Journal Articles Published In 2023

2775998 TCMBXKKM 2023 1 padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe 50 date desc year 3983 https://www.iedea-sa.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229LM6AC8B%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJent%2C%20Philipp%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBittel%2C%20Pascal%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFurrer%2C%20Lavinia%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Air%20cleaners%20and%20respiratory%20infections%20in%20schools%3A%20A%20modeling%20study%20using%20epidemiological%2C%20environmental%2C%20and%20molecular%20data.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.12.29.23300635.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.12.29.23300635%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.12.29.23300635%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Air%20cleaners%20and%20respiratory%20infections%20in%20schools%3A%20A%20modeling%20study%20using%20epidemiological%2C%20environmental%2C%20and%20molecular%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Jent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Bittel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavinia%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Bertschinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernest%22%2C%22lastName%22%3A%22Weingartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tina%22%2C%22lastName%22%3A%22Hascher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Using%20a%20multiple-measurement%20approach%2C%20we%20examined%20the%20real-world%20effectiveness%20of%20portable%20HEPA-air%20filtration%20devices%20%28air%20cleaners%29%20in%20a%20school%20setting.%5CnMETHODS%3A%20We%20collected%20environmental%20%28CO2%2C%20particle%20concentrations%29%2C%20epidemiological%20%28absences%20related%20to%20respiratory%20infections%29%2C%20audio%20%28coughing%29%2C%20and%20molecular%20data%20%28bioaerosol%20and%20saliva%20samples%29%20over%20seven%20weeks%20during%20winter%202022%5C%2F2023%20in%20two%20Swiss%20secondary%20school%20classes.%20Using%20a%20cross-over%20study%20design%2C%20we%20compared%20particle%20concentrations%2C%20coughing%2C%20and%20the%20risk%20of%20infection%20with%20vs%20without%20air%20cleaners.%5CnRESULTS%3A%20All%2038%20students%20%28age%2013-15%20years%29%20participated.%20With%20air%20cleaners%2C%20mean%20particle%20concentration%20decreased%20by%2077%25%20%2895%25%20credible%20interval%2063%25-86%25%29.%20There%20were%20no%20differences%20in%20CO2%20levels.%20Absences%20related%20to%20respiratory%20infections%20were%2022%20without%20vs%2013%20with%20air%20cleaners.%20Bayesian%20modeling%20suggested%20a%20reduced%20risk%20of%20infection%2C%20with%20a%20posterior%20probability%20of%2091%25%20and%20a%20relative%20risk%20of%200.73%20%2895%25%20credible%20interval%200.44-1.18%29.%20Coughing%20also%20tended%20to%20be%20less%20frequent%20%28posterior%20probability%2093%25%29.%20Molecular%20analysis%20detected%20mainly%20non-SARS-CoV-2%20viruses%20in%20saliva%20%2850%5C%2F448%20positive%29%2C%20but%20not%20in%20bioaerosols%20%282%5C%2F105%20positive%29%20or%20HEPA-filters%20%284%5C%2F160%29.%20The%20detection%20rate%20was%20similar%20with%20vs%20without%20air%20cleaners.%20Spatiotemporal%20analysis%20of%20positive%20saliva%20samples%20identified%20several%20likely%20transmissions.%5CnCONCLUSIONS%3A%20Air%20cleaners%20improved%20air%20quality%2C%20showed%20a%20potential%20benefit%20in%20reducing%20respiratory%20infections%2C%20and%20were%20associated%20with%20less%20coughing.%20Airborne%20detection%20of%20non-SARS-CoV-2%20viruses%20was%20rare%2C%20suggesting%20that%20these%20viruses%20may%20be%20more%20difficult%20to%20detect%20in%20the%20air.%20Future%20studies%20should%20examine%20the%20importance%20of%20close%20contact%20and%20long-range%20transmission%2C%20and%20the%20cost-effectiveness%20of%20using%20air%20cleaners.%22%2C%22date%22%3A%222023-12-30%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.12.29.23300635%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A50%3A02Z%22%7D%7D%2C%7B%22key%22%3A%222HTNPKKX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Trickey%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-19%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTrickey%2C%20Adam%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJohnson%2C%20Leigh%20F.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFung%2C%20Fai%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBonifacio%2C%20Rogerio%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIwuji%2C%20Collins%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Associations%20of%20inter-annual%20rainfall%20decreases%20with%20subsequent%20HIV%20outcomes%20for%20persons%20with%20HIV%20on%20antiretroviral%20therapy%20in%20Southern%20Africa%3A%20a%20collaborative%20analysis%20of%20cohort%20studies.%20%26lt%3Bi%26gt%3BBMC%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20889.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-023-08902-9%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12879-023-08902-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20of%20inter-annual%20rainfall%20decreases%20with%20subsequent%20HIV%20outcomes%20for%20persons%20with%20HIV%20on%20antiretroviral%20therapy%20in%20Southern%20Africa%3A%20a%20collaborative%20analysis%20of%20cohort%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Trickey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fai%22%2C%22lastName%22%3A%22Fung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogerio%22%2C%22lastName%22%3A%22Bonifacio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Collins%22%2C%22lastName%22%3A%22Iwuji%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Biraro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Chirimuta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20P.%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22Von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joe%22%2C%22lastName%22%3A%22Gumulira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Howard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%22%2C%22lastName%22%3A%22Jennings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agnes%22%2C%22lastName%22%3A%22Kiragga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Tanser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thorsten%22%2C%22lastName%22%3A%22Wagener%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Vickerman%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Periods%20of%20droughts%20can%20lead%20to%20decreased%20food%20security%2C%20and%20altered%20behaviours%2C%20potentially%20affecting%20outcomes%20on%20antiretroviral%20therapy%20%28ART%29%20among%20persons%20with%20HIV%20%28PWH%29.%20We%20investigated%20whether%20decreased%20rainfall%20is%20associated%20with%20adverse%20outcomes%20among%20PWH%20on%20ART%20in%20Southern%20Africa.%5CnMETHODS%3A%20Data%20were%20combined%20from%2011%20clinical%20cohorts%20of%20PWH%20in%20Lesotho%2C%20Malawi%2C%20Mozambique%2C%20South%20Africa%2C%20Zambia%2C%20and%20Zimbabwe%2C%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Southern%20Africa%20%28IeDEA-SA%29%20collaboration.%20Adult%20PWH%20who%20had%20started%20ART%20prior%20to%2001%5C%2F06%5C%2F2016%20and%20were%20in%20follow-up%20in%20the%20year%20prior%20to%2001%5C%2F06%5C%2F2016%20were%20included.%20Two-year%20rainfall%20from%20June%202014%20to%20May%202016%20at%20the%20location%20of%20each%20HIV%20centre%20was%20summed%20and%20ranked%20against%20historical%202-year%20rainfall%20amounts%20%281981-2016%29%20to%20give%20an%20empirical%20relative%20percentile%20rainfall%20estimate.%20The%20IeDEA-SA%20and%20rainfall%20data%20were%20combined%20using%20each%20HIV%20centre%26%23039%3Bs%20latitude%5C%2Flongitude.%20In%20individual-level%20analyses%2C%20multivariable%20Cox%20or%20generalized%20estimating%20equation%20regression%20models%20%28GEEs%29%20assessed%20associations%20between%20decreased%20rainfall%20versus%20historical%20levels%20and%20four%20separate%20outcomes%20%28mortality%2C%20CD4%20counts%5Cu2009%26lt%3B%5Cu2009200%20cells%5C%2Fmm3%2C%20viral%20loads%5Cu2009%26gt%3B%5Cu2009400%20copies%5C%2FmL%2C%20and%5Cu2009%26gt%3B%5Cu200912-month%20gaps%20in%20follow-up%29%20in%20the%20two%20years%20following%20the%20rainfall%20period.%20GEEs%20were%20used%20to%20investigate%20the%20association%20between%20relative%20rainfall%20and%20monthly%20numbers%20of%20unique%20visitors%20per%20HIV%20centre.%5CnRESULTS%3A%20Among%20270%2C708%20PWH%20across%20386%20HIV%20centres%20%2867%25%20female%2C%20median%20age%2039%20%5BIQR%3A%2032-46%5D%29%2C%20lower%20rainfall%20than%20usual%20was%20associated%20with%20higher%20mortality%20%28adjusted%20Hazard%20Ratio%3A%201.18%20%5B95%25CI%3A%201.07-1.32%5D%20per%2010%20percentile%20rainfall%20rank%20decrease%29%20and%20unsuppressed%20viral%20loads%20%28adjusted%20Odds%20Ratio%3A%201.05%20%5B1.01-1.09%5D%29.%20Levels%20of%20rainfall%20were%20not%20strongly%20associated%20with%20CD4%20counts%5Cu2009%26lt%3B%5Cu2009200%20cell%5C%2Fmm3%20or%5Cu2009%26gt%3B%5Cu200912-month%20gaps%20in%20care.%20HIV%20centres%20in%20areas%20with%20less%20rainfall%20than%20usual%20had%20lower%20numbers%20of%20PWH%20visiting%20them%20%28adjusted%20Rate%20Ratio%3A%200.80%20%5B0.66-0.98%5D%20per%2010%20percentile%20rainfall%20rank%20decrease%29.%5CnCONCLUSIONS%3A%20Decreased%20rainfall%20could%20negatively%20impact%20on%20HIV%20treatment%20behaviours%20and%20outcomes.%20Further%20research%20is%20needed%20to%20explore%20the%20reasons%20for%20these%20effects.%20Interventions%20to%20mitigate%20the%20health%20impact%20of%20severe%20weather%20events%20are%20required.%22%2C%22date%22%3A%222023-12-19%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12879-023-08902-9%22%2C%22ISSN%22%3A%221471-2334%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A20%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22I5QF6ZNX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Skrivankova%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-16%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSkrivankova%2C%20Veronika%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20Morna%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBallif%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDupont%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Authorship%20inequalities%20in%20global%20health%20research%3A%20the%20IeDEA%20Southern%20Africa%20collaboration.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B8%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%20e013316.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2023-013316%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2023-013316%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Authorship%20inequalities%20in%20global%20health%20research%3A%20the%20IeDEA%20Southern%20Africa%20collaboration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20W.%22%2C%22lastName%22%3A%22Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Dupont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantinos%22%2C%22lastName%22%3A%22Seintaridis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thokozani%22%2C%22lastName%22%3A%22Kalua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20conducts%20research%20in%20several%20regions%2C%20including%20in%20Southern%20Africa.%20We%20assessed%20authorship%20inequalities%20for%20the%20Southern%20African%20region%2C%20which%20is%20led%20by%20South%20African%20and%20Swiss%20investigators.%5CnMETHODS%3A%20We%20analysed%20authorships%20of%20publications%20from%202007%20to%202020%20by%20gender%2C%20country%20income%20group%2C%20time%20and%20citation%20impact.%20We%20used%202020%20World%20Bank%20categories%20to%20define%20income%20groups%20and%20the%20relative%20citation%20ratio%20%28RCR%29%20to%20assess%20citation%20impact.%20Authorship%20parasitism%20was%20defined%20as%20articles%20without%20authors%20from%20the%20countries%20where%20the%20study%20was%20conducted.%20A%20regression%20model%20examined%20the%20probability%20of%20different%20authorship%20positions.%5CnRESULTS%3A%20We%20included%20313%20articles.%20Of%20the%201064%20contributing%20authors%2C%20547%20%2851.4%25%29%20were%20women%2C%20and%20223%20%2821.0%25%29%20were%20from%2032%20low-income%5C%2Flower%20middle-income%20countries%20%28LLMICs%29%2C%20269%20%2825.3%25%29%20were%20from%2013%20upper%20middle-income%20countries%20and%20572%20%2853.8%25%29%20were%20from%2025%20high-income%20countries%20%28HICs%29.%20Most%20articles%20%28150%5C%2F157%2C%2095.5%25%29%20reporting%20data%20from%20Southern%20Africa%20included%20authors%20from%20all%20participating%20countries.%20Women%20were%20more%20likely%20to%20be%20the%20first%20author%20than%20men%20%28OR%201.74%3B%2095%25%5Cu2009CI%201.06%20to%202.83%29%20but%20less%20likely%20to%20be%20last%20authors%20%28OR%200.63%3B%2095%25%5Cu2009CI%200.40%20to%200.99%29.%20Compared%20with%20HIC%2C%20LLMIC%20authors%20were%20less%20likely%20to%20publish%20as%20first%20%28OR%200.21%3B%2095%25%5Cu2009CI%200.11%20to%200.41%29%20or%20last%20author%20%28OR%200.20%3B%2095%25%5Cu2009CI%200.09%20to%200.42%29.%20The%20proportion%20of%20women%20and%20LLMIC%20first%20and%20last%20authors%20increased%20over%20time.%20The%20RCR%20tended%20to%20be%20higher%2C%20indicating%20greater%20impact%2C%20if%20first%20or%20last%20authors%20were%20from%20HIC%20%28p%3D0.06%29.%5CnCONCLUSIONS%3A%20This%20analysis%20of%20a%20global%20health%20collaboration%20co-led%20by%20South%20African%20and%20Swiss%20investigators%20showed%20little%20evidence%20of%20authorship%20parasitism.%20There%20were%20stark%20inequalities%20in%20authorship%20position%2C%20with%20women%20occupying%20more%20first%20and%20men%20more%20last%20author%20positions%20and%20researchers%20from%20LLMIC%20being%20%26%23039%3Bstuck%20in%20the%20middle%26%23039%3B%20on%20the%20byline.%20Global%20health%20research%20collaborations%20should%20monitor%2C%20analyse%20and%20address%20authorship%20inequalities.%22%2C%22date%22%3A%222023-12-16%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2023-013316%22%2C%22ISSN%22%3A%222059-7908%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A22%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22MGI477IL%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWettstein%2C%20Anja%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMesa-Vieira%2C%20Cristina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Life%20years%20lost%20associated%20with%20mental%20illness%3A%20A%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%20%26lt%3Bi%26gt%3BJournal%20of%20Affective%20Disorders%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B340%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20204%26%23x2013%3B212.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.08.013%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.08.013%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life%20years%20lost%20associated%20with%20mental%20illness%3A%20A%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mesa-Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chanwyn%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20People%20with%20mental%20illness%20have%20a%20reduced%20life%20expectancy%2C%20but%20the%20extent%20of%20the%20mortality%20gap%20and%20the%20contribution%20of%20natural%20and%20unnatural%20causes%20to%20excess%20mortality%20among%20people%20with%20mental%20illness%20in%20South%20Africa%20are%20unknown.%5CnMETHODS%3A%20We%20analysed%20reimbursement%20claims%20from%20South%20African%20medical%20insurance%20scheme%20beneficiaries%20aged%2015-85%5Cu00a0years.%20We%20estimated%20excess%20life%20years%20lost%20%28LYL%29%20associated%20with%20organic%2C%20substance%20use%2C%20psychotic%2C%20mood%2C%20anxiety%2C%20eating%2C%20personality%2C%20developmental%20or%20any%20mental%20disorders.%5CnRESULTS%3A%20We%20followed%201%2C070%2C183%20beneficiaries%20for%20a%20median%20of%20three%20years%2C%20of%20whom%20282%2C926%20%2826.4%5Cu00a0%25%29%20received%20mental%20health%20diagnoses.%20Men%20with%20a%20mental%20health%20diagnosis%20lost%203.83%20life%20years%20%2895%5Cu00a0%25%20CI%203.58-4.10%29%20compared%20to%20men%20without.%20Women%20with%20a%20mental%20health%20diagnosis%20lost%202.19%20life%20years%20%281.97-2.41%29%20compared%20to%20women%20without.%20Excess%20mortality%20varied%20by%20sex%20and%20diagnosis%2C%20from%2011.50%20LYL%20%2895%5Cu00a0%25%20CI%209.79-13.07%29%20among%20men%20with%20alcohol%20use%20disorder%20to%200.87%20LYL%20%280.40-1.43%29%20among%20women%20with%20generalised%20anxiety%20disorder.%20Most%20LYL%20were%20attributable%20to%20natural%20causes%20%28men%3A%203.42%2C%20women%3A%201.94%29.%20A%20considerable%20number%20of%20LYL%20were%20attributable%20to%20unnatural%20causes%20among%20men%20with%20bipolar%20%281.52%29%20or%20substance%20use%20%282.45%29%20disorder.%5CnLIMITATIONS%3A%20Mental%20diagnoses%20are%20based%20on%20reimbursement%20claims.%5CnCONCLUSIONS%3A%20Premature%20mortality%20among%20South%20African%20individuals%20with%20mental%20disorders%20is%20high.%20Our%20findings%20support%20interventions%20for%20the%20prevention%2C%20early%20detection%2C%20and%20treatment%20of%20physical%20comorbidities%20in%20this%20population.%20Targeted%20programs%20for%20suicide%20prevention%20and%20substance%20use%20treatment%2C%20particularly%20among%20men%2C%20can%20help%20reduce%20excess%20mortality%20from%20unnatural%20causes.%22%2C%22date%22%3A%222023-11-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jad.2023.08.013%22%2C%22ISSN%22%3A%221573-2517%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A08%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22MYPZC62H%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Muula%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBosomprah%2C%20Samuel%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSinkala%2C%20Edford%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNsokolo%2C%20Bright%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusonda%2C%20Taonga%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Hepatitis%20B%20viral%20replication%20markers%20and%20hepatic%20fibrosis%20in%20untreated%20chronic%20hepatitis%20B%20virus%20infection%20with%20and%20without%20HIV%20coinfection%20in%20Zambia.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%2813%29%2C%20S.%202015%26%23x2013%3B2020.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003659%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003659%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hepatitis%20B%20viral%20replication%20markers%20and%20hepatic%20fibrosis%20in%20untreated%20chronic%20hepatitis%20B%20virus%20infection%20with%20and%20without%20HIV%20coinfection%20in%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%20K.%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edford%22%2C%22lastName%22%3A%22Sinkala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bright%22%2C%22lastName%22%3A%22Nsokolo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taonga%22%2C%22lastName%22%3A%22Musonda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kalongo%22%2C%22lastName%22%3A%22Hamusonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Debika%22%2C%22lastName%22%3A%22Bhattacharya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georg%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raymond%20T.%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lloyd%20B.%22%2C%22lastName%22%3A%22Mulenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Vinikoor%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20To%20inform%20novel%20therapies%2C%20a%20more%20nuanced%20understanding%20of%20HIV%26%23039%3Bs%20impact%20on%20hepatitis%20B%20virus%20%28HBV%29%20natural%20history%20is%20needed%2C%20particularly%20in%20high%20burden%20countries.%5CnMETHODS%3A%20In%20Lusaka%2C%20Zambia%2C%20we%20compared%20prospectively%20recruited%20adults%20%2818%2B%20years%29%20with%20chronic%20HBV%20infection%2C%20with%20and%20without%20HIV.