Mary-Ann has been co-Principal Investigator of IeDEA-SA since 2011. Her PhD thesis was entitled ‘Outcomes and effectiveness of antiretroviral therapy for HIV-infected children in South African treatment cohorts’. The thesis reviewed the outcomes of published studies of pediatric ART cohorts in Africa, described outcomes for children receiving ART in South Africa and examined determinants of mortality and generalizability across Southern Africa. Temporal trends in characteristics at ART were also examined. The measurement of treatment success in resource-limited settings was reviewed by examining virological failure and assessing the diagnostic accuracy of immunological criteria for identifying virological failure. The results chapters were presented in the form of published/submitted papers based on data from IeDEA-SA [1, 2, 3, 4, 5, 6, 7] . The thesis concluded that access to ART for children had increased, with good outcomes. HIV cohort research is important in evaluating the safety and effectiveness of different models of care, treatment and monitoring strategies.