clinics in Lilongwe, Malawi: one on the campus of Kamuzu Central Hospital and another, The Martin Preuss Center at Bwaila District Hospital, both in the Malawi capital, Lilongwe. Site investigator: Sam Phiri

Newlands Clinic runs an HIV treatment program in Harare, Zimbabwe -SA. Currently the clinic provides comprehensive care to over 5000 HIV infected patients. It is operated as a model private-public partnership with the Zimbabwe Ministry of Health and Child Care and Swiss Aids Care International. Site investigator: Cleophas Chimbetete

RMMCH is the only hospital providing care specifically for women and children in Gauteng Province, and runs the second largest ARV clinic for the treatment of children infected with HIV in Gauteng province. The hospital also boasts one of the leading PMTCT programs, as well as a research unit conducting clinical and HIV-related trials with international and local collaboration. Site investigator: Karl Technau.

The Red Cross War Memorial Children’s Hospital project is located within a tertiary referral hospital in Cape Town, South Africa. It is one of two tertiary referral centres in the Western Cape province, providing advanced care to sick children aged less than 15 years. Site investigator: Brian Eley

SolidarMed Lesotho is active in the rural districts of Butha Buthe and Thaba Tseka. The SMART project aims to improve access to quality HIV and chronic disease services for the population of these districts. At district and national level, a solid collaboration has been established with the Ministry of Health, the District Health Management Teams and other stakeholders. Site investigator: Josephine Muhairwe.

Solidarmed is active in the rural districts of Ancuabe and Chiure, which are situated in the Northern Province of Cabo Delgado, Mozambique. The SMART project aims to improve access to quality HIV and chronic disease services in the District. Recent achievements include the progressive decentralization of HIV services within the district by steadily increasing number of health centres offering HIV testing, counselling, and PMTCT services as well as ART. Site investigator: Anne Jores

The SMART project is active in the rural districts of Bikita and Zaka, which are situated in the province of Masvingo in Zimbabwe. The project aims to improve access to quality HIV and TB services for the population of the two districts. At district, provincial and national levels, a solid collaboration has been established with the Ministry of Health and the project works under the leadership of the Provincial Medical Director’s office.
Site investigator: Kamelia Kamenova3

The Health Economics and Epidemiology Research Office (HE2RO) of the Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa, is a research unit founded in 2004 under the auspices of the Faculty of Health Sciences at the University of the Witwatersrand in Johannesburg. It is dedicated to understanding the economic and epidemiological consequences of the HIV/AIDS epidemic and the effectiveness, benefits, and costs of interventions. It undertakes applied economic and epidemiological analysis aimed at generating relevant, practical information for policy makers and program managers.
Site investigator: Matthew Fox

Tygerberg Academic Hospital is one of two tertiary care facilities situated in Cape Town, serving the population of the Western Cape Province. TBH provides tertiary healthcare to half of the Western Cape and secondary level healthcare to the area of the Cape Town metropole surrounding the hospital. The ARV Clinic is responsible for the provision of ART in adults and children living in the vicinity of the hospital as well as managing complicated referrals. The family clinic was established in 1997 as a service for children and adults infected with HIV and funded from external sources. Site investigator: Hans Prozesky