%20We%20excluded%20those%20with%20prior%20antiviral%20treatment%20experience%20or%20HBV%20diagnosis%20due%20to%20clinical%20suspicion%20%28rather%20than%20routine%20testing%29.%20We%20assessed%20HBV%20DNA%20levels%2C%20hepatitis%20B%20e%20antigen%20%28HBeAg%29%2C%20CD4%20%2B%20%28if%20HIV%20coinfection%29%2C%20and%20liver%20disease%20%28transient%20elastography%2C%20serum%20alanine%20aminotransferase%29.%20In%20multivariable%20analyses%2C%20we%20evaluated%20the%20association%20of%20HIV%20overall%20and%20by%20level%20of%20CD4%20%2B%20count%20on%20these%20markers.%5CnRESULTS%3A%20Among%20713%20adults%20analyzed%2C%20median%20age%20was%2033%5Cu200ayears%2C%2063%25%20were%20male%2C%20and%20433%20had%20HBV%5C%2FHIV%20coinfection.%20Median%20CD4%20%2B%20count%20was%20200%5Cu200acells%5C%2F%5Cu03bcl.%20HBV%20DNA%20was%20greater%20than%202000%5Cu200aIU%5C%2Fml%20for%20311%20%2851.0%25%29%20and%20227%20%2832.5%25%29%20were%20HBeAg-positive.%2015.5%25%20had%20advanced%20fibrosis%20or%20cirrhosis.%20HIV%20coinfection%20was%20associated%20with%20five-fold%20increased%20HBV%20DNA%20levels%20%5Badjusted%20geometric%20mean%20ratio%2C%205.78%3B%2095%25%20confidence%20interval%20%28CI%29%2C%202.29-14.62%5D%20and%20two%20times%20the%20odds%20of%20HBeAg-positivity%20%28adjusted%20odds%20ratio%2C%202.54%3B%2095%25%20CI%2C%201.59-4.08%29.%20These%20associations%20were%20significant%20only%20at%20CD4%20%2B%20counts%20100-350%20and%20%26lt%3B100%5Cu200acells%5C%2F%5Cu03bcl.%20HIV%20was%20not%20associated%20with%20markers%20of%20fibrosis%20or%20ALT.%5CnDISCUSSION%3A%20HIV%26%23039%3Bs%20impact%20on%20HBV%20natural%20history%20likely%20depends%20on%20the%20degree%20and%20duration%20of%20immune%20suppression.%20There%20is%20strong%20rationale%20to%20monitor%20HBV%20DNA%20in%20people%20with%20HBV%5C%2FHIV%20coinfection%20and%20immune%20suppression.%20A%20better%20understanding%20is%20needed%20of%20mechanisms%20of%20increased%20liver-related%20mortality%20in%20people%20with%20HBV%5C%2FHIV%20coinfection.%22%2C%22date%22%3A%222023-11-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003659%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T09%3A56%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22RSD8GVHK%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loosli%20et%20al.%22%2C%22parsedDate%22%3A%222023-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOkhai%2C%20Hajra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKusejko%2C%20Katharina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20HIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20a%20collaborative%20cohort%20analysis.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20HIV%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%2811%29%2C%20S.%20e733%26%23x2013%3Be741.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2823%2900228-X%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2352-3018%2823%2900228-X%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22HIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20antiretroviral%20therapy%3A%20a%20collaborative%20cohort%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajra%22%2C%22lastName%22%3A%22Okhai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kusejko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Mouton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pantxika%22%2C%22lastName%22%3A%22Bellecave%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ard%22%2C%22lastName%22%3A%22van%20Sighem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Stecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonella%22%2C%22lastName%22%3A%22d%27Arminio%20Monforte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20John%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%20A.%22%2C%22lastName%22%3A%22Sabin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20widespread%20use%20of%20the%20integrase%20strand%20transfer%20inhibitor%20%28INSTI%29%20dolutegravir%20in%20first-line%20and%20second-line%20antiretroviral%20therapy%20%28ART%29%20might%20facilitate%20emerging%20resistance.%20The%20DTG%20RESIST%20study%20combined%20data%20from%20HIV%20cohorts%20to%20examine%20patterns%20of%20drug%20resistance%20mutations%20%28DRMs%29%20and%20identify%20risk%20factors%20for%20dolutegravir%20resistance.%5CnMETHODS%3A%20We%20included%20cohorts%20with%20INSTI%20resistance%20data%20from%20two%20collaborations%20%28ART%20Cohort%20Collaboration%2C%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20in%20Southern%20Africa%29%2C%20and%20the%20UK%20Collaborative%20HIV%20Cohort.%20Eight%20cohorts%20from%20Canada%2C%20France%2C%20Germany%2C%20Italy%2C%20the%20Netherlands%2C%20Switzerland%2C%20South%20Africa%2C%20and%20the%20UK%20contributed%20data%20on%20individuals%20who%20were%20viraemic%20on%20dolutegravir-based%20ART%20and%20underwent%20genotypic%20resistance%20testing.%20Individuals%20with%20unknown%20dolutegravir%20initiation%20date%20were%20excluded.%20Resistance%20levels%20were%20categorised%20using%20the%20Stanford%20algorithm.%20We%20identified%20risk%20factors%20for%20resistance%20using%20mixed-effects%20ordinal%20logistic%20regression%20models.%5CnFINDINGS%3A%20We%20included%20599%20people%20with%20genotypic%20resistance%20testing%20on%20dolutegravir-based%20ART%20between%20May%2022%2C%202013%2C%20and%20Dec%2020%2C%202021.%20Most%20had%20HIV-1%20subtype%20B%20%28n%3D351%2C%2059%25%29%2C%20a%20third%20had%20been%20exposed%20to%20first-generation%20INSTIs%20%28n%3D193%2C%2032%25%29%2C%2070%20%2812%25%29%20were%20on%20dolutegravir%20dual%20therapy%2C%20and%2018%20%283%25%29%20were%20on%20dolutegravir%20monotherapy.%20INSTI%20DRMs%20were%20detected%20in%2086%20%2814%25%29%20individuals%3B%2020%20%283%25%29%20had%20more%20than%20one%20mutation.%20Most%20%28n%3D563%2C%2094%25%29%20were%20susceptible%20to%20dolutegravir%2C%20seven%20%281%25%29%20had%20potential%20low%2C%20six%20%281%25%29%20low%2C%2017%20%283%25%29%20intermediate%2C%20and%20six%20%281%25%29%20high-level%20dolutegravir%20resistance.%20The%20risk%20of%20dolutegravir%20resistance%20was%20higher%20on%20dolutegravir%20monotherapy%20%28adjusted%20odds%20ratio%20%5BaOR%5D%2034%5Cu00b71%2C%2095%25%20CI%209%5Cu00b793-117%29%20and%20dolutegravir%20plus%20lamivudine%20dual%20therapy%20%28aOR%209%5Cu00b721%2C%202%5Cu00b720-38%5Cu00b76%29%20compared%20with%20combination%20ART%2C%20and%20in%20the%20presence%20of%20potential%20low%20or%20low%20%28aOR%205%5Cu00b723%2C%201%5Cu00b732-20%5Cu00b77%29%20or%20intermediate%20or%20high-level%20%28aOR%2013%5Cu00b74%2C%204%5Cu00b755-39%5Cu00b77%29%20nucleoside%20reverse%20transcriptase%20inhibitor%20%28NRTI%29%20resistance.%5CnINTERPRETATION%3A%20Among%20people%20with%20viraemia%20on%20dolutegravir-based%20ART%2C%20INSTI%20DRMs%20and%20dolutegravir%20resistance%20were%20rare.%20NRTI%20resistance%20substantially%20increased%20the%20risk%20of%20dolutegravir%20resistance%2C%20which%20is%20of%20concern%2C%20notably%20in%20resource-limited%20settings.%20Monitoring%20is%20important%20to%20prevent%20resistance%20at%20the%20individual%20and%20population%20level%20and%20ensure%20the%20long-term%20sustainability%20of%20ART.%5CnFUNDING%3A%20US%20National%20Institutes%20of%20Health%2C%20Swiss%20National%20Science%20Foundation.%22%2C%22date%22%3A%222023-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS2352-3018%2823%2900228-X%22%2C%22ISSN%22%3A%222352-3018%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-07-26T10%3A08%3A18Z%22%7D%7D%2C%7B%22key%22%3A%228JN7GFW9%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metekoua%20et%20al.%22%2C%22parsedDate%22%3A%222023-10-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMetekoua%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Decreasing%20incidence%20of%20conjunctival%20squamous%20cell%20carcinoma%20in%20people%20with%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20National%20Cancer%20Institute%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B115%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%201213%26%23x2013%3B1219.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjnci%5C%2Fdjad119%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fjnci%5C%2Fdjad119%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Decreasing%20incidence%20of%20conjunctival%20squamous%20cell%20carcinoma%20in%20people%20with%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Metekoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20main%20risk%20factors%20for%20squamous%20cell%20carcinoma%20of%20the%20conjunctiva%20%28SCCC%29%20are%20immunodeficiency%20and%20exposure%20to%20ultraviolet%20radiation.%20Little%20is%20known%20about%20SCCC%20epidemiology%20among%20people%20with%20HIV%20%28PWH%29%20in%20South%20Africa.%5CnMETHODS%3A%20We%20used%20data%20from%20the%20South%20African%20HIV%20Cancer%20Match%20study%2C%20a%20nation-wide%20cohort%20of%20PWH%20in%20South%20Africa%2C%20created%20through%20a%20privacy-preserving%20probabilistic%20record%20linkage%20of%20HIV-related%20laboratory%20records%20from%20the%20National%20Health%20Laboratory%20Service%20and%20cancer%20records%20from%20the%20National%20Cancer%20Registry%20from%202004%20to%202014.%20We%20calculated%20crude%20incidence%20rates%2C%20analyzed%20trends%20using%20joinpoint%20models%2C%20and%20estimated%20hazard%20ratios%20for%20different%20risk%20factors%20using%20Royston-Parmar%20flexible%20parametric%20survival%20models.%5CnRESULTS%3A%20Among%205%5Cu200a247%5Cu200a968%20PWH%2C%201059%20cases%20of%20incident%20SCCC%20were%20diagnosed%2C%20for%20a%20crude%20overall%20SCCC%20incidence%20rate%20of%206.8%20per%20100%5Cu200a000%20person-years.%20The%20SCCC%20incidence%20rate%20decreased%20between%202004%20and%202014%2C%20with%20an%20annual%20percentage%20change%20of%20%5Cu201210.9%25%20%2895%25%20confidence%20interval%3A%20%5Cu201213.3%20to%20%5Cu20128.3%29.%20PWH%20residing%20within%20latitudes%2030%5Cu00b0S%20to%2034%5Cu00b0S%20had%20a%2049%25%20lower%20SCCC%20risk%20than%20those%20residing%20at%20less%20than%2025%5Cu00b0S%20latitude%20%28adjusted%20hazard%20ratio%5Cu2009%3D%5Cu20090.67%3B%2095%25%20confidence%20interval%3A%200.55%20to%200.82%29.%20Other%20risk%20factors%20for%20SCCC%20were%20lower%20CD4%20counts%20and%20middle%20age.%20There%20was%20no%20evidence%20for%20an%20association%20of%20sex%20or%20settlement%20type%20with%20SCCC%20risk.%5CnCONCLUSIONS%3A%20An%20increased%20risk%20of%20developing%20SCCC%20was%20associated%20with%20lower%20CD4%20counts%20and%20residence%20closer%20to%20the%20equator%2C%20indicative%20of%20higher%20ultraviolet%20radiation%20exposure.%20Clinicians%20and%20PWH%20should%20be%20educated%20on%20known%20SCCC%20preventive%20measures%2C%20such%20as%20maintaining%20high%20CD4%20counts%20and%20protection%20from%20ultraviolet%20radiation%20through%20sunglasses%20and%20sunhats%20when%20outdoors.%22%2C%22date%22%3A%222023-10-09%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fjnci%5C%2Fdjad119%22%2C%22ISSN%22%3A%221460-2105%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T10%3A00%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22TUIRIF5D%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Beer%20et%20al.%22%2C%22parsedDate%22%3A%222023-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSlogrove%2C%20Amy%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Hayley%20E.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Change%20in%20HIV-related%20characteristics%20of%20children%20hospitalised%20with%20infectious%20diseases%20in%20Western%20Cape%2C%20South%20Africa%2C%202008-2021%3A%20a%20time%20trend%20analysis.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%20Suppl%204%26lt%3B%5C%2Fi%26gt%3B%20%28Suppl%204%29%2C%20S.%20e26151.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26151%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26151%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Change%20in%20HIV-related%20characteristics%20of%20children%20hospitalised%20with%20infectious%20diseases%20in%20Western%20Cape%2C%20South%20Africa%2C%202008-2021%3A%20a%20time%20trend%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%20T.%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hayley%20E.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20With%20the%20scaling%20up%20of%20vertical%20HIV%20transmission%20prevention%20programmes%2C%20the%20HIV-related%20population%20profile%20of%20children%20in%20South%20Africa%20has%20shifted.%20We%20described%20temporal%20changes%20in%20HIV-related%20characteristics%20of%20children%2C%20aged%20%5Cu22643%20years%20%28up%20to%20the%20third%20birthday%29%2C%20with%20infectious%20disease%20hospitalisations%20across%20the%20Western%20Cape%20province.%5CnMETHODS%3A%20We%20used%20routinely%20collected%20electronic%20data%20to%20identify%20children%20born%20in%20the%20Western%20Cape%20with%20infectious%20disease%20hospital%20records%20for%20lower%20respiratory%20tract%20infections%2C%20diarrhoea%2C%20meningitis%20and%20tuberculous%20meningitis%2C%20from%202008%20to%202021.%20Linked%20maternal%20and%20child%20unique%20identifiers%20were%20used%20to%20extract%20pregnancy%2C%20HIV-related%2C%20laboratory%2C%20pharmacy%20and%20hospitalisation%20data.%20We%20described%20temporal%20changes%20in%20child%20HIV%20exposure%20and%20acquisition%20status%2C%20timing%20of%20maternal%20HIV%20diagnosis%20and%20antiretroviral%20therapy%20%28ART%29%20start%2C%20infant%20exposure%20to%20maternal%20ART%20and%20timing%20thereof%2C%20and%20maternal%20CD4%20and%20HIV%20viral%20load%20closest%20to%20delivery.%20We%20used%20logistic%20and%20multinomial%20regression%20to%20assess%20changes%20in%20characteristics%20between%20the%20Pre-Option%20B%2B%20%282008-2013%29%2C%20Option%20B%2B%20%282013-2016%29%20and%20Universal%20ART%20periods%20%282016-2021%29.%5CnRESULTS%3A%20Among%2052%2C811%20children%20aged%20%5Cu22643%20years%20with%20hospitalisations%2C%20the%20proportion%20living%20with%20HIV%20dreased%20from%207.0%25%20%282008%29%20to%201.1%25%20%282021%29%2C%20while%20those%20exposed%20to%20HIV%20and%20uninfected%20increased%20from%2014.0%25%20%282008%29%20to%2016.1%25%20%282021%29%20with%20a%20peak%20of%2018.3%25%20in%202017.%20Among%20mothers%20with%20HIV%20%28n%20%3D%209873%29%2C%20the%20proportion%20diagnosed%20with%20HIV%20and%20starting%20ART%20before%20pregnancy%20increased%20from%2020.2%25%20to%2069.2%25%20and%205.8%25%20to%2059.0%25%2C%20respectively%2C%20between%202008%20and%202021.%20Children%20hospitalised%20during%20the%20Universal%20ART%20period%20had%20eight%20times%20higher%20odds%20%28Odds%20Ratio%3A%208.41%3B%2095%25%20CI%3A%207.36-9.61%29%20of%20exposure%20to%20maternal%20ART%20versus%20children%20admitted%20Pre-Option%20B%2B.%20Among%20mothers%20of%20children%20exposed%20to%20HIV%20and%20uninfected%20with%20CD4%20records%20%28n%20%3D%207523%29%2C%20the%20proportion%20with%20CD4%20%26lt%3B350%20cells%5C%2F%5Cu03bcl%20decreased%20from%2090.6%25%20%282008%29%20to%2027.8%25%20%282021%29.%5CnCONCLUSIONS%3A%20In%20recent%20years%2C%20among%20children%20hospitalised%20with%20infectious%20diseases%2C%20there%20were%20fewer%20children%20with%20perinatally%20acquired%20HIV%2C%20while%20an%20increased%20proportion%20of%20those%20without%20HIV%20acquisition%20are%20exposed%20to%20maternal%20HIV%20and%20ART.%20There%20is%20a%20need%20to%20look%20beyond%20paediatric%20HIV%20prevalence%20and%20consider%20child%20exposure%20to%20HIV%20and%20ART%20among%20children%20without%20HIV%2C%20when%20assessing%20the%20HIV%20epidemic%26%23039%3Bs%20impact%20on%20child%20health%20services.%22%2C%22date%22%3A%222023-10%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26151%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T09%3A56%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22L9URNVGG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Slogrove%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSlogrove%2C%20Amy%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBovu%2C%20Andisiwe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWilliams%2C%20Paige%20L.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Maternal%20and%20birth%20outcomes%20in%20pregnant%20people%20with%20and%20without%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20population-based%20cohort%20study.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003728%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003728%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Maternal%20and%20birth%20outcomes%20in%20pregnant%20people%20with%20and%20without%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20population-based%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andisiwe%22%2C%22lastName%22%3A%22Bovu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paige%20L.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ushma%22%2C%22lastName%22%3A%22Mehta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Theron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%20J.%22%2C%22lastName%22%3A%22Abrams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20F.%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20We%20evaluated%20associations%20of%20HIV%20and%20antiretroviral%20therapy%20%28ART%29%20with%20birth%20and%20maternal%20outcomes%20at%20a%20province-wide-level%20in%20the%20Western%20Cape%2C%20South%20Africa%2C%20in%20a%20recent%20cohort%20before%20dolutegravir-based%20first-line%20ART%20implementation.%5CnMETHODS%3A%20This%20retrospective%20cohort%20study%20included%20pregnant%20people%20delivering%20in%202018-2019%20with%20data%20in%20the%20Western%20Cape%20Provincial%20Health%20Data%20Centre%20which%20integrates%20individual-level%20data%20on%20all%20public%20sector%20patients%20from%20multiple%20electronic%20platforms%20using%20unique%20identifiers.%20Adverse%20birth%20outcomes%20%28stillbirth%2C%20low%20birth%20weight%20%28LBW%29%2C%20very%20LBW%20%28VLBW%29%29%20and%20maternal%20outcomes%20%28early%20and%20late%20pregnancy-related%20deaths%2C%20early%20and%20late%20hospitalizations%29%20were%20compared%20by%20HIV%5C%2FART%20status%20and%20adjusted%20prevalence%20ratios%20%28aPRs%29%20calculated%20using%20log-binomial%20regression.%5CnRESULTS%3A%20Overall%20171%2C960%20pregnant%20people%20and%20their%20singleton%20newborns%20were%20included%2C%2019%25%20%28N%5Cu200a%3D%5Cu200a32%2C015%29%20identified%20with%20HIV.%20Amongst%20pregnant%20people%20with%20HIV%20%28PPHIV%29%2C%2060%25%20%28N%5Cu200a%3D%5Cu200a19%2C157%29%20were%20on%20ART%20preconception%2C%2029%25%20%28N%5Cu200a%3D%5Cu200a9%2C276%29%20initiated%20ART%20during%20pregnancy%20and%2011%25%20%28N%5Cu200a%3D%5Cu200a3%2C582%29%20had%20no%20ART.%20Adjusted%20for%20maternal%20age%2C%20multiparity%2C%20hypertensive%20disorders%20and%20residential%20district%2C%20stillbirths%20were%20higher%20only%20for%20PPHIV%20not%20on%20ART%20%28aPR%201.31%20%5B95%25CI%201.04-1.66%5D%29%20compared%20to%20those%20without%20HIV.%20However%2C%20LBW%20and%20VLBW%20were%20higher%20among%20all%20PPHIV%2C%20with%20aPRs%20of%201.11-1.22%20for%20LBW%20and%201.14-1.54%20for%20VLBW.%20Pregnancy-initiated%20ART%20was%20associated%20with%20early%20pregnancy-related%20death%20%28aPR%203.21%3B%2095%25CI%201.55-6.65%29%2C%20and%20HIV%20with%20or%20without%20ART%20was%20associated%20with%20late%20pregnancy-related%20death%20%28aPRs%207.89-9.01%29.%5CnCONCLUSIONS%3A%20Even%20in%20the%20universal%20ART%20era%2C%20PPHIV%20experienced%20higher%20rates%20of%20LBW%20and%20VLBW%20newborns%2C%20and%20higher%20late%20pregnancy-related%20death%20regardless%20of%20ART%20status%20than%20pregnant%20people%20without%20HIV.%22%2C%22date%22%3A%222023-09-15%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003728%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A09%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22J88A92VI%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hansford%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHansford%2C%20Harrison%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCashin%2C%20Aidan%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Matthew%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSwanson%2C%20Sonja%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIslam%2C%20Nazrul%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Development%20of%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20guideline.