Mark the date: November 1, 2021, is the general abstract and scholarship submission deadline for the 29th Conference on Retroviruses and Opportunistic Infections (CROI). CROI 2022 will be held on February 13 to 16, 2022, and is currently planned as a hybrid conference to include both virtual and in-person participation. The in-person component, hosted in Denver, Colorado, USA, will feature additional sessions and networking opportunities for those attending live. The CROI Scientific Program Committee will monitor the COVID-19 pandemic carefully in terms of changes in the safety and practicality of hosting an in-person component.