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e074626.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-074626%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2023-074626%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20guideline%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harrison%20J.%22%2C%22lastName%22%3A%22Hansford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aidan%20G.%22%2C%22lastName%22%3A%22Cashin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20D.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%20A.%22%2C%22lastName%22%3A%22Swanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazrul%22%2C%22lastName%22%3A%22Islam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issa%20J.%22%2C%22lastName%22%3A%22Dahabreh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbra%20A.%22%2C%22lastName%22%3A%22Dickerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xavier%22%2C%22lastName%22%3A%22Garcia-Albeniz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20M.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Lodi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margarita%22%2C%22lastName%22%3A%22Moreno-Betancur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sallie-Anne%22%2C%22lastName%22%3A%22Pearson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Schneeweiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20K.%22%2C%22lastName%22%3A%22Sharp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20A.%22%2C%22lastName%22%3A%22Stuart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%20A.%22%2C%22lastName%22%3A%22Hernan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hopin%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20H.%22%2C%22lastName%22%3A%22McAuley%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Observational%20studies%20are%20increasingly%20used%20to%20inform%20health%20decision-making%20when%20randomised%20trials%20are%20not%20feasible%2C%20ethical%20or%20timely.%20The%20target%20trial%20approach%20provides%20a%20framework%20to%20help%20minimise%20common%20biases%20in%20observational%20studies%20that%20aim%20to%20estimate%20the%20causal%20effect%20of%20interventions.%20Incomplete%20reporting%20of%20studies%20using%20the%20target%20trial%20framework%20limits%20the%20ability%20for%20clinicians%2C%20researchers%2C%20patients%20and%20other%20decision-makers%20to%20appraise%2C%20synthesise%20and%20interpret%20findings%20to%20inform%20clinical%20and%20public%20health%20practice%20and%20policy.%20This%20paper%20describes%20the%20methods%20that%20we%20will%20use%20to%20develop%20the%20TrAnsparent%20ReportinG%20of%20observational%20studies%20Emulating%20a%20Target%20trial%20%28TARGET%29%20reporting%20guideline.%5CnMETHODS%5C%2FDESIGN%3A%20The%20TARGET%20reporting%20guideline%20will%20be%20developed%20in%20five%20stages%20following%20recommended%20guidance.%20The%20first%20stage%20will%20identify%20target%20trial%20reporting%20practices%20by%20systematically%20reviewing%20published%20studies%20that%20explicitly%20emulated%20a%20target%20trial.%20The%20second%20stage%20will%20identify%20and%20refine%20items%20to%20be%20considered%20for%20inclusion%20in%20the%20TARGET%20guideline%20by%20consulting%20content%20experts%20using%20sequential%20online%20surveys.%20The%20third%20stage%20will%20prioritise%20and%20consolidate%20key%20items%20to%20be%20included%20in%20the%20TARGET%20guideline%20at%20an%20in-person%20consensus%20meeting%20of%20TARGET%20investigators.%20The%20fourth%20stage%20will%20produce%20and%20pilot-test%20both%20the%20TARGET%20guideline%20and%20explanation%20and%20elaboration%20document%20with%20relevant%20stakeholders.%20The%20fifth%20stage%20will%20disseminate%20the%20TARGET%20guideline%20and%20resources%20via%20journals%2C%20conferences%20and%20courses.%5CnETHICS%20AND%20DISSEMINATION%3A%20Ethical%20approval%20for%20the%20survey%20has%20been%20attained%20%28HC220536%29.%20The%20TARGET%20guideline%20will%20be%20disseminated%20widely%20in%20partnership%20with%20stakeholders%20to%20maximise%20adoption%20and%20improve%20reporting%20of%20these%20studies.%22%2C%22date%22%3A%222023-09-12%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2023-074626%22%2C%22ISSN%22%3A%222044-6055%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T11%3A17%3A53Z%22%7D%7D%2C%7B%22key%22%3A%2297TK8ITG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Olago%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20Victor%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNimako%2C%20Gideon%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBartels%2C%20Lina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20Julia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20Tafadzwa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Cancer%20diagnostic%20service%20use%20in%20people%20with%20HIV%20in%20South%20Africa%3A%20a%20cross-sectional%20study.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.09.10.23295338.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.09.10.23295338%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.09.10.23295338%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cancer%20diagnostic%20service%20use%20in%20people%20with%20HIV%20in%20South%20Africa%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gideon%22%2C%22lastName%22%3A%22Nimako%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Bartels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tafadzwa%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Sengayi-Muchengeti%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20The%20objective%20of%20this%20study%20was%20to%20map%20place%20of%20cancer%20diagnosis%20in%20relation%20to%20Human%20Immunodeficiency%20Virus%20%28HIV%29%20care%20centre%20among%20people%20with%20HIV%20%28PWH%29%20within%20South%20Africa%20%28SA%29%20using%20national%20laboratory%20database.%5CnDESIGN%3A%20We%20linked%20HIV%20and%20cancer%20laboratory%20data%20from%202004-2014%20using%20supervised%20machine-learning%20algorithms.%20We%20performed%20a%20cross-sectional%20analysis%20comparing%20province%20where%20individuals%20accessed%20their%20HIV%20care%20versus%20where%20they%20had%20their%20cancer%20diagnosis.%5CnSETTING%3A%20We%20used%20laboratory%20test%20records%20related%20to%20HIV%20diagnostics%20and%20care%2C%20such%20as%20CD4%20cell%20counts%20and%20percentages%2C%20rapid%20tests%2C%20qualitative%20Polymerase%20Chain%20Reaction%20%28PCR%29%2C%20antibody%20and%20antigen%20tests%20for%20HIV%20data%20that%20was%20documented%20as%20HIV%20positive%20and%20laboratory%20diagnosed%20cancer%20records%20from%20SA.%5CnSTUDY%20POPULATION%3A%20Our%20study%20population%20consisted%20of%20HIV%20records%20from%20the%20National%20Health%20Laboratory%20Service%20%28NHLS%29%20that%20linked%20to%20cancer%20record%20at%20the%20National%20Cancer%20Registry%20%28NCR%29%20between%202004-2014.%5CnPRIMARY%20AND%20SECONDARY%20OUTCOMES%3A%20We%20linked%20HIV%20records%20from%20NHLS%20to%20cancer%20records%20at%20NCR%20in%20order%20to%20study%20the%20inherent%20characteristics%20of%20the%20population%20with%20both%20HIV%20and%20cancer.%5CnRESULTS%3A%20The%20study%20population%20was%2068%2C284%20individuals%20with%20cancer%20and%20documented%20HIV%20related%20laboratory%20test.%20The%20median%20age%20at%20cancer%20diagnosis%20was%2040%20%5BIQR%2C%2033-48%5D%20years%20for%20the%20study%20population%20with%20most%20cancers%20in%20PWH%20diagnosed%20in%20females%2070.9%25%20%5Bn%3D46%2C313%5D.%20Of%20all%20the%20PWH%20and%20cancer%2C%2025%25%20%28n%3D16%2C364%20p%20%26lt%3B%200.001%29%20sought%20treatment%20outside%20their%20province%20of%20residence%20with%2060.7%25%20%28n%3D10%2C235%29%20travelling%20to%20Gauteng.%20KZN%20had%2046.6%25%20%28n%3D4%2C107%29%20of%20its%20PWH%20getting%20cancer%20diagnosis%20in%20Gauteng.%20Western%20Cape%20had%2095%25%20%28n%3D6%2C200%29%20of%20PWH%20getting%20cancer%20diagnosis%20within%20the%20province.%5CnCONCLUSIONS%3A%20Our%20results%20showed%20health%20systems%20inequalities%20across%20provinces%20in%20South%20Africa%20with%20respect%20to%20cancer%20diagnosis.%20KZN%20for%20example%20had%20nearly%20half%20of%20the%20PWH%20getting%20cancer%20diagnosis%20outside%20the%20province%20while%20Western%20Cape%20is%20able%20to%20offer%20cancer%20diagnostic%20services%20to%20most%20of%20the%20PWH%20in%20the%20province.%20Gauteng%20is%20getting%20over%20burdened%20with%20referral%20for%20cancer%20diagnosis%20from%20other%20provinces.%20More%20effort%20is%20required%20to%20ensure%20equitable%20access%20to%20cancer%20diagnostic%20services%20within%20the%20country.%5CnARTICLE%20SUMMARY%3A%20Strengths%20and%20limitations%20of%20this%20study%3A%20We%20mapped%20the%20facilities%20of%20cancer%20diagnosis%20versus%20HIV%20care%20facilities%20for%20the%20PWH%20seeking%20cancer%20diagnosis%20in%20South%20Africa.We%20compared%20PWH%20who%20sought%20treatment%20in%20their%20province%20of%20residence%20versus%20those%20who%20sought%20treatment%20outside%20their%20province%20of%20residence.We%20used%20HIV%20care%20facility%26%23039%3Bs%20addresses%20as%20a%20proxy%20for%20place%20of%20residence%20for%20PWH.We%20did%20not%20account%20for%20movement%20due%20to%20other%20reasons%20such%20as%20migration%20for%20better%20jobs%20and%20education.%22%2C%22date%22%3A%222023-09-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.09.10.23295338%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-10-10T12%3A04%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22DRBQK4QM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hansford%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHansford%2C%20Harrison%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCashin%2C%20Aidan%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJones%2C%20Matthew%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSwanson%2C%20Sonja%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIslam%2C%20Nazrul%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Reporting%20of%20Observational%20Studies%20Explicitly%20Aiming%20to%20Emulate%20Randomized%20Trials%3A%20A%20Systematic%20Review.%20%26lt%3Bi%26gt%3BJAMA%20Network%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e2336023.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.36023%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.36023%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reporting%20of%20Observational%20Studies%20Explicitly%20Aiming%20to%20Emulate%20Randomized%20Trials%3A%20A%20Systematic%20Review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harrison%20J.%22%2C%22lastName%22%3A%22Hansford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aidan%20G.%22%2C%22lastName%22%3A%22Cashin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20D.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%20A.%22%2C%22lastName%22%3A%22Swanson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nazrul%22%2C%22lastName%22%3A%22Islam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R.%20G.%22%2C%22lastName%22%3A%22Douglas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigo%20R.%20N.%22%2C%22lastName%22%3A%22Rizzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%20J.%22%2C%22lastName%22%3A%22Devonshire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sam%20A.%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Issa%20J.%22%2C%22lastName%22%3A%22Dahabreh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbra%20A.%22%2C%22lastName%22%3A%22Dickerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xabier%22%2C%22lastName%22%3A%22Garcia-Albeniz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20M.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Lodi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margarita%22%2C%22lastName%22%3A%22Moreno-Betancur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sallie-Anne%22%2C%22lastName%22%3A%22Pearson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Schneeweiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20K.%22%2C%22lastName%22%3A%22Sharp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%20A.%22%2C%22lastName%22%3A%22Stuart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miguel%20A.%22%2C%22lastName%22%3A%22Hern%5Cu00e1n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hopin%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20H.%22%2C%22lastName%22%3A%22McAuley%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Observational%20%28nonexperimental%29%20studies%20that%20aim%20to%20emulate%20a%20randomized%20trial%20%28ie%2C%20the%20target%20trial%29%20are%20increasingly%20informing%20medical%20and%20policy%20decision-making%2C%20but%20it%20is%20unclear%20how%20these%20studies%20are%20reported%20in%20the%20literature.%20Consistent%20reporting%20is%20essential%20for%20quality%20appraisal%2C%20evidence%20synthesis%2C%20and%20translation%20of%20evidence%20to%20policy%20and%20practice.%5CnOBJECTIVE%3A%20To%20assess%20the%20reporting%20of%20observational%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial.%5CnEVIDENCE%20REVIEW%3A%20We%20searched%20Medline%2C%20Embase%2C%20PsycINFO%2C%20and%20Web%20of%20Science%20for%20observational%20studies%20published%20between%20March%202012%20and%20October%202022%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%20of%20a%20health%20or%20medical%20intervention.%20Two%20reviewers%20double-screened%20and%20-extracted%20data%20on%20study%20characteristics%2C%20key%20predefined%20components%20of%20the%20target%20trial%20protocol%20and%20its%20emulation%20%28eligibility%20criteria%2C%20treatment%20strategies%2C%20treatment%20assignment%2C%20outcome%5Bs%5D%2C%20follow-up%2C%20causal%20contrast%5Bs%5D%2C%20and%20analysis%20plan%29%2C%20and%20other%20items%20related%20to%20the%20target%20trial%20emulation.%5CnFINDINGS%3A%20A%20total%20of%20200%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%20were%20included.%20These%20studies%20included%2026%20subfields%20of%20medicine%2C%20and%20168%20%2884%25%29%20were%20published%20from%20January%202020%20to%20October%202022.%20The%20aim%20to%20emulate%20a%20target%20trial%20was%20explicit%20in%2070%20study%20titles%20%2835%25%29.%20Forty-three%20studies%20%2822%25%29%20reported%20use%20of%20a%20published%20reporting%20guideline%20%28eg%2C%20Strengthening%20the%20Reporting%20of%20Observational%20Studies%20in%20Epidemiology%29.%20Eighty-five%20studies%20%2843%25%29%20did%20not%20describe%20all%20key%20items%20of%20how%20the%20target%20trial%20was%20emulated%20and%20113%20%2857%25%29%20did%20not%20describe%20the%20protocol%20of%20the%20target%20trial%20and%20its%20emulation.%5CnCONCLUSION%20AND%20RELEVANCE%3A%20In%20this%20systematic%20review%20of%20200%20studies%20that%20explicitly%20aimed%20to%20emulate%20a%20target%20trial%2C%20reporting%20of%20how%20the%20target%20trial%20was%20emulated%20was%20inconsistent.%20A%20reporting%20guideline%20for%20studies%20explicitly%20aiming%20to%20emulate%20a%20target%20trial%20may%20improve%20the%20reporting%20of%20the%20target%20trial%20protocols%20and%20other%20aspects%20of%20these%20emulation%20attempts.%22%2C%22date%22%3A%222023-09-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamanetworkopen.2023.36023%22%2C%22ISSN%22%3A%222574-3805%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A26%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22K2ZRBLPD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Z%5Cu00fcrcher%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAbela%2C%20Irene%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStange%2C%20Madlen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDupont%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMugglin%2C%20Catrina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Alpha%20Variant%20Coronavirus%20Outbreak%20in%20a%20Nursing%20Home%20Despite%20High%20Vaccination%20Coverage%3A%20Molecular%2C%20Epidemiological%2C%20and%20Immunological%20Studies.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B77%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20537%26%23x2013%3B546.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciab1005%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciab1005%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Alpha%20Variant%20Coronavirus%20Outbreak%20in%20a%20Nursing%20Home%20Despite%20High%20Vaccination%20Coverage%3A%20Molecular%2C%20Epidemiological%2C%20and%20Immunological%20Studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%20A.%22%2C%22lastName%22%3A%22Abela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madlen%22%2C%22lastName%22%3A%22Stange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Dupont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catrina%22%2C%22lastName%22%3A%22Mugglin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Egli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Trkola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Vaccination%20may%20control%20the%20coronavirus%20disease%202019%20%28COVID-19%29%20pandemic%2C%20including%20in%20nursing%20homes%20where%20many%20high-risk%20people%20live.%20We%20conducted%20extensive%20outbreak%20investigations.%5CnMETHODS%3A%20We%20studied%20an%20outbreak%20at%20a%20nursing%20home%20in%20Switzerland%2C%20where%20the%20uptake%20of%20messenger%20RNA%20vaccines%20against%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29%20was%2082%25%20among%20residents%20as%20of%2021%20January%202021.%20After%20diagnosis%20of%20COVID-19%20in%20a%20vaccinated%20symptomatic%20healthcare%20worker%20%28HCW%29%20on%2022%20February%2C%20we%20performed%20outbreak%20investigations%20in%20house%20A%20%2847%20residents%3B%2037%20HCWs%29%2C%20using%20SARS-CoV-2-specific%20polymerase%20chain%20reaction%20testing%20of%20nasopharyngeal%20swab%20samples.%20We%20performed%20whole-genome%20sequencing%20of%20SARS-CoV-2%20and%20serological%20analyses.%5CnRESULTS%3A%20We%20identified%2017%20individuals%20with%20positive%20polymerase%20chain%20reaction%20results%2C%2010%20residents%20%285%20vaccinated%29%20and%207%20HCWs%20%283%20vaccinated%29.%20The%20median%20age%20%28interquartile%20range%29%20was%2086%20%2870-90%29%20years%20among%20residents%20and%2049%20%2829-59%29%20years%20among%20HCWs.%20Of%20the%205%20vaccinated%20residents%2C%203%20had%20mild%20disease%20and%202%20had%20no%20symptoms%2C%20whereas%20all%205%20unvaccinated%20residents%20had%20mild%20to%20severe%20disease%2C%20and%202%20died.%20Vaccine%20effectiveness%20for%20the%20prevention%20of%20infection%20among%20residents%20was%2073.0%25%20%2895%25%20confidence%20interval%2C%2024.7%25-90.1%25%29.%20The%2012%20available%20genomes%20were%20all%20alpha%20variants.%20Neutralizing%20titers%20were%20significantly%20higher%20in%20vaccinated%20individuals%20on%20reexposure%20%28%26gt%3B1%20week%20after%20diagnosis%29%20than%20in%20vaccinated%2C%20unexposed%20HCWs%20%28P%5Cu2005%3D%5Cu2005.01%29.%20Transmission%20networks%20indicated%204%20likely%20or%20possible%20transmissions%20from%20vaccinated%20to%20other%20individuals%20and%2012%20transmission%20events%20from%20unvaccinated%20individuals.%5CnCONCLUSIONS%3A%20COVID-19%20outbreaks%20can%20occur%20in%20nursing%20homes%2C%20including%20transmission%20from%20vaccinated%20persons%20to%20others.%20Outbreaks%20might%20occur%20silently%2C%20underlining%20the%20need%20for%20continued%20testing%20and%20basic%20infection%20control%20measures%20in%20these%20high-risk%20settings.%22%2C%22date%22%3A%222023-08-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciab1005%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-11-08T10%3A07%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22RZU3UQMM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderegg%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderegg%2C%20Nanina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchwab%2C%20Tiana%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBorcard%2C%20Lo%26%23xEF%3Bc%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMugglin%2C%20Catrina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKeune-D%26%23xFC%3Bbi%2C%20Bettina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Population-Based%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Whole-Genome%20Sequencing%20and%20Contact%20Tracing%20During%20the%20Coronavirus%20Disease%202019%20Pandemic%20in%20Switzerland.%20%26lt%3Bi%26gt%3BThe%20Journal%20of%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B228%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20251%26%23x2013%3B260.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiad074%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiad074%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Population-Based%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20Whole-Genome%20Sequencing%20and%20Contact%20Tracing%20During%20the%20Coronavirus%20Disease%202019%20Pandemic%20in%20Switzerland%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiana%22%2C%22lastName%22%3A%22Schwab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lo%5Cu00efc%22%2C%22lastName%22%3A%22Borcard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catrina%22%2C%22lastName%22%3A%22Mugglin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22Keune-D%5Cu00fcbi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Testing%20and%20contact%20tracing%20%28CT%29%20can%20interrupt%20transmission%20chains%20of%20SARS-CoV-2.%20Whole-genome%20sequencing%20%28WGS%29%20can%20potentially%20strengthen%20these%20investigations%20and%20provide%20insights%20on%20transmission.%5CnMETHODS%3A%20We%20included%20all%20laboratory-confirmed%20COVID-19%20cases%20diagnosed%20between%204%20June%20and%2026%20July%202021%2C%20in%20a%20Swiss%20canton.%20We%20defined%20CT%20clusters%20based%20on%20epidemiological%20links%20reported%20in%20the%20CT%20data%20and%20genomic%20clusters%20as%20sequences%20with%20no%20single-nucleotide%20polymorphism%20%28SNP%29%20differences%20between%20any%202%20pairs%20of%20sequences%20being%20compared.%20We%20assessed%20the%20agreement%20between%20CT%20clusters%20and%20genomic%20clusters.%5CnRESULTS%3A%20Of%20359%20COVID-19%20cases%2C%20213%20were%20sequenced.%20Overall%2C%20agreement%20between%20CT%20and%20genomic%20clusters%20was%20low%20%28Cohen%26%23039%3Bs%20%5Cu03ba%20%3D%200.13%29.%20Of%2024%20CT%20clusters%20with%20%5Cu22652%20sequenced%20samples%2C%209%20%2837.5%25%29%20were%20also%20linked%20based%20on%20genomic%20sequencing%20but%20in%204%20of%20these%2C%20WGS%20found%20additional%20cases%20in%20other%20CT%20clusters.%20Household%20was%20most%20often%20reported%20source%20of%20infection%20%28n%20%3D%20101%20%5B28.1%25%5D%29%20and%20home%20addresses%20coincided%20well%20with%20CT%20clusters%3A%20In%2044%20of%2054%20CT%20clusters%20containing%20%5Cu22652%20cases%20%2881.5%25%29%2C%20all%20cases%20in%20the%20cluster%20had%20the%20same%20reported%20home%20address.%20However%2C%20only%20a%20quarter%20of%20household%20transmission%20was%20confirmed%20by%20WGS%20%286%20of%2026%20genomic%20clusters%20%5B23.1%25%5D%29.%20A%20sensitivity%20analysis%20using%20%5Cu22641-SNP%20differences%20to%20define%20genomic%20clusters%20resulted%20in%20similar%20results.%5CnCONCLUSIONS%3A%20WGS%20data%20supplemented%20epidemiological%20CT%20data%2C%20supported%20the%20detection%20of%20potential%20additional%20clusters%20missed%20by%20CT%2C%20and%20identified%20misclassified%20transmissions%20and%20sources%20of%20infection.%20Household%20transmission%20was%20overestimated%20by%20CT.%22%2C%22date%22%3A%222023-08-11%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Finfdis%5C%2Fjiad074%22%2C%22ISSN%22%3A%221537-6613%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-09-07T03%3A39%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22EQBKRS4L%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22parsedDate%22%3A%222023-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGlobal%20variations%20in%20pubertal%20growth%20spurts%20in%20adolescents%20living%20with%20perinatal%20HIV%20%282023%29.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%201603%26%23x2013%3B1615.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003602%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003602%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20variations%20in%20pubertal%20growth%20spurts%20in%20adolescents%20living%20with%20perinatal%20HIV%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20To%20describe%20pubertal%20growth%20spurts%20among%20adolescents%20living%20with%20perinatally%20acquired%20HIV%20%28ALWPHIV%29%20on%20antiretroviral%20therapy%20%28ART%29.%5CnDESIGN%3A%20Observational%20data%20collected%20from%201994%20to%202015%20in%20the%20CIPHER%20global%20cohort%20collaboration.%5CnMETHODS%3A%20ALWPHIV%20who%20initiated%20ART%20age%20less%20than%2010%5Cu200ayears%20with%20at%20least%20four%20height%20measurements%20age%20at%20least%208%20years%20were%20included.%20Super%20Imposition%20by%20Translation%20And%20Rotation%20%28SITAR%29%20models%2C%20with%20parameters%20representing%20timing%20and%20intensity%20of%20the%20growth%20spurt%2C%20were%20used%20to%20describe%20growth%2C%20separately%20by%20sex.%20Associations%20between%20region%2C%20ART%20regimen%2C%20age%2C%20height-for-age%20%28HAZ%29%2C%20and%20BMI-for-age%20z%20-scores%20%28BMIz%29%20at%20ART%20initiation%20%28baseline%29%20and%20age%2010%5Cu200ayears%2C%20and%20SITAR%20parameters%20were%20explored.%5CnRESULTS%3A%20Four%20thousand%20seven%20hundred%20and%20twenty-three%20ALWPHIV%20were%20included%3A%2051%25%20from%20East%20and%20Southern%20Africa%20%28excluding%20Botswana%20and%20South%20Africa%29%2C%2017%25%20Botswana%20and%20South%20Africa%2C%206%25%20West%20and%20Central%20Africa%2C%2011%25%20Europe%20and%20North%20America%2C%2011%25%20Asia-Pacific%2C%20and%204%25%20Central%2C%20South%20America%2C%20and%20Caribbean.%20Growth%20spurts%20were%20later%20and%20least%20intense%20in%20sub-Saharan%20regions.%20In%20females%2C%20older%20baseline%20age%20and%20lower%20BMIz%20at%20baseline%20were%20associated%20with%20later%20and%20more%20intense%20growth%20spurts%3B%20lower%20HAZ%20was%20associated%20with%20later%20growth%20spurts.%20In%20males%2C%20older%20baseline%20age%20and%20lower%20HAZ%20were%20associated%20with%20later%20and%20less%20intense%20growth%20spurts%3B%20however%2C%20associations%20between%20baseline%20HAZ%20and%20timing%20varied%20by%20age.%20Lower%20HAZ%20and%20BMIz%20at%2010%5Cu200ayears%20were%20associated%20with%20later%20and%20less%20intense%20growth%20spurts%20in%20both%20sexes.%5CnCONCLUSION%3A%20ALWPHIV%20who%20started%20ART%20at%20older%20ages%20or%20already%20stunted%20were%20more%20likely%20to%20have%20delayed%20pubertal%20growth%20spurts.%20Longer-term%20follow-up%20is%20important%20to%20understand%20the%20impact%20of%20delayed%20growth.%22%2C%22date%22%3A%222023-08-01%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003602%22%2C%22ISSN%22%3A%221473-5571%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T15%3A53%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22K22SKTEE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Parcesepe%20et%20al.%22%2C%22parsedDate%22%3A%222023-08%22%2C%22numChildren%22%3A10%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BParcesepe%2C%20Angela%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStockton%2C%20Melissa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRemch%2C%20Molly%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20William%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBernard%2C%20Charlotte%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Availability%20of%20screening%20and%20treatment%20for%20common%20mental%20disorders%20in%20HIV%20clinic%20settings%3A%20data%20from%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%2C%202016-2017%20and%202020.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e26147.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26147%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26147%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Availability%20of%20screening%20and%20treatment%20for%20common%20mental%20disorders%20in%20HIV%20clinic%20settings%3A%20data%20from%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%2C%202016-2017%20and%202020%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%22%2C%22lastName%22%3A%22Stockton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Molly%22%2C%22lastName%22%3A%22Remch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%22%2C%22lastName%22%3A%22Ajeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Pape%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Minga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Kwobah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junko%22%2C%22lastName%22%3A%22Tanuma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Common%20mental%20disorders%20%28CMDs%29%20are%20highly%20prevalent%20among%20people%20with%20HIV.%20Integrating%20mental%20healthcare%20into%20HIV%20care%20may%20improve%20mental%20health%20and%20HIV%20treatment%20outcomes.%20We%20describe%20the%20reported%20availability%20of%20screening%20and%20treatment%20for%20depression%2C%20anxiety%20and%20post-traumatic%20stress%20disorder%20%28PTSD%29%20at%20global%20HIV%20treatment%20centres%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20Consortium%20in%202020%20and%20changes%20in%20availability%20at%20sites%20in%20low-%20or%20middle-income%20countries%20%28LMICs%29%20between%202016%5C%2F2017%20and%202020.%5CnMETHODS%3A%20In%202020%2C%20238%20sites%20contributing%20individual-level%20data%20to%20the%20IeDEA%20Consortium%20and%20in%202016%5C%2F2017%20a%20stratified%20random%20sample%20of%20IeDEA%20sites%20in%20LMICs%20were%20eligible%20to%20participate%20in%20site%20surveys%20on%20the%20availability%20of%20screening%20and%20treatment%20for%20CMDs.%20We%20assessed%20trends%20over%20time%20for%2068%20sites%20across%2027%20LMICs%20that%20participated%20in%20both%20surveys.%5CnRESULTS%3A%20Among%20the%20238%20sites%20eligible%20to%20participate%20in%20the%202020%20site%20survey%2C%20227%20%2895%25%29%20participated%2C%20and%20mental%20health%20screening%20and%20treatment%20data%20were%20available%20for%20223%20%2898%25%29%20sites%20across%2041%20countries.%20A%20total%20of%2095%20sites%20across%2029%20LMICs%20completed%20the%202016%5C%2F2017%20survey.%20In%202020%2C%2068%25%20of%20sites%20were%20in%20urban%20settings%2C%20and%2077%25%20were%20in%20LMICs.%20Overall%2C%2050%25%2C%2014%25%20and%2012%25%20of%20sites%20reported%20screening%20with%20a%20validated%20instrument%20for%20depression%2C%20anxiety%20and%20PTSD%2C%20respectively.%20Screening%20plus%20treatment%20in%20the%20form%20of%20counselling%20was%20available%20for%20depression%2C%20anxiety%20and%20PTSD%20at%2046%25%2C%2013%25%20and%2011%25%20of%20sites%2C%20respectively.%20Screening%20plus%20treatment%20in%20the%20form%20of%20medication%20was%20available%20for%20depression%2C%20anxiety%20and%20PTSD%20at%2036%25%2C%2011%25%20and%208%25%20of%20sites%2C%20respectively.%20Among%20sites%20that%20participated%20in%20both%20surveys%2C%20screening%20for%20depression%20was%20more%20commonly%20available%20in%202020%20than%202016%5C%2F2017%20%2875%25%20vs.%2059%25%2C%20respectively%2C%20p%20%3D%200.048%29.%5CnCONCLUSIONS%3A%20Reported%20availability%20of%20screening%20for%20depression%20increased%20among%20this%20group%20of%20IeDEA%20sites%20in%20LMICs%20between%202016%5C%2F2017%20and%202020.%20However%2C%20substantial%20gaps%20persist%20in%20the%20availability%20of%20mental%20healthcare%20at%20HIV%20treatment%20sites%20across%20global%20settings%2C%20particularly%20in%20resource-constrained%20settings.%20Implementation%20of%20sustainable%20strategies%20to%20integrate%20mental%20health%20services%20into%20HIV%20care%20is%20needed.%22%2C%22date%22%3A%222023-08%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26147%22%2C%22ISSN%22%3A%221758-2652%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222024-01-12T13%3A25%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22QZJ4MTKF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-07-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKunzekwenyika%2C%20Cordelia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManzero%2C%20Josphat%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20the%20Friendship%20Bench%20Intervention%20on%20Antiretroviral%20Therapy%20Outcomes%20and%20Mental%20Health%20Symptoms%20in%20Rural%20Zimbabwe%3A%20A%20Cluster%20Randomized%20Trial.%20%26lt%3Bi%26gt%3BJAMA%20Network%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%20%287%29%2C%20S.%20e2323205.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.23205%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1001%5C%2Fjamanetworkopen.2023.23205%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20the%20Friendship%20Bench%20Intervention%20on%20Antiretroviral%20Therapy%20Outcomes%20and%20Mental%20Health%20Symptoms%20in%20Rural%20Zimbabwe%3A%20A%20Cluster%20Randomized%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josphat%22%2C%22lastName%22%3A%22Manzero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janneke%20H.%22%2C%22lastName%22%3A%22van%20Dijk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Manhibi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Hobbins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruth%22%2C%22lastName%22%3A%22Verhey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Friendship%20Bench%20ART%20trial%20group%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Common%20mental%20disorders%20%28CMD%29%2C%20which%20include%20depression%20and%20anxiety%2C%20are%20prevalent%20among%20people%20living%20with%20HIV%20and%20are%20associated%20with%20suboptimal%20antiretroviral%20therapy%20%28ART%29%20adherence.%5CnOBJECTIVE%3A%20To%20assess%20the%20effect%20of%20a%20lay%20health%20worker-led%20psychological%20intervention%20on%20ART%20adherence%2C%20virologic%20suppression%2C%20and%20mental%20health%20symptoms.%5CnDESIGN%2C%20SETTING%2C%20AND%20PARTICIPANTS%3A%20Open-label%20pragmatic%20cluster%20trial%20with%201%3A1%20block%20randomization%20of%2016%20health%20facilities%20in%20rural%20Bikita%2C%20Zimbabwe.%20Recruitment%20occurred%20from%20October%202018%20to%20December%202019%2C%20and%20participants%20were%20followed%20up%20for%2012%20months%2C%20ending%20in%20December%202020.%20Participants%20were%20adults%20aged%2018%20years%20and%20older%2C%20who%20spoke%20English%20or%20Shona%2C%20screened%20positive%20for%20CMD%20%28Shona%20Symptoms%20Questionnaire%20%5BSSQ%5D-14%20score%20%5Cu22659%29%2C%20received%20first-line%20ART%20for%206%20or%20more%20months%2C%20had%20no%20World%20Health%20Organization%20stage%204%20disease%2C%20no%20psychosis%2C%20were%20not%20pregnant%2C%20and%20provided%20informed%20consent.%20Data%20were%20analyzed%20from%20March%202021%20to%20February%202022.%5CnINTERVENTION%3A%20The%20Friendship%20Bench%2C%20consisting%20of%206%20lay%20health%20worker-led%20weekly%20problem-solving%20therapy%20sessions%20and%20optional%20peer-led%20group%20support.%5CnMAIN%20OUTCOMES%20AND%20MEASURES%3A%20The%20primary%20outcome%20was%20mean%20adherence%20during%202%20to%206%20months%20of%20follow-up%2C%20and%20the%20secondary%20outcomes%20were%20mean%20adherence%20during%201%20to%2012%20months%20of%20follow-up%2C%20change%20in%20SSQ-14%20and%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20scores%20%283%2C%206%2C%209%2C%20and%2012%20months%29%2C%20and%20viral%20load%20suppression%20%286%20and%2012%20months%29.%5CnRESULTS%3A%20A%20total%20of%20516%20participants%20were%20recruited%20%28244%20in%20Friendship%20Bench%20and%20272%20in%20enhanced%20standard%20care%20facilities%29%3B%20438%20%2884.9%25%29%20were%20female%20and%20the%20mean%20%28SD%29%20age%20was%2045.6%20%2810.9%29%20years.%20Mean%20%28SD%29%20adherence%20between%202%20to%206%20months%20was%2089.9%25%20%2818.4%25%29%20in%20the%20Friendship%20Bench%20group%20and%2087.2%25%20%2820.1%25%29%20in%20the%20control%20group.%20The%20intervention%20had%20no%20statistically%20significant%20effect%20on%20adherence%20between%202%20to%206%20months%20%28unadjusted%20mean%20difference%2C%201.93%20percentage%20points%3B%2095%25%20CI%2C%20-1.20%20to%205.06%20percentage%20points%3B%20P%5Cu2009%3D%5Cu2009.23%29%2C%20between%20months%201%20to%2012%20%28mean%20difference%200.79%20percentage%20points%3B%2095%25%20CI%2C%20-2.14%20to%203.71%20percentage%20points%3B%20P%5Cu2009%3D%5Cu2009.60%29%2C%20or%20viral%20suppression.%20Declines%20in%20SSQ-14%20scores%20from%20baseline%20to%203%20months%20%28difference%2C%20-1.65%3B%2095%25%20CI%2C%20-3.07%20to%20-0.24%29%2C%206%20months%20%28difference%2C%20-1.57%3B%2095%25%20CI%2C%20-2.98%20to%20-0.15%29%2C%20and%209%20months%20%28difference%2C%20-1.63%3B%2095%25%20CI%2C%20-3.05%20to%20-0.22%29%20were%20greater%20in%20the%20Friendship%20Bench%20than%20the%20standard%20care%20group%20%28P%5Cu2009%26lt%3B%5Cu2009.05%29.%20There%20were%20no%20differences%20in%20the%20decline%20in%20the%20SSQ-14%20scores%20from%20baseline%20to%2012%20months%20and%20in%20declines%20in%20PHQ-9%20scores%20from%20baseline%20to%203%2C%206%2C%209%2C%20and%2012%20months.%5CnCONCLUSIONS%20AND%20RELEVANCE%3A%20In%20this%20randomized%20trial%20of%20HIV-positive%20participants%20with%20CMD%2C%20the%20Friendship%20Bench%20intervention%20had%20no%20effect%20on%20adherence%20and%20viral%20suppression%2C%20possibly%20due%20to%20the%20absence%20of%20skill-based%20adherence%20training%20and%20a%20ceiling%20effect.%5CnTRIAL%20REGISTRATION%3A%20ClinicalTrials.gov%20Identifier%3A%20NCT03704805.%22%2C%22date%22%3A%222023-07-03%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1001%5C%2Fjamanetworkopen.2023.23205%22%2C%22ISSN%22%3A%222574-3805%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-01-24T16%3A08%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22RHAAX2AX%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Person%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-16%22%2C%22numChildren%22%3A4%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerson%2C%20Anna%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCrabtree-Ramirez%2C%20Brenda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKim%2C%20Ahra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVeloso%2C%20Valdil%26%23xE9%3Ba%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaruri%2C%20Fernanda%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Cryptococcal%20Meningitis%20and%20Clinical%20Outcomes%20in%20Persons%20With%20Human%20Immunodeficiency%20Virus%3A%20A%20Global%20View.%20%26lt%3Bi%26gt%3BClinical%20Infectious%20Diseases%3A%20An%20Official%20Publication%20of%20the%20Infectious%20Diseases%20Society%20of%20America%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%202116%26%23x2013%3B2125.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad076%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciad076%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cryptococcal%20Meningitis%20and%20Clinical%20Outcomes%20in%20Persons%20With%20Human%20Immunodeficiency%20Virus%3A%20A%20Global%20View%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20K.%22%2C%22lastName%22%3A%22Person%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brenda%22%2C%22lastName%22%3A%22Crabtree-Ramirez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahra%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valdil%5Cu00e9a%22%2C%22lastName%22%3A%22Veloso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernanda%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Fox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22John%20Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darma%22%2C%22lastName%22%3A%22Imran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kinh%22%2C%22lastName%22%3A%22Van%20Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Nalitya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winnie%22%2C%22lastName%22%3A%22Muyindike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bryan%20E.%22%2C%22lastName%22%3A%22Shepherd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%20C.%22%2C%22lastName%22%3A%22McGowan%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Cryptococcal%20meningitis%20%28CM%29%20is%20a%20major%20cause%20of%20morbidity%20and%20mortality%20in%20persons%20with%20human%20immunodeficiency%20virus%20%28HIV%3B%20PWH%29.%20Little%20is%20known%20about%20CM%20outcomes%20and%20availability%20of%20diagnostic%20and%20treatment%20modalities%20globally.%5CnMETHODS%3A%20In%20this%20retrospective%20cohort%20study%2C%20we%20investigated%20CM%20incidence%20and%20all-cause%20mortality%20in%20PWH%20in%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20cohort%20from%201996%20to%202017.%20We%20estimated%20incidence%20using%20quasi-Poisson%20models%20adjusted%20for%20sex%2C%20age%2C%20calendar%20year%2C%20CD4%20cell%20count%20%28CD4%29%2C%20and%20antiretroviral%20therapy%20%28ART%29%20status.%20Mortality%20after%20CM%20diagnosis%20was%20examined%20using%20multivariable%20Cox%20models.%20A%20site%20survey%20from%202017%20assessed%20availability%20of%20CM%20diagnostic%20and%20treatment%20modalities.%5CnRESULTS%3A%20Among%20518%20852%20PWH%2C%20there%20were%203857%20cases%20of%20CM%20with%20an%20estimated%20incidence%20of%201.54%20per%201000%20person-years.%20Mortality%20over%20a%20median%20of%202.6%20years%20of%20post-CM%20diagnosis%20follow-up%20was%2031.6%25%2C%20with%2029%25%20lost%20to%20follow-up.%20In%20total%2C%202478%20%2864%25%29%20were%20diagnosed%20with%20CM%20after%20ART%20start%20with%20a%20median%20of%20253%20days%20from%20ART%20start%20to%20CM%20diagnosis.%20Older%20age%20%28hazard%20%5BHR%5D%2C%201.31%20for%2050%20vs%2035%20years%29%2C%20lower%20CD4%20%28HR%2C%201.15%20for%20200%20vs%20350%20cells%5C%2Fmm3%29%2C%20and%20earlier%20year%20of%20CM%20diagnosis%20%28HR%2C%200.51%20for%202015%20vs%202000%29%20were%20associated%20with%20higher%20mortality.%20Of%2089%20sites%2C%2034%25%20reported%20access%20to%20amphotericin%20B%3B%2012%25%20had%20access%20to%20flucytosine.%5CnCONCLUSIONS%3A%20Mortality%20after%20CM%20diagnosis%20was%20high.%20A%20substantial%20portion%20of%20CM%20cases%20occurred%20after%20ART%20start%2C%20though%20incidence%20and%20mortality%20may%20be%20higher%20than%20reported%20due%20to%20ascertainment%20bias.%20Many%20sites%20lacked%20access%20to%20recommended%20CM%20treatment.%22%2C%22date%22%3A%222023-06-16%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciad076%22%2C%22ISSN%22%3A%221537-6591%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222025-03-06T12%3A15%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22A3X487HE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kubjane%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-10%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKubjane%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOsman%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJohnson%2C%20L.%20F.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Drivers%20of%20sex%20differences%20in%20the%20South%20African%20adult%20tuberculosis%20incidence%20and%20mortality%20trends%2C%201990-2019.%20%26lt%3Bi%26gt%3BSci%20Rep%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%209487.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-36432-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-36432-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Drivers%20of%20sex%20differences%20in%20the%20South%20African%20adult%20tuberculosis%20incidence%20and%20mortality%20trends%2C%201990-2019%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kubjane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Osman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%5D%2C%22abstractNote%22%3A%22Males%20have%20higher%20tuberculosis%20incidence%20and%20mortality%20rates%20than%20females.%20This%20study%20aimed%20to%20assess%20how%20sex%20differences%20in%20tuberculosis%20incidence%20and%20mortality%20could%20be%20explained%20by%20sex%20differences%20in%20HIV%2C%20antiretroviral%20treatment%20%28ART%29%20uptake%2C%20smoking%2C%20alcohol%20abuse%2C%20undernutrition%2C%20diabetes%2C%20social%20contact%20rates%2C%20health-seeking%20patterns%2C%20and%20treatment%20discontinuation.%20We%20developed%20an%20age-sex-stratified%20dynamic%20tuberculosis%20transmission%20model%20and%20calibrated%20it%20to%20South%20African%20data.%20We%20estimated%20male-to-female%20%28M%3AF%29%20tuberculosis%20incidence%20and%20mortality%20ratios%2C%20the%20effect%20of%20the%20abovementioned%20factors%20on%20the%20M%3AF%20ratios%20and%20PAFs%20for%20the%20tuberculosis%20risk%20factors.%20Over%20the%20period%201990-2019%2C%20the%20M%3AF%20ratios%20for%20tuberculosis%20incidence%20and%20mortality%20rates%20persisted%20above%201.0%2C%20and%20the%20figures%20reached%201.70%20and%201.65%2C%20respectively%2C%20by%20the%20end%20of%202019.%20In%202019%2C%20HIV%20contributed%20greater%20increases%20in%20tuberculosis%20incidence%20among%20females%20than%20males%20%2854.5%25%20vs.%2045.6%25%29%3B%20however%2C%20females%20experienced%20more%20reductions%20due%20to%20ART%20than%20males%20%2838.3%25%20vs.%2017.5%25%29.%20PAFs%20for%20tuberculosis%20incidence%20due%20to%20alcohol%20abuse%2C%20smoking%2C%20and%20undernutrition%2C%20in%20men%20were%2051.4%25%2C%2029.5%25%2C%20and%2016.1%25%2C%20respectively%2C%20higher%20than%20females%20%2830.1%25%2C%2015.4%25%2C%20and%2010.7%25%2C%20respectively%29%3B%20the%20PAF%20due%20to%20diabetes%20was%20higher%20in%20females%20than%20males%20%2822.9%25%20vs.%2017.5%25%29.%20Lower%20health-seeking%20rates%20in%20males%20accounted%20for%20a%207%25%20higher%20mortality%20rate%20in%20men.%20The%20higher%20burden%20of%20tuberculosis%20in%20men%20highlights%20the%20need%20to%20improve%20men%26%23039%3Bs%20access%20to%20routine%20screening%20and%20ensure%20earlier%20diagnosis.%20Sustained%20efforts%20in%20providing%20ART%20remain%20critical%20in%20reducing%20HIV-associated%20tuberculosis.%20Additional%20interventions%20to%20reduce%20alcohol%20abuse%20and%20tobacco%20smoking%20are%20also%20needed.%22%2C%22date%22%3A%22Jun%2010%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-36432-6%22%2C%22ISSN%22%3A%222045-2322%20%28Electronic%29%202045-2322%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A14%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22KFNK273W%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Taghavi%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Misinzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwanahamuntu%2C%20Mulindi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoumet%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Accuracy%20of%20screening%20tests%20for%20cervical%20pre-cancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia.%20%26lt%3Bi%26gt%3BmedRxiv%26%23x202F%3B%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.05.31.23290779.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.05.31.23290779%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.05.31.23290779%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Accuracy%20of%20screening%20tests%20for%20cervical%20pre-cancer%20in%20women%20living%20with%20HIV%20in%20low-resource%20settings%3A%20a%20paired%20prospective%20study%20in%20Lusaka%2C%20Zambia.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Misinzo%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mulindi%22%2C%22lastName%22%3A%22Mwanahamuntu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Roumet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herbert%22%2C%22lastName%22%3A%22Kapesa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thamsanqa%22%2C%22lastName%22%3A%22Madliwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Rutjes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Partha%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Manasyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Bohlius%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%3A%20To%20provide%20evidence%20to%20improve%20cervical%20screening%20for%20women%20living%20with%20HIV%20%28WLHIV%29%2C%20we%20assessed%20the%20accuracy%20of%20screening%20tests%20that%20can%20be%20used%20in%20low-resource%20settings%20and%20give%20results%20at%20the%20same%20visit.%20Methods%3A%20We%20conducted%20a%20paired%2C%20prospective%20study%20among%20consecutive%20eligible%20WLHIV%2C%20aged%2018-65%20years%2C%20receiving%20cervical%20cancer%20screening%20at%20one%20hospital%20in%20Lusaka%2C%20Zambia.%20The%20histopathological%20reference%20standard%20was%20multiple%20biopsies%20taken%20at%20two%20time%20points.%20The%20target%20condition%20was%20high-grade%20cervical%20intraepithelial%20neoplasia%20%28CIN2%2B%29.%20The%20index%20tests%20were%20high-risk%20human%20papillomavirus%20detection%20%28hrHPV%2C%20Xpert%20HPV%2C%20Cepheid%29%2C%20portable%20colposcopy%20%28Gynocular%2C%20Gynius%29%2C%20and%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29.%20Accuracy%20of%20stand-alone%20and%20test%20combinations%20were%20calculated%20as%20the%20point%20estimate%20with%2095%25%20confidence%20intervals.%20A%20sensitivity%20analysis%20considered%20disease%20when%20only%20visible%20lesions%20were%20biopsied.%20Results%3A%20Among%20371%20participants%20with%20histopathological%20results%2C%2027%25%20%28101%5C%2F371%29%20women%20had%20CIN2%2B%20and%2023%25%20%2823%5C%2F101%29%20was%20not%20detected%20by%20any%20index%20test.%20Sensitivity%20and%20specificity%20for%20stand-alone%20tests%20were%3A%20hrHPV%2C%2067.3%25%20%2895%25%20CI%3A%2057.7-75.7%29%20and%2065.3%25%20%2859.4-70.7%29%3B%20Gynocular%2051.5%25%20%2841.9-61.0%29%20and%2080.0%25%20%2874.8-84.3%29%3B%20and%20VIA%2022.8%25%20%2815.7-31.9%29%20and%2092.6%25%20%2888.8-95.2%29%2C%20respectively.%20The%20combination%20of%20hrHPV%20testing%20followed%20by%20Gynocular%20had%20the%20best%20balance%20of%20sensitivity%20%2842.6%25%20%5B33.4-52.3%5D%29%20and%20specificity%20%2889.6%25%20%5B85.3-92.7%5D%29.%20All%20test%20accuracies%20improved%20in%20sensitivity%20analysis.%20Conclusion%3A%20The%20low%20accuracy%20of%20screening%20tests%20assessed%20might%20be%20explained%20by%20our%20reference%20standard%2C%20which%20reduced%20verification%20and%20misclassification%20biases.%20Better%20screening%20strategies%20for%20WLHIV%20in%20low-resource%20settings%20are%20urgently%20needed.%20Registration%20number%3A%20The%20trial%20was%20registered%20prospectively%20at%20ClinicalTrials.gov%20%28ref%3A%20NCT03931083%20%29.%20The%20study%20protocol%20has%20been%20previously%20published%2C%20and%20the%20statistical%20analysis%20plan%20can%20be%20accessed%20on%20ClinicalTrials.gov%20.%20Key%20messages%3A%20What%20is%20already%20known%20on%20this%20topic%3A%20The%202021%20World%20Health%20Organization%20guidelines%20recommend%20that%20women%20living%20with%20HIV%20%28WLHIV%29%20receive%20screening%20for%20high%20risk%20human%20papillomavirus%20high-risk%20human%20papillomavirus%20%28hrHPV%29%20genotypes%20at%20three-%20to%20five-year%20intervals%2C%20followed%20by%20a%20triage%20test%20to%20determine%20whether%20treatment%20is%20needed%20but%20this%20is%20based%20on%20low%20and%20moderate%20certainty%20evidence.What%20this%20study%20adds%3A%20This%20study%20among%20WLHIV%20in%20Lusaka%2C%20Zambia%20evaluated%20three%20screening%20tests%20that%20allow%20same-day%20treatment%3B%20hrHPV%20test%2C%20portable%20colposcopy%20%28Gynocular%29%2C%20and%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29%2C%20using%20strict%20methods%20to%20reduce%20verification%20and%20misclassification%20biases.%20The%20test%20accuracy%20of%20the%20different%20screening%20was%20poor%2C%20with%20sensitivities%20and%20specificity%20for%20stand-alone%20tests%3A%20hrHPV%2C%2067.3%25%20and%2065.3%25%3B%20Gynocular%2051.5%25%20and%2080.0%25%3B%20and%20VIA%2022.8%25%20and%2092.6%25%3B%20respectively.How%20this%20study%20might%20affect%20research%2C%20practice%20or%20policy%3A%20Our%20findings%20have%20implications%20for%20research%20and%20cervical%20cancer%20screening%20policies%20among%20WLHIV%20if%20test-%20accuracy%20in%20this%20high-risk%20population%20has%20been%20overestimated%20from%20a%20majority%20of%20exsisting%20studies%20that%20are%20affected%20by%20verification%20and%20misclassification%20biases.%20Methodologically%20robust%20studies%20are%20crucial%20to%20inform%20cervical%20cancer%20screening%20practices%20and%20policies%20for%20the%20successful%20implementation%20of%20a%20cervical%20cancer%20elimination%20plan%20in%20sub-%20Saharan%20Africa%2C%20where%2085%25%20of%20women%20with%20cervical%20cancer%20and%20HIV%20live.%22%2C%22date%22%3A%222023%20Jun%201%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.05.31.23290779%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%222JTBM5VT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dovel%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDovel%2C%20K.%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHariprasad%2C%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHubbard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhiri%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Strategies%20to%20improve%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20early%20engagement%20among%20men%20in%20sub-Saharan%20Africa%3A%20A%20scoping%20review%20of%20interventions%20in%20the%20era%20of%20universal%20treatment.%20%26lt%3Bi%26gt%3BTrop%20Med%20Int%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20454%26%23x2013%3B465.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.13880%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Ftmi.13880%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Strategies%20to%20improve%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20early%20engagement%20among%20men%20in%20sub-Saharan%20Africa%3A%20A%20scoping%20review%20of%20interventions%20in%20the%20era%20of%20universal%20treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20L.%22%2C%22lastName%22%3A%22Dovel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hariprasad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Hubbard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Phiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Choko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Abbott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Hoffman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Nichols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Gupta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Long%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20Men%20in%20sub-Saharan%20Africa%20%28SSA%29%20have%20lower%20rates%20of%20antiretroviral%20therapy%20%28ART%29%20initiation%20and%20higher%20rates%20of%20early%20default%20than%20women.%20Little%20is%20known%20about%20effective%20interventions%20to%20improve%20men%26%23039%3Bs%20outcomes.%20We%20conducted%20a%20scoping%20review%20of%20interventions%20aimed%20to%20increase%20ART%20initiation%20and%5C%2For%20early%20retention%20among%20men%20in%20SSA%20since%20universal%20treatment%20policies%20were%20implemented.%20METHODS%3A%20Three%20databases%2C%20HIV%20conference%20databases%20and%20grey%20literature%20were%20searched%20for%20studies%20published%20between%20January%202016%20to%20May%202021%20that%20reported%20on%20initiation%20and%5C%2For%20early%20retention%20among%20men.%20Eligibility%20criteria%20included%3A%20participants%20in%20SSA%2C%20data%20collected%20after%20universal%20treatment%20policies%20were%20implemented%20%282016-2021%29%2C%20quantitative%20data%20on%20ART%20initiation%20and%5C%2For%20early%20retention%20for%20males%2C%20general%20male%20population%20%28not%20exclusively%20focused%20on%20key%20populations%29%2C%20intervention%20study%20%28report%20outcomes%20for%20at%20least%20one%20non-standard%20service%20delivery%20strategy%29%2C%20and%20written%20in%20English.%20RESULTS%3A%20Of%20the%204351%20sources%20retrieved%2C%2015%20%28reporting%20on%2016%20interventions%29%20met%20inclusion%20criteria.%20Of%20the%2016%20interventions%2C%20only%20two%20%282%5C%2F16%2C%2013%25%29%20exclusively%20focused%20on%20men.%20Five%20%285%5C%2F16%2C%2031%25%29%20were%20randomised%20control%20trials%20%28RCT%29%2C%20one%20%281%5C%2F16%2C%206%25%29%20was%20a%20retrospective%20cohort%20study%2C%20and%2010%20%2810%5C%2F16%2C%2063%25%29%20did%20not%20have%20comparison%20groups.%20Thirteen%20%2813%5C%2F16%2C%2081%25%29%20interventions%20measured%20ART%20initiation%20and%20six%20%286%5C%2F16%2C%2037%25%29%20measured%20early%20retention.%20Outcome%20definitions%20and%20time%20frames%20varied%20greatly%2C%20with%20seven%20%287%5C%2F16%2C%2044%25%29%20not%20specifying%20time%20frames%20at%20all.%20Five%20types%20of%20interventions%20were%20represented%3A%20optimising%20ART%20services%20at%20health%20facilities%2C%20community-based%20ART%20services%2C%20outreach%20support%20%28such%20as%20reminders%20and%20facility%20escort%29%2C%20counselling%20and%5C%2For%20peer%20support%2C%20and%20conditional%20incentives.%20Across%20all%20intervention%20types%2C%20ART%20initiation%20rates%20ranged%20from%2027%25%20to%2097%25%20and%20early%20retention%20from%2047%25%20to%2095%25.%20CONCLUSIONS%3A%20Despite%20years%20of%20data%20of%20men%26%23039%3Bs%20suboptimal%20ART%20outcomes%2C%20there%20is%20little%20high-quality%20evidence%20on%20interventions%20to%20increase%20men%26%23039%3Bs%20ART%20initiation%20or%20early%20retention%20in%20SSA.%20Additional%20randomised%20or%20quasi-experimental%20studies%20are%20urgently%20needed.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1111%5C%2Ftmi.13880%22%2C%22ISSN%22%3A%221365-3156%20%28Electronic%29%201360-2276%20%28Print%29%201360-2276%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A18%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22JMM5FY67%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20A.%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLienhard%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Mental%20Health%2C%20ART%20Adherence%2C%20and%20Viral%20Suppression%20Among%20Adolescents%20and%20Adults%20Living%20with%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study.%20%26lt%3Bi%26gt%3BAIDS%20Behav%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B27%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%201849%26%23x2013%3B1861.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-022-03916-x%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-022-03916-x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mental%20Health%2C%20ART%20Adherence%2C%20and%20Viral%20Suppression%20Among%20Adolescents%20and%20Adults%20Living%20with%20HIV%20in%20South%20Africa%3A%20A%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Lienhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%20M.%20G.%22%2C%22lastName%22%3A%22Boshomane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Salazar-Vizcaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Nyakato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20E.%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Wainberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%5D%2C%22abstractNote%22%3A%22We%20followed%20adolescents%20and%20adults%20living%20with%20HIV%20aged%20older%20than%2015%20years%20who%20enrolled%20in%20a%20South%20African%20private-sector%20HIV%20programme%20to%20examine%20adherence%20and%20viral%20non-suppression%20%28viral%20load%20%26gt%3B%20400%20copies%5C%2FmL%29%20of%20participants%20with%20%2820%2C743%2C%2038%25%29%20and%20without%20%2833%2C635%2C%2062%25%29%20mental%20health%20diagnoses.%20Mental%20health%20diagnoses%20were%20associated%20with%20unfavourable%20adherence%20patterns.%20The%20risk%20of%20viral%20non-suppression%20was%20higher%20among%20patients%20with%20organic%20mental%20disorders%20%5Badjusted%20risk%20ratio%20%28aRR%29%201.55%2C%2095%25%20confidence%20interval%20%28CI%29%201.22-1.96%5D%2C%20substance%20use%20disorders%20%28aRR%201.53%2C%2095%25%20CI%201.19-1.97%29%2C%20serious%20mental%20disorders%20%28aRR%201.30%2C%2095%25%20CI%201.09-1.54%29%2C%20and%20depression%20%28aRR%201.19%2C%2095%25%20CI%201.10-1.28%29%20when%20compared%20with%20patients%20without%20mental%20health%20diagnoses.%20The%20risk%20of%20viral%20non-suppression%20was%20also%20higher%20among%20males%2C%20adolescents%20%2815-19%20years%29%2C%20and%20young%20adults%20%2820-24%20years%29.%20Our%20study%20highlights%20the%20need%20for%20psychosocial%20interventions%20to%20improve%20HIV%20treatment%20outcomes-particularly%20of%20adolescents%20and%20young%20adults-and%20supports%20strengthening%20mental%20health%20services%20in%20HIV%20treatment%20programmes.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10461-022-03916-x%22%2C%22ISSN%22%3A%221573-3254%20%28Electronic%29%201090-7165%20%28Print%29%201090-7165%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A17%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22ZHPVL3IM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kassanjee%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20M.%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNgwenya%2C%20O.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOsei-Yeboah%2C%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJacobs%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20COVID-19%20among%20adults%20living%20with%20HIV%3A%20correlates%20of%20mortality%20among%20public%20sector%20healthcare%20users%20in%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BJ%20Int%20AIDS%20Soc%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e26104.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26104%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26104%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22COVID-19%20among%20adults%20living%20with%20HIV%3A%20correlates%20of%20mortality%20among%20public%20sector%20healthcare%20users%20in%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%22%2C%22lastName%22%3A%22Ngwenya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Osei-Yeboah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Jacobs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Morden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Timmerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Britz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Mendelson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Taljaard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Riou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Tiffin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Zinyakatira%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20While%20a%20large%20proportion%20of%20people%20with%20HIV%20%28PWH%29%20have%20experienced%20SARS-CoV-2%20infections%2C%20there%20is%20uncertainty%20about%20the%20role%20of%20HIV%20disease%20severity%20on%20COVID-19%20outcomes%2C%20especially%20in%20lower-income%20settings.%20We%20studied%20the%20association%20of%20mortality%20with%20characteristics%20of%20HIV%20severity%20and%20management%2C%20and%20vaccination%2C%20among%20adult%20PWH.%20METHODS%3A%20We%20analysed%20observational%20cohort%20data%20on%20all%20PWH%20aged%20%26gt%3B%5C%2F%3D15%20years%20experiencing%20a%20diagnosed%20SARS-CoV-2%20infection%20%28until%20March%202022%29%2C%20who%20accessed%20public%20sector%20healthcare%20in%20the%20Western%20Cape%20province%20of%20South%20Africa.%20Logistic%20regression%20was%20used%20to%20study%20the%20association%20of%20mortality%20with%20evidence%20of%20antiretroviral%20therapy%20%28ART%29%20collection%2C%20time%20since%20first%20HIV%20evidence%2C%20CD4%20cell%20count%2C%20viral%20load%20%28among%20those%20with%20evidence%20of%20ART%20collection%29%20and%20COVID-19%20vaccination%2C%20adjusting%20for%20demographic%20characteristics%2C%20comorbidities%2C%20admission%20pressure%2C%20location%20and%20time%20period.%20RESULTS%3A%20Mortality%20occurred%20in%205.7%25%20%2895%25%20CI%3A%205.3%2C6.0%29%20of%2017%2C831%20first-diagnosed%20infections.%20Higher%20mortality%20was%20associated%20with%20lower%20recent%20CD4%2C%20no%20evidence%20of%20ART%20collection%2C%20high%20or%20unknown%20recent%20viral%20load%20and%20recent%20first%20HIV%20evidence%2C%20differentially%20by%20age.%20Vaccination%20was%20protective.%20The%20burden%20of%20comorbidities%20was%20high%2C%20and%20tuberculosis%20%28especially%20more%20recent%20episodes%20of%20tuberculosis%29%2C%20chronic%20kidney%20disease%2C%20diabetes%20and%20hypertension%20were%20associated%20with%20higher%20mortality%2C%20more%20strongly%20in%20younger%20adults.%20CONCLUSIONS%3A%20Mortality%20was%20strongly%20associated%20with%20suboptimal%20HIV%20control%2C%20and%20the%20prevalence%20of%20these%20risk%20factors%20increased%20in%20later%20COVID-19%20waves.%20It%20remains%20a%20public%20health%20priority%20to%20ensure%20PWH%20are%20on%20suppressive%20ART%20and%20vaccinated%2C%20and%20manage%20any%20disruptions%20in%20care%20that%20occurred%20during%20the%20pandemic.%20The%20diagnosis%20and%20management%20of%20comorbidities%2C%20including%20for%20tuberculosis%2C%20should%20be%20optimized.%22%2C%22date%22%3A%22Jun%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26104%22%2C%22ISSN%22%3A%221758-2652%20%28Electronic%29%201758-2652%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A14%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22662YB787%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Cipriani%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCipriani%2C%20Andrea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSeedat%2C%20Soraya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMilligan%2C%20Lea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSalanti%2C%20Georgia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMacleod%2C%20Malcolm%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20New%20living%20evidence%20resource%20of%20human%20and%20non-human%20studies%20for%20early%20intervention%20and%20research%20prioritisation%20in%20anxiety%2C%20depression%20and%20psychosis.%20%26lt%3Bi%26gt%3BBMJ%20Mental%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20e300759.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjment-2023-300759%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjment-2023-300759%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22New%20living%20evidence%20resource%20of%20human%20and%20non-human%20studies%20for%20early%20intervention%20and%20research%20prioritisation%20in%20anxiety%2C%20depression%20and%20psychosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Cipriani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Milligan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georgia%22%2C%22lastName%22%3A%22Salanti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malcolm%22%2C%22lastName%22%3A%22Macleod%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janna%22%2C%22lastName%22%3A%22Hastings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Thomas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Michie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Toshi%20A.%22%2C%22lastName%22%3A%22Furukawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Gilbert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karla%22%2C%22lastName%22%3A%22Soares-Weiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Moreno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Leucht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Parisa%22%2C%22lastName%22%3A%22Mansoori%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20M.%22%2C%22lastName%22%3A%22Barker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Spyridon%22%2C%22lastName%22%3A%22Siafis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%20Giuseppe%22%2C%22lastName%22%3A%22Ostinelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22McCutcheon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simonne%22%2C%22lastName%22%3A%22Wright%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matilda%22%2C%22lastName%22%3A%22Simpson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olufisayo%22%2C%22lastName%22%3A%22Elugbadebo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Virginia%22%2C%22lastName%22%3A%22Chiocchia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomy%22%2C%22lastName%22%3A%22Tonia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rania%22%2C%22lastName%22%3A%22Elgarf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayse%22%2C%22lastName%22%3A%22Kurtulmus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Sena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ouma%22%2C%22lastName%22%3A%22Simple%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niall%22%2C%22lastName%22%3A%22Boyce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjuli%22%2C%22lastName%22%3A%22Sharma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miranda%22%2C%22lastName%22%3A%22Wolpert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Potts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%20H.%22%2C%22lastName%22%3A%22Elliott%22%7D%5D%2C%22abstractNote%22%3A%22In%20anxiety%2C%20depression%20and%20psychosis%2C%20there%20has%20been%20frustratingly%20slow%20progress%20in%20developing%20novel%20therapies%20that%20make%20a%20substantial%20difference%20in%20practice%2C%20as%20well%20as%20in%20predicting%20which%20treatments%20will%20work%20for%20whom%20and%20in%20what%20contexts.%20To%20intervene%20early%20in%20the%20process%20and%20deliver%20optimal%20care%20to%20patients%2C%20we%20need%20to%20understand%20the%20underlying%20mechanisms%20of%20mental%20health%20conditions%2C%20develop%20safe%20and%20effective%20interventions%20that%20target%20these%20mechanisms%2C%20and%20improve%20our%20capabilities%20in%20timely%20diagnosis%20and%20reliable%20prediction%20of%20symptom%20trajectories.%20Better%20synthesis%20of%20existing%20evidence%20is%20one%20way%20to%20reduce%20waste%20and%20improve%20efficiency%20in%20research%20towards%20these%20ends.%20Living%20systematic%20reviews%20produce%20rigorous%2C%20up-to-date%20and%20informative%20evidence%20summaries%20that%20are%20particularly%20important%20where%20research%20is%20emerging%20rapidly%2C%20current%20evidence%20is%20uncertain%20and%20new%20findings%20might%20change%20policy%20or%20practice.%20Global%20Alliance%20for%20Living%20Evidence%20on%20aNxiety%2C%20depressiOn%20and%20pSychosis%20%28GALENOS%29%20aims%20to%20tackle%20the%20challenges%20of%20mental%20health%20science%20research%20by%20cataloguing%20and%20evaluating%20the%20full%20spectrum%20of%20relevant%20scientific%20research%20including%20both%20human%20and%20preclinical%20studies.%20GALENOS%20will%20also%20allow%20the%20mental%20health%20community-including%20patients%2C%20carers%2C%20clinicians%2C%20researchers%20and%20funders-to%20better%20identify%20the%20research%20questions%20that%20most%20urgently%20need%20to%20be%20answered.%20By%20creating%20open-access%20datasets%20and%20outputs%20in%20a%20state-of-the-art%20online%20resource%2C%20GALENOS%20will%20help%20identify%20promising%20signals%20early%20in%20the%20research%20process.%20This%20will%20accelerate%20translation%20from%20discovery%20science%20into%20effective%20new%20interventions%20for%20anxiety%2C%20depression%20and%20psychosis%2C%20ready%20to%20be%20translated%20in%20clinical%20practice%20across%20the%20world.%22%2C%22date%22%3A%222023-06%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjment-2023-300759%22%2C%22ISSN%22%3A%222755-9734%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A15%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22KN2YW9HN%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pretsch%20et%20al.%22%2C%22parsedDate%22%3A%222023-06%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPretsch%2C%20Peyton%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSpees%2C%20Lisa%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrewer%2C%20Noel%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHudgens%2C%20Michael%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSanusi%2C%20Busola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20HPV%20self-collection%20kits%20on%20cervical%20cancer%20screening%20uptake%20among%20under-screened%20women%20from%20low-income%20US%20backgrounds%20%28MBMT-3%29%3A%20a%20phase%203%2C%20open-label%2C%20randomised%20controlled%20trial.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B8%26lt%3B%5C%2Fi%26gt%3B%20%286%29%2C%20S.%20e411%26%23x2013%3Be421.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2468-2667%2823%2900076-2%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2468-2667%2823%2900076-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20HPV%20self-collection%20kits%20on%20cervical%20cancer%20screening%20uptake%20among%20under-screened%20women%20from%20low-income%20US%20backgrounds%20%28MBMT-3%29%3A%20a%20phase%203%2C%20open-label%2C%20randomised%20controlled%20trial.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peyton%20K.%22%2C%22lastName%22%3A%22Pretsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%20P.%22%2C%22lastName%22%3A%22Spees%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noel%20T.%22%2C%22lastName%22%3A%22Brewer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20G.%22%2C%22lastName%22%3A%22Hudgens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Busola%22%2C%22lastName%22%3A%22Sanusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elyse%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20L.%22%2C%22lastName%22%3A%22Jackson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lynn%22%2C%22lastName%22%3A%22Barclay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20B.%22%2C%22lastName%22%3A%22Wheeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%20S.%22%2C%22lastName%22%3A%22Smith%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Most%20cervical%20cancer%20in%20the%20USA%20occurs%20in%20under-screened%20women.%20The%20My%20Body%2C%20My%20Test-3%20%28MBMT-3%29%20trial%20sought%20to%20assess%20the%20efficacy%20of%20mailed%20human%20papillomavirus%20%28HPV%29%20self-collection%20kits%20with%20appointment-scheduling%20assistance%20to%20increase%20uptake%20of%20cervical%20cancer%20screening%20among%20under-screened%20women%20from%20low-income%20backgrounds%20compared%20with%20scheduling%20assistance%20alone.%20METHODS%3A%20MBMT-3%20is%20a%20phase%203%2C%20open-%20label%2C%20two-arm%2C%20randomised%20controlled%20trial.%20Participants%20were%20recruited%20from%2022%20counties%20in%20North%20Carolina%20state%2C%20USA%2C%20and%20we%20partnered%20with%2021%20clinics%20across%20these%20counties.%20Participants%20were%20eligible%20for%20inclusion%20if%20they%20were%20aged%2025-64%20years%2C%20had%20an%20intact%20cervix%2C%20were%20uninsured%20or%20enrolled%20in%20Medicaid%20or%20Medicare%2C%20had%20an%20income%20of%20250%25%20or%20less%20of%20the%20US%20Federal%20Poverty%20Level%2C%20were%20living%20within%20the%20catchment%20area%20of%20a%20trial-%20associated%20clinic%2C%20and%20were%20overdue%20for%20screening%20%28ie%2C%20Papanicolaou%20test%20%26gt%3B%5C%2F%3D4%20years%20ago%20or%20high-risk%20HPV%20test%20%26gt%3B%5C%2F%3D6%20years%20ago%29.%20Participants%20were%20randomly%20assigned%20%282%3A1%29%20to%20receive%20a%20mailed%20HPV%20self-collection%20kit%20and%20assistance%20for%20scheduling%20a%20free%20screening%20appointment%20%28intervention%20group%29%20or%20to%20receive%20scheduling%20assistance%20alone%20%28control%20group%29.%20Randomisation%20was%20conducted%20by%20county%20using%20permuted%20blocks%20of%20nine%20patients%20and%20assignment%20to%20group%20was%20not%20masked.%20Participants%20in%20the%20intervention%20group%20were%20mailed%20HPV%20self-collection%20kits%20to%20collect%20a%20cervical-vaginal%20sample%20and%20return%20it%20by%20mail%20for%20testing.%20Samples%20were%20tested%20with%20the%20Aptima%20HPV%20assay%20%28Hologic%2C%20San%20Diego%2C%20CA%2C%20USA%29%2C%20and%20participants%20were%20informed%20of%20high-risk%20HPV%20results%20by%20telephone%20call.%20Trial%20staff%20made%20up%20to%20three%20telephone%20call%20attempts%20to%20provide%20scheduling%20assistance%20for%20in-clinic%20screening%20for%20all%20participants.%20The%20primary%20outcome%20was%20cervical%20cancer%20screening%20uptake%20%28ie%2C%20attending%20an%20in-clinic%20screening%20appointment%20or%20testing%20negative%20for%20high-risk%20HPV%20with%20a%20returned%20self-collected%20sample%29%20within%206%20months%20of%20enrolment%20in%20the%20intention-to-treat%20population.%20This%20trial%20is%20registered%20with%20ClinicalTrials.gov%2C%20NCT02651883%2C%20and%20has%20been%20completed.%20FINDINGS%3A%20Recruitment%20occurred%20between%20April%2011%2C%202016%2C%20and%20Dec%2016%2C%202019.%204256%20women%20contacted%20the%20trial%20to%20participate%2C%20of%20whom%20899%20%2821%25%29%20were%20eligible%20for%20inclusion%20and%20697%20%2878%25%29%20returned%20consent%20forms.%20Of%20those%20who%20consented%2C%20461%20%2866%25%29%20women%20were%20randomly%20assigned%20to%20the%20intervention%20group%20and%20236%20%2834%25%29%20women%20were%20randomly%20assigned%20to%20the%20control%20group.%20We%20excluded%2032%20ineligible%20women%20post-randomisation%2C%20leaving%20665%20for%20primary%20analysis.%20Screening%20uptake%20was%20higher%20in%20the%20intervention%20group%20%28317%20%5B72%25%5D%20of%20438%29%20than%20control%20group%20%2885%20%5B37%25%5D%20of%20227%3B%20risk%20ratio%201.93%2C%2095%25%20CI%201.62-2.31%29.%20Among%20intervention%20participants%2C%20341%20%2878%25%29%20of%20438%20returned%20a%20self-%20collection%20kit.%20Three%20participants%20reported%20hurt%20or%20injury%20when%20using%20the%20self-collection%20kit%3B%20no%20participants%20withdrew%20due%20to%20adverse%20effects.%20INTERPRETATION%3A%20Among%20under-screened%20women%20from%20low-income%20backgrounds%2C%20mailed%20HPV%20self-collection%20kits%20with%20scheduling%20assistance%20led%20to%20greater%20uptake%20of%20cervical%20cancer%20screening%20than%20scheduling%20assistance%20alone.%20At-%20home%20HPV%20self-collection%20testing%20has%20the%20potential%20to%20increase%20screening%20uptake%20among%20under-screened%20women.%20FUNDING%3A%20National%20Cancer%20Institute.%22%2C%22date%22%3A%222023%20Jun%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1016%5C%2FS2468-2667%2823%2900076-2%22%2C%22ISSN%22%3A%222468-2667%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22TTF9I5PE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222023-05%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZurcher%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJent%2C%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBittel%2C%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFurrer%2C%20L.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20SARS-CoV-2%20transmission%20with%20and%20without%20mask%20wearing%20or%20air%20cleaners%20in%20schools%20in%20Switzerland%3A%20A%20modeling%20study%20of%20epidemiological%2C%20environmental%2C%20and%20molecular%20data.%20%26lt%3Bi%26gt%3BPLoS%20Med%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B20%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20e1004226.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004226%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004226%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SARS-CoV-2%20transmission%20with%20and%20without%20mask%20wearing%20or%20air%20cleaners%20in%20schools%20in%20Switzerland%3A%20A%20modeling%20study%20of%20epidemiological%2C%20environmental%2C%20and%20molecular%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Zurcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Jent%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Bittel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Hascher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Growing%20evidence%20suggests%20an%20important%20contribution%20of%20airborne%20transmission%20to%20the%20overall%20spread%20of%20Severe%20Acute%20Respiratory%20Syndrome%20Coronavirus%202%20%28SARS-CoV-2%29%2C%20in%20particular%20via%20smaller%20particles%20called%20aerosols.%20However%2C%20the%20contribution%20of%20school%20children%20to%20SARS-CoV-2%20transmission%20remains%20uncertain.%20The%20aim%20of%20this%20study%20was%20to%20assess%20transmission%20of%20airborne%20respiratory%20infections%20and%20the%20association%20with%20infection%20control%20measures%20in%20schools%20using%20a%20multiple-measurement%20approach.%20METHODS%20AND%20FINDINGS%3A%20We%20collected%20epidemiological%20%28cases%20of%20Coronavirus%20Disease%202019%20%28COVID-19%29%29%2C%20environmental%20%28CO2%2C%20aerosol%20and%20particle%20concentrations%29%2C%20and%20molecular%20data%20%28bioaerosol%20and%20saliva%20samples%29%20over%207%20weeks%20from%20January%20to%20March%202022%20%28Omicron%20wave%29%20in%202%20secondary%20schools%20%28n%20%3D%2090%2C%20average%2018%20students%5C%2Fclassroom%29%20in%20Switzerland.%20We%20analyzed%20changes%20in%20environmental%20and%20molecular%20characteristics%20between%20different%20study%20conditions%20%28no%20intervention%2C%20mask%20wearing%2C%20air%20cleaners%29.%20Analyses%20of%20environmental%20changes%20were%20adjusted%20for%20different%20ventilation%2C%20the%20number%20of%20students%20in%20class%2C%20school%20and%20weekday%20effects.%20We%20modeled%20disease%20transmission%20using%20a%20semi-mechanistic%20Bayesian%20hierarchical%20model%2C%20adjusting%20for%20absent%20students%20and%20community%20transmission.%20Molecular%20analysis%20of%20saliva%20%2821%5C%2F262%20positive%29%20and%20airborne%20samples%20%2810%5C%2F130%29%20detected%20SARS-CoV-2%20throughout%20the%20study%20%28weekly%20average%20viral%20concentration%200.6%20copies%5C%2FL%29%20and%20occasionally%20other%20respiratory%20viruses.%20Overall%20daily%20average%20CO2%20levels%20were%201%2C064%20%2B%5C%2F-%20232%20ppm%20%28%2B%5C%2F-%20standard%20deviation%29.%20Daily%20average%20aerosol%20number%20concentrations%20without%20interventions%20were%20177%20%2B%5C%2F-%20109%201%5C%2Fcm3%20and%20decreased%20by%2069%25%20%2895%25%20CrI%2042%25%20to%2086%25%29%20with%20mask%20mandates%20and%2039%25%20%2895%25%20CrI%204%25%20to%2069%25%29%20with%20air%20cleaners.%20Compared%20to%20no%20intervention%2C%20the%20transmission%20risk%20was%20lower%20with%20mask%20mandates%20%28adjusted%20odds%20ratio%200.19%2C%2095%25%20CrI%200.09%20to%200.38%29%20and%20comparable%20with%20air%20cleaners%20%281.00%2C%2095%25%20CrI%200.15%20to%206.51%29.%20Study%20limitations%20include%20possible%20confounding%20by%20period%20as%20the%20number%20of%20susceptible%20students%20declined%20over%20time.%20Furthermore%2C%20airborne%20detection%20of%20pathogens%20document%20exposure%20but%20not%20necessarily%20transmission.%20CONCLUSIONS%3A%20Molecular%20detection%20of%20airborne%20and%20human%20SARS-CoV-2%20indicated%20sustained%20transmission%20in%20schools.%20Mask%20mandates%20were%20associated%20with%20greater%20reductions%20in%20aerosol%20concentrations%20than%20air%20cleaners%20and%20with%20lower%20transmission.%20Our%20multiple-measurement%20approach%20could%20be%20used%20to%20continuously%20monitor%20transmission%20risk%20of%20respiratory%20infections%20and%20the%20effectiveness%20of%20infection%20control%20measures%20in%20schools%20and%20other%20congregate%20settings.%22%2C%22date%22%3A%22May%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pmed.1004226%22%2C%22ISSN%22%3A%221549-1676%20%28Electronic%29%201549-1277%20%28Print%29%201549-1277%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T14%3A20%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22CKQ753WT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-17%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Y.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuchengeti%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOlago%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDhokotera%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBohlius%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Age%20and%20Cancer%20Incidence%20in%205.2%20Million%20People%20With%20Human%20Immunodeficiency%20Virus%20%28HIV%29%3A%20The%20South%20African%20HIV%20Cancer%20Match%20Study.%20%26lt%3Bi%26gt%3BClin%20Infect%20Dis%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%201440%26%23x2013%3B1448.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac925%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac925%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Age%20and%20Cancer%20Incidence%20in%205.2%20Million%20People%20With%20Human%20Immunodeficiency%20Virus%20%28HIV%29%3A%20The%20South%20African%20HIV%20Cancer%20Match%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Y.%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Olago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Dhokotera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Bohlius%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Old%20age%20is%20an%20important%20risk%20factor%20for%20developing%20cancer%2C%20but%20few%20data%20exist%20on%20this%20association%20in%20people%20with%20human%20immunodeficiency%20virus%20%28HIV%2C%20PWH%29%20in%20sub-Saharan%20Africa.%20METHODS%3A%20The%20South%20African%20HIV%20Cancer%20Match%20study%20is%20a%20nationwide%20cohort%20of%20PWH%20based%20on%20a%20linkage%20between%20HIV-related%20laboratory%20records%20from%20the%20National%20Health%20Laboratory%20Service%20and%20cancer%20diagnoses%20from%20the%20National%20Cancer%20Registry%20for%202004-2014.%20We%20included%20PWH%20who%20had%20HIV-related%20tests%20on%20separate%20days.%20Using%20natural%20splines%2C%20we%20modeled%20cancer%20incidence%20rates%20as%20a%20function%20of%20age.%20RESULTS%3A%20We%20included%205%20222%20827%20PWH%20with%2029%20580%20incident%20cancer%20diagnoses-most%20commonly%20cervical%20cancer%20%28n%20%3D%207418%29%2C%20Kaposi%20sarcoma%20%28n%20%3D%206380%29%2C%20and%20breast%20cancer%20%28n%20%3D%202748%29.%20In%20young%20PWH%2C%20the%20incidence%20rates%20for%20infection-related%20cancers%20were%20substantially%20higher%20than%20for%20infection-unrelated%20cancers.%20At%20age%2040%20years%2C%20the%20most%20frequent%20cancer%20was%20cervical%20cancer%20in%20female%20and%20Kaposi%20sarcoma%20in%20male%20PWH.%20Thereafter%2C%20the%20rates%20of%20infection-unrelated%20cancers%20increased%20steeply%2C%20particularly%20among%20male%20PWH%2C%20where%20prostate%20cancer%20became%20the%20most%20frequent%20cancer%20type%20at%20older%20age.%20Whereas%20Kaposi%20sarcoma%20rates%20peaked%20at%2034%20years%20%28101%5C%2F100%20000%20person-years%29%20in%20male%20PWH%2C%20cervical%20cancer%20remained%20the%20most%20frequent%20cancer%20among%20older%20female%20PWH.%20CONCLUSIONS%3A%20Infection-related%20cancers%20are%20common%20in%20PWH%20in%20South%20Africa%2C%20but%20rates%20of%20infection-unrelated%20cancers%20overtook%20those%20of%20infection-related%20cancers%20after%20age%2054%20years%20in%20the%20overall%20study%20population.%20As%20PWH%20in%20South%20Africa%20live%20longer%2C%20prevention%20and%20early%20detection%20of%20infection-unrelated%20cancers%20becomes%20increasingly%20important.%20Meanwhile%2C%20control%20strategies%20for%20infection-related%20cancers%2C%20especially%20cervical%20cancer%2C%20remain%20essential.%22%2C%22date%22%3A%22Apr%2017%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac925%22%2C%22ISSN%22%3A%221537-6591%20%28Electronic%29%201058-4838%20%28Print%29%201058-4838%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A10%3A31Z%22%7D%7D%2C%7B%22key%22%3A%223QZXXMYY%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Loosli%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BOkhai%2C%20Hajra%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKusejko%2C%20Katharina%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20sHIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20ART%3A%20Collaborative%20analysis%20of%20cohort%20studies.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.04.05.23288183.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.04.05.23288183%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.04.05.23288183%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22sHIV-1%20drug%20resistance%20in%20people%20on%20dolutegravir-based%20ART%3A%20Collaborative%20analysis%20of%20cohort%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajra%22%2C%22lastName%22%3A%22Okhai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Kusejko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Mouton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pantxika%22%2C%22lastName%22%3A%22Bellecave%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ard%22%2C%22lastName%22%3A%22van%20Sighem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Stecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonella%22%2C%22lastName%22%3A%22d%27Arminio%20Monforte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20John%22%2C%22lastName%22%3A%22Gill%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%20A.%22%2C%22lastName%22%3A%22Sabin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20A.%20C.%22%2C%22lastName%22%3A%22Sterne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%22%2C%22lastName%22%3A%22Kouyos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20widespread%20use%20of%20the%20integrase%20strand%20transfer%20inhibitor%20%28INSTI%29%20dolutegravir%20%28DTG%29%20in%20first-%20and%20second-line%20antiretroviral%20therapy%20%28ART%29%20may%20facilitate%20emerging%20resistance.%20We%20combined%20data%20from%20HIV%20cohorts%20to%20examine%20patterns%20of%20drug%20resistance%20mutations%20%28DRMs%29%20and%20identify%20risk%20factors%20for%20DTG%20resistance.%5CnMETHODS%3A%20Eight%20cohorts%20from%20Canada%2C%20Europe%2C%20and%20South%20Africa%20contributed%20data%20on%20individuals%20with%20genotypic%20resistance%20testing%20on%20DTG-based%20ART.%20Resistance%20levels%20were%20categorised%20using%20the%20Stanford%20algorithm.%20We%20identified%20risk%20factors%20for%20resistance%20using%20mixed-effects%20ordinal%20logistic%20regression%20models.%5CnRESULTS%3A%20We%20included%20750%20people%20with%20genotypic%20resistance%20testing%20on%20DTG-based%20ART%20between%202013%20and%202022.%20Most%20had%20HIV%20subtype%20B%20%28N%3D444%2C%2059%5Cu00b72%25%29%20and%20were%20treatment-experienced%3B%20134%20%2817.9%25%29%20were%20on%20DTG%20dual%20and%2019%20%282.5%25%29%20on%20DTG%20monotherapy.%20INSTI%20DRMs%20were%20detected%20in%20100%20%2813%5Cu00b73%25%29%20individuals%3B%2021%20%282%5Cu00b78%25%29%20had%20more%20than%20one%20mutation.%20Most%20%28N%3D713%2C%2095%5Cu00b71%25%29%20were%20susceptible%20to%20DTG%2C%208%20%281%5Cu00b71%25%29%20had%20potential-low%2C%205%20%280%5Cu00b77%25%29%20low%2C%2018%20%282%5Cu00b74%25%29%20intermediate%20and%206%20%280%5Cu00b78%25%29%20high-level%20DTG%20resistance.%20The%20risk%20of%20DTG%20resistance%20was%20higher%20on%20DTG%20monotherapy%20%28adjusted%20odds%20ratio%20%28aOR%29%2037%5Cu00b725%2C%2095%25%20CI%2011%5Cu00b717%20to%20124%5Cu00b72%29%20and%20DTG%20lamivudine%20dual%20therapy%20%28aOR%206%5Cu00b759%2C%2095%25%20CI%201%5Cu00b770%20to%2025%5Cu00b755%29%20compared%20to%20combination%20ART%2C%20and%20higher%20in%20the%20presence%20of%20potential-low%5C%2Flow%20%28aOR%204.62%2C%2095%25%20CI%201.24%20to%2017.2%29%20or%20intermediate%5C%2Fhigh-level%20%28aOR%207%5Cu00b701%2C%2095%25%20CI%202%5Cu00b752%20to%2019%5Cu00b748%29%20nucleoside%20reverse%20transcriptase%20inhibitors%20%28NRTI%29%20resistance.%20Viral%20load%20on%20DTG%20showed%20a%20trend%20towards%20increased%20DTG%20resistance%20%28aOR%201%5Cu00b742%2C%2095%25%20CI%200%5Cu00b792%20to%202%5Cu00b719%20per%20standard%20deviation%20of%20log10%20area%20under%20the%20viral%20load%20curve%29.%5CnINTERPRETATION%3A%20Among%20people%20experiencing%20virological%20failure%20on%20DTG-based%20ART%2C%20INSTI%20DRMs%20were%20uncommon%2C%20and%20DTG%20resistance%20was%20rare.%20DTG%20monotherapy%20and%20NRTI%20resistance%20substantially%20increased%20the%20risk%20for%20DTG%20resistance%2C%20which%20is%20of%20concern%2C%20notably%20in%20resource-limited%20settings.%22%2C%22date%22%3A%222023-04-05%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.04.05.23288183%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T16%3A29%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22MC2VDBK4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222023-04-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20K.%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFord%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Ongoing%20High%20Prevalence%20of%20Severe%20Immune%20Suppression%20Among%20Children%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BJ%20Acquir%20Immune%20Defic%20Syndr%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B92%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20273%26%23x2013%3B280.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003137%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003137%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ongoing%20High%20Prevalence%20of%20Severe%20Immune%20Suppression%20Among%20Children%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20G.%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Among%20children%20in%20Southern%20Africa%20severe%20immune%20suppression%20%28SIS%29%20has%20declined%2C%20but%20most%20continue%20to%20initiate%20antiretroviral%20therapy%20%28ART%29%20with%20SIS.%20SETTING%3A%20Using%20data%20from%20South%20Africa%2C%20we%20describe%20SIS%20at%20ART%20start%20and%20on%20ART%20between%202007%20and%202020%2C%20among%20children%20%26lt%3B5%20years%20with%20a%20CD4%25%5C%2Fcell%20count%20at%20ART%20start%20and%20%26gt%3B%5C%2F%3D1%20subsequent%20measure.%20METHODS%3A%20Gap%20in%20care%20was%20defined%20as%20%26gt%3B9%20months%20without%20a%20recorded%20visit.%20We%20defined%20SIS%20according%20to%20age%20and%20CD4%25%5C%2Fcell%20count.%20A%20multistate%20model%20was%20used%20to%20estimate%20transition%20probabilities%20between%205%20states%3A%20SIS%20on%20ART%3B%20Stable%2C%20not%20SIS%3B%20Early%20Gap%2C%20commencing%20%26lt%3B9%20months%20from%20ART%20start%3B%20Late%20Gap%2C%20commencing%20%26gt%3B%5C%2F%3D9%20months%20on%20ART%3B%20and%20Death.%20RESULTS%3A%20Among%202536%20children%2C%2070%25%20had%20SIS%20at%20ART%20start%2C%20and%2036%25%20experienced%20SIS%20on%20ART.%20An%20increasing%20proportion%20were%20age%20%26lt%3B1%20year%20at%20ART%20initiation%20%282007-2009%3A%2043%25%20to%202013-2020%3A%2055%25%29.%20Increasingly%2C%20SIS%20on%20ART%20occurred%20after%20a%20gap%2C%20in%20those%20with%20SIS%20on%20ART%20for%20%26gt%3B1%20year%2C%20and%20after%20a%20period%20of%20unknown%20immune%20status.%20Later%20year%20of%20ART%20initiation%20was%20associated%20with%20reduced%20transition%20from%20SIS%20on%20ART%20to%20Stable.%20Infants%20and%20those%20initiating%20ART%20with%20SIS%20were%20more%20likely%20to%20transition%20from%20Stable%20to%20SIS.%20Viremia%20strongly%20predicted%20death%20from%20both%20the%20on%20ART%20states.%20CONCLUSIONS%3A%20Increasingly%20SIS%20occurred%20among%20ART-experienced%20children.%20Those%20starting%20ART%20with%20SIS%20and%20during%20infancy%20remained%20especially%20vulnerable%20to%20SIS%20once%20on%20treatment.%20Managing%20ART%20in%20these%20children%20may%20be%20more%20complex%20and%20further%20reducing%20AIDS-related%20mortality%20is%20likely%20to%20remain%20challenging.%22%2C%22date%22%3A%22Apr%201%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003137%22%2C%22ISSN%22%3A%221944-7884%20%28Electronic%29%201525-4135%20%28Print%29%201525-4135%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A11%3A32Z%22%7D%7D%2C%7B%22key%22%3A%2235XYKA8G%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zwyer%20et%20al.%22%2C%22parsedDate%22%3A%222023-04%22%2C%22numChildren%22%3A8%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZwyer%2C%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRutaihwa%2C%20L.%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWindels%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHella%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMenardo%2C%20F.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Back-to-Africa%20introductions%20of%20Mycobacterium%20tuberculosis%20as%20the%20main%20cause%20of%20tuberculosis%20in%20Dar%20es%20Salaam%2C%20Tanzania.%20%26lt%3Bi%26gt%3BPLoS%20Pathog%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e1010893.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.ppat.1010893%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.ppat.1010893%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Back-to-Africa%20introductions%20of%20Mycobacterium%20tuberculosis%20as%20the%20main%20cause%20of%20tuberculosis%20in%20Dar%20es%20Salaam%2C%20Tanzania%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Zwyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20K.%22%2C%22lastName%22%3A%22Rutaihwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Windels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Hella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Menardo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Sasamalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Sommer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Schmulling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Borrell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Reinhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Dotsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Hiza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Stritt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Sikalengo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20C.%22%2C%22lastName%22%3A%22De%20Jong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Kato-Maeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Jugheli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20D.%22%2C%22lastName%22%3A%22Ernst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Niemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Jeljeli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Rakotosamimanana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Yeboah-Manu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Asare%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Malla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%20Y.%22%2C%22lastName%22%3A%22Dou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Zetola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20J.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Cox%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%20J.%22%2C%22lastName%22%3A%22Carter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Gnokoro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Gotuzzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Abimiku%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Z.%20M.%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Fellay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Portevin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Reither%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Stadler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Gagneux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Brites%22%7D%5D%2C%22abstractNote%22%3A%22In%20settings%20with%20high%20tuberculosis%20%28TB%29%20endemicity%2C%20distinct%20genotypes%20of%20the%20Mycobacterium%20tuberculosis%20complex%20%28MTBC%29%20often%20differ%20in%20prevalence.%20However%2C%20the%20factors%20leading%20to%20these%20differences%20remain%20poorly%20understood.%20Here%20we%20studied%20the%20MTBC%20population%20in%20Dar%20es%20Salaam%2C%20Tanzania%20over%20a%20six-year%20period%2C%20using%201%2C082%20unique%20patient-derived%20MTBC%20whole-genome%20sequences%20%28WGS%29%20and%20associated%20clinical%20data.%20We%20show%20that%20the%20TB%20epidemic%20in%20Dar%20es%20Salaam%20is%20dominated%20by%20multiple%20MTBC%20genotypes%20introduced%20to%20Tanzania%20from%20different%20parts%20of%20the%20world%20during%20the%20last%20300%20years.%20The%20most%20common%20MTBC%20genotypes%20deriving%20from%20these%20introductions%20exhibited%20differences%20in%20transmission%20rates%20and%20in%20the%20duration%20of%20the%20infectious%20period%2C%20but%20little%20differences%20in%20overall%20fitness%2C%20as%20measured%20by%20the%20effective%20reproductive%20number.%20Moreover%2C%20measures%20of%20disease%20severity%20and%20bacterial%20load%20indicated%20no%20differences%20in%20virulence%20between%20these%20genotypes%20during%20active%20TB.%20Instead%2C%20the%20combination%20of%20an%20early%20introduction%20and%20a%20high%20transmission%20rate%20accounted%20for%20the%20high%20prevalence%20of%20L3.1.1%2C%20the%20most%20dominant%20MTBC%20genotype%20in%20this%20setting.%20Yet%2C%20a%20longer%20co-existence%20with%20the%20host%20population%20did%20not%20always%20result%20in%20a%20higher%20transmission%20rate%2C%20suggesting%20that%20distinct%20life-history%20traits%20have%20evolved%20in%20the%20different%20MTBC%20genotypes.%20Taken%20together%2C%20our%20results%20point%20to%20bacterial%20factors%20as%20important%20determinants%20of%20the%20TB%20epidemic%20in%20Dar%20es%20Salaam.%22%2C%22date%22%3A%22Apr%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.ppat.1010893%22%2C%22ISSN%22%3A%221553-7374%20%28Electronic%29%201553-7366%20%28Print%29%201553-7366%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A06%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22SF5ZU36U%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vreeman%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-13%22%2C%22numChildren%22%3A14%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVreeman%2C%20R.%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYiannoutsos%2C%20C.%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYusoff%2C%20N.%20K.%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Global%20HIV%20prevention%2C%20care%20and%20treatment%20services%20for%20children%3A%20a%20cross-sectional%20survey%20from%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e069399.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2022-069399%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2022-069399%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20HIV%20prevention%2C%20care%20and%20treatment%20services%20for%20children%3A%20a%20cross-sectional%20survey%20from%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20C.%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%20K.%20N.%22%2C%22lastName%22%3A%22Yusoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Ofner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Lumbiganon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%20C.%22%2C%22lastName%22%3A%22de%20Menezes%20Succi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22O.%20E.%22%2C%22lastName%22%3A%22Takassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Scanlon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22%22%2C%22lastName%22%3A%22IeDea%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20To%20assess%20access%20children%20with%20HIV%20have%20to%20comprehensive%20HIV%20care%20services%2C%20to%20longitudinally%20evaluate%20the%20implementation%20and%20scale-up%20of%20services%2C%20and%20to%20use%20site%20services%20and%20clinical%20cohort%20data%20to%20explore%20whether%20access%20to%20these%20services%20influences%20retention%20in%20care.%20METHODS%3A%20A%20cross-sectional%20standardised%20survey%20was%20completed%20in%202014-2015%20by%20sites%20providing%20paediatric%20HIV%20care%20across%20regions%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20We%20developed%20a%20comprehensiveness%20score%20based%20on%20the%20WHO%26%23039%3Bs%20nine%20categories%20of%20essential%20services%20to%20categorise%20sites%20as%20%26%23039%3Blow%26%23039%3B%20%280-5%29%2C%20%26%23039%3Bmedium%26%23039%3B%2C%20%286-7%29%20or%20%26%23039%3Bhigh%26%23039%3B%20%288-9%29.%20When%20available%2C%20comprehensiveness%20scores%20were%20compared%20with%20scores%20from%20a%202009%20survey.%20We%20used%20patient-level%20data%20with%20site%20services%20to%20investigate%20the%20relationship%20between%20the%20comprehensiveness%20of%20services%20and%20retention.%20RESULTS%3A%20Survey%20data%20from%20174%20IeDEA%20sites%20in%2032%20countries%20were%20analysed.%20Of%20the%20WHO%20essential%20services%2C%20sites%20were%20most%20likely%20to%20offer%20antiretroviral%20therapy%20%28ART%29%20provision%20and%20counselling%20%28n%3D173%3B%2099%25%29%2C%20co-trimoxazole%20prophylaxis%20%28168%3B%2097%25%29%2C%20prevention%20of%20perinatal%20transmission%20services%20%28167%3B%2096%25%29%2C%20outreach%20for%20patient%20engagement%20and%20follow-up%20%28166%3B%2095%25%29%2C%20CD4%20cell%20count%20testing%20%28126%3B%2088%25%29%2C%20tuberculosis%20screening%20%28151%3B%2087%25%29%20and%20select%20immunisation%20services%20%28126%3B%2072%25%29.%20Sites%20were%20less%20likely%20to%20offer%20nutrition%5C%2Ffood%20support%20%2897%3B%2056%25%29%2C%20viral%20load%20testing%20%2899%3B%2069%25%29%20and%20HIV%20counselling%20and%20testing%20%2869%3B%2040%25%29.%2010%25%20of%20sites%20rated%20%26%23039%3Blow%26%23039%3B%2C%2059%25%20%26%23039%3Bmedium%26%23039%3B%20and%2031%25%20%26%23039%3Bhigh%26%23039%3B%20in%20the%20comprehensiveness%20score.%20The%20mean%20comprehensiveness%20of%20services%20score%20increased%20significantly%20from%205.6%20in%202009%20to%207.3%20in%202014%20%28p%26lt%3B0.001%3B%20n%3D30%29.%20Patient-level%20analysis%20of%20lost%20to%20follow-up%20after%20ART%20initiation%20estimated%20the%20hazard%20was%20highest%20in%20sites%20rated%20%26%23039%3Blow%26%23039%3B%20and%20lowest%20in%20sites%20rated%20%26%23039%3Bhigh%26%23039%3B.%20CONCLUSION%3A%20This%20global%20assessment%20suggests%20the%20potential%20care%20impact%20of%20scaling-up%20and%20sustaining%20comprehensive%20paediatric%20HIV%20services.%20Meeting%20recommendations%20for%20comprehensive%20HIV%20services%20should%20remain%20a%20global%20priority.%22%2C%22date%22%3A%22Mar%2013%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2022-069399%22%2C%22ISSN%22%3A%222044-6055%20%28Electronic%29%202044-6055%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A07%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22RDYHKG64%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIyun%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20B.%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20H.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFerreira%2C%20T.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Hospitalization%20among%20infants%20who%20initiate%20antiretroviral%20therapy%20before%203%20months%20of%20age.%20%26lt%3Bi%26gt%3BAIDS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20435%26%23x2013%3B445.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003422%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003422%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hospitalization%20among%20infants%20who%20initiate%20antiretroviral%20therapy%20before%203%20months%20of%20age%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Iyun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Ferreira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dea%20Sa%22%2C%22lastName%22%3A%22Ie%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Studies%20examining%20hospitalization%20among%20infants%20with%20HIV%20in%20resource-limited%20settings%2C%20in%20the%20context%20of%20early%20infant%20diagnosis%20and%20early%20antiretroviral%20therapy%20%28ART%29%20initiation%2C%20are%20limited.%20METHODS%3A%20We%20used%20routinely%20collected%20data%20on%20infants%20who%20initiated%20ART%20aged%20%26lt%3B3%20months%20%28Western%20Cape%20province%2C%20South%20Africa%3B%202013-2017%29%20to%20describe%20hospitalization%20from%20birth%20until%2012%20months%20post-ART%20initiation.%20Record%20reviews%20were%20additionally%20performed%20at%20three%20tertiary-level%20facilities.%20We%20used%20mixed-effects%20Poisson%20regression%20to%20examine%20factors%20associated%20with%20hospitalization.%20RESULTS%3A%20Among%20840%20infants%2C%20579%20%2869%25%29%20were%20hospitalized%3B%2036%25%20had%20%26gt%3B1%20hospitalization.%20Median%20age%20at%20ART%20initiation%20decreased%20from%2057%20days%20%28interquartile%20range%20%5BIQR%5D%2022-74%3B%202013-2015%29%20to%2019%20days%20%28IQR%205-54%3B%202016-2017%29.%20Early%20neonatal%20hospitalization%20%28age%20%26lt%3B7%20days%29%20occurred%20in%20271%20infants%20%2832%25%29%20and%20represented%2024%25%20of%20hospitalizations%20%28272%5C%2F1131%29.%20Overall%2C%20443%20infants%20%2853%25%29%20were%20hospitalized%20at%20age%20%26gt%3B%5C%2F%3D7%20days%2C%20including%2013%25%20with%20hospitalizations%20pre-ART%20initiation%2C%2015%25%20pre%20and%20post-ART%20initiation%20and%2025%25%20post-ART%20initiation.%20Excluding%20early%20neonatal%20hospitalizations%2C%20initiating%20ART%20at%20older%20age%20vs.%20age%20%26lt%3B1%20week%20was%20associated%20with%20higher%20hospitalization%20rates%3A%20adjusted%20incidence%20rate%20ratios%20%2895%25%20confidence%20interval%29%20were%201.86%20%281.31-2.64%29%3B%202.31%20%281.62-3.29%29%20and%202.47%20%281.76-3.46%29%20if%20ART%20initiation%20age%20was%201-4%20weeks%3B%205-8%20weeks%20and%209-12%20weeks%20respectively.%20Among%20infants%20whose%20hospital%20records%20were%20reviewed%2C%20reasons%20for%20early%20neonatal%20hospitalizations%20mostly%20related%20to%20prematurity%20or%20low%20birthweight%20%28n%20%3D%2046%5C%2F60%3B%2077%25%29%20whereas%20hospitalizations%20at%20age%20%26gt%3B%5C%2F%3D7%20days%20were%20mostly%20due%20to%20infections%20%28n%20%3D%20206%5C%2F243%3B%2085%25%29.%20CONCLUSIONS%3A%20Earlier%20ART%20initiation%20is%20associated%20with%20lower%20hospitalization%20rates.%20High%20hospitalization%20rates%2C%20despite%20initiation%20age%20%26lt%3B3%20months%2C%20is%20concerning.%22%2C%22date%22%3A%22Mar%201%202023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003422%22%2C%22ISSN%22%3A%221473-5571%20%28Electronic%29%200269-9370%20%28Print%29%200269-9370%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T14%3A20%3A55Z%22%7D%7D%2C%7B%22key%22%3A%2279FNT5LD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20G.%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEuvrard%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderegg%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoulle%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BArendse%2C%20K.%20D.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Advanced%20HIV%20disease%20and%20engagement%20in%20care%20among%20patients%20on%20antiretroviral%20therapy%20in%20South%20Africa%3A%20results%20from%20a%20multi-state%20model.%20%26lt%3Bi%26gt%3BAIDS%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B37%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20513%26%23x2013%3B522.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003442%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000003442%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Advanced%20HIV%20disease%20and%20engagement%20in%20care%20among%20patients%20on%20antiretroviral%20therapy%20in%20South%20Africa%3A%20results%20from%20a%20multi-state%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%20E.%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20D.%22%2C%22lastName%22%3A%22Arendse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22von%20der%20Heyden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Despite%20improved%20access%20to%20antiretroviral%20therapy%20%28ART%29%20for%20people%20with%20HIV%20%28PWH%29%2C%20HIV%20continues%20to%20contribute%20considerably%20to%20morbidity%20and%20mortality.%20Increasingly%2C%20advanced%20HIV%20disease%20%28AHD%29%20is%20found%20among%20PWH%20who%20are%20ART-experienced.%20DESIGN%3A%20Using%20a%20multi-state%20model%20we%20examined%20associations%20between%20engagement%20with%20care%20and%20AHD%20on%20ART%20in%20South%20Africa.%20METHODS%3A%20Using%20data%20from%20IeDEA%20Southern%20Africa%2C%20we%20included%20PWH%20from%20South%20Africa%2C%20initiating%20ART%20from%202004%20to%202017%20aged%20more%20than%205%20years%20with%20a%20CD4%2B%20cell%20count%20at%20ART%20start%20and%20at%20least%20one%20subsequent%20measure.%20We%20defined%20a%20gap%20as%20no%20visit%20for%20at%20least%2018%20months.%20Five%20states%20were%20defined%3A%20%26%23039%3BAHD%20on%20ART%26%23039%3B%20%28CD4%2B%20cell%20count%20%26lt%3B200%20cells%5C%2Fmul%29%2C%20%26%23039%3BClinically%20Stable%20on%20ART%26%23039%3B%20%28CD4%2B%20cell%20count%20%26gt%3B%5C%2F%3D200%20or%20if%20no%20CD4%2B%20cell%20count%2C%20viral%20load%20%26lt%3B1000%20copies%5C%2Fml%29%2C%20%26%23039%3BEarly%20Gap%26%23039%3B%20%28commencing%20%26lt%3B%5C%2F%3D18%20months%20from%20ART%20start%29%2C%20%26%23039%3BLate%20Gap%26%23039%3B%20%28commencing%20%26gt%3B18%20months%20from%20ART%20start%29%20and%20%26%23039%3BDeath%26%23039%3B.%20RESULTS%3A%20Among%2032%20452%20PWH%2C%20men%20and%20those%20aged%2015-25%20years%20were%20more%20likely%20to%20progress%20to%20unfavourable%20states.%20Later%20years%20of%20ART%20start%20were%20associated%20with%20a%20lower%20probability%20of%20transitioning%20from%20AHD%20to%20clinically%20stable%2C%20increasing%20the%20risk%20of%20death%20following%20AHD.%20In%20stratified%20analyses%2C%20those%20starting%20ART%20with%20AHD%20in%20later%20years%20were%20more%20likely%20to%20re-engage%20in%20care%20with%20AHD%20following%20a%20gap%20and%20to%20die%20following%20AHD%20on%20ART.%20CONCLUSION%3A%20In%20more%20recent%20years%2C%20those%20with%20AHD%20on%20ART%20were%20more%20likely%20to%20die%2C%20and%20AHD%20at%20re-engagement%20in%20care%20increased.%20To%20further%20reduce%20HIV-related%20mortality%2C%20efforts%20to%20address%20the%20challenges%20facing%20these%20more%20vulnerable%20patients%20are%20needed.%22%2C%22date%22%3A%22Mar%201%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000003442%22%2C%22ISSN%22%3A%221473-5571%20%28Electronic%29%200269-9370%20%28Print%29%200269-9370%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A11%3A51Z%22%7D%7D%2C%7B%22key%22%3A%222DGQGUPD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWettstein%2C%20Anja%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVieira%2C%20Cristina%20Mesa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Life-years%20lost%20associated%20with%20mental%20illness%3A%20a%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%20%26lt%3Bi%26gt%3BmedRxiv%26%23x202F%3B%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.01.19.23284778.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.19.23284778%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.19.23284778%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life-years%20lost%20associated%20with%20mental%20illness%3A%20a%20cohort%20study%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Wettstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%20Mesa%22%2C%22lastName%22%3A%22Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chanwyn%22%2C%22lastName%22%3A%22Williams%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Schomaker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22Importance%3A%20People%20with%20mental%20illness%20have%20a%20reduced%20life%20expectancy%2C%20but%20the%20extent%20of%20the%20mortality%20gap%20and%20the%20contribution%20of%20natural%20and%20unnatural%20causes%20to%20excess%20mortality%20among%20people%20with%20mental%20illness%20in%20South%20Africa%20are%20unknown.%20Objective%3A%20To%20quantify%20excess%20mortality%20due%20to%20natural%20and%20unnatural%20causes%20associated%20with%20mental%20illness.%20Design%20setting%20and%20participants%3A%20Cohort%20study%20using%20reimbursement%20claims%20and%20vital%20registration%20of%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%2C%20aged%2015-84%20years%20and%20covered%20by%20medical%20insurance%20at%20any%20point%20between%20January%201%2C%202011%2C%20and%20June%2030%2C%202020.%20Exposures%3A%20ICD-10%20diagnoses%20of%20mental%20disorders%20including%20organic%2C%20substance%20use%2C%20psychotic%2C%20mood%2C%20anxiety%2C%20eating%2C%20personality%2C%20and%20developmental%20disorders.%20Outcomes%3A%20Mortality%20from%20natural%2C%20unnatural%2C%20unknown%20and%20all%20causes%2C%20as%20measured%20by%20the%20life-years%20lost%20%28LYL%29%20metric.%20Results%3A%20We%20followed%201%20070%20183%20beneficiaries%20%2851.7%25%20female%2C%20median%20age%2036.1%20years%20for%20a%20median%20duration%20of%203.0%20years%2C%20of%20whom%20282%20926%20%2826.4%25%29%20received%20mental%20health%20diagnoses%20and%2027%20640%20%282.6%25%29%20died.%20Life%20expectancy%20of%20people%20with%20mental%20health%20diagnoses%20was%203.83%20years%20%2895%25%20CI%203.58-4.10%29%20shorter%20for%20men%20and%202.19%20years%20%281.97-2.41%29%20shorter%20for%20women.%20Excess%20mortality%20varied%20by%20sex%20and%20diagnosis%2C%20ranging%20from%2011.50%20LYL%20%2895%25%20CI%209.79-13.07%29%20among%20men%20with%20alcohol%20use%20disorder%20to%200.87%20LYL%20%280.40-1.43%29%20among%20women%20with%20generalised%20anxiety%20disorder.%20Most%20LYL%20were%20attributable%20to%20natural%20causes%20%283.42%20among%20men%20and%201.94%20among%20women%29.%20A%20considerable%20number%20of%20LYL%20were%20attributable%20to%20unnatural%20causes%20among%20men%20with%20bipolar%20%281.52%29%20or%20substance%20use%20%282.45%29%20disorder.%20Conclusions%20and%20Relevance%3A%20The%20burden%20of%20premature%20mortality%20among%20persons%20with%20mental%20disorders%20in%20South%20Africa%20is%20high.%20Our%20findings%20support%20implementing%20interventions%20for%20prevention%2C%20early%20detection%2C%20and%20treatment%20of%20physical%20comorbidities%20among%20people%20with%20mental%20disorders.%20Suicide%20prevention%20and%20substance%20use%20treatment%20programmes%20are%20needed%20to%20reduce%20excess%20mortality%20from%20unnatural%20causes%2C%20especially%20among%20men.%20Key%20points%3A%20Question%3A%20How%20much%20shorter%20is%20the%20life%20expectancy%20of%20people%20with%20mental%20illness%20compared%20to%20the%20general%20population%20and%20how%20many%20life%20years%20are%20lost%20due%20to%20natural%20and%20unnatural%20causes%20of%20death%3FFindings%3A%20The%20life%20expectancy%20of%20people%20with%20mental%20health%20diagnoses%20was%203.83%20years%20shorter%20for%20men%20and%202.19%20years%20shorter%20for%20women.%20Most%20excess%20life%20years%20lost%20were%20attributable%20to%20natural%20causes%20%283.42%20among%20men%20and%201.94%20among%20women%29.%20However%2C%20bipolar%20and%20substance%20use%20disorders%20were%20associated%20with%20considerable%20premature%20mortality%20from%20unnatural%20causes.Meaning%3A%20Our%20findings%20support%20the%20implementation%20of%20interventions%20for%20improving%20the%20physical%20health%20of%20people%20with%20mental%20illness%20and%20targeted%20suicide%20prevention%20and%20substance%20use%20treatment%20programmes.%22%2C%22date%22%3A%222023%20Feb%202%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.01.19.23284778%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22K663J73M%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Waal%20et%20al.%22%2C%22parsedDate%22%3A%222023-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Waal%2C%20Renee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-Gunter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20Nosisa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Abacavir%20safety%20and%20effectiveness%20in%20young%20infants%20with%20HIV%20in%20South%20African%20observational%20cohorts.%20%26lt%3Bi%26gt%3BAntiviral%20Therapy%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%2013596535231168480.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F13596535231168480%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F13596535231168480%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Abacavir%20safety%20and%20effectiveness%20in%20young%20infants%20with%20HIV%20in%20South%20African%20observational%20cohorts.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renee%22%2C%22lastName%22%3A%22de%20Waal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Gunter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Tanser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20WHO%20guidelines%20recommend%20abacavir%20in%20first-line%20antiretroviral%20treatment%20for%20children%20and%20neonates.%20However%2C%20there%20is%20no%20approved%20dose%20%26lt%3B3%20months%20of%20age%2C%20and%20data%20in%20neonates%20are%20limited.%20METHODS%3A%20We%20included%20infants%20who%20initiated%20ART%20aged%20%26lt%3B3%20months%2C%20between%202006%20and%202019%2C%20in%20nine%20South%20African%20cohorts.%20In%20those%20who%20received%20abacavir%20or%20zidovudine%2C%20we%20described%20antiretroviral%20discontinuation%20rates%3B%20and%206-%20and%2012-month%20viral%20suppression%20%28%26lt%3B400%20copies%5C%2FmL%29.%20We%20compared%20infants%20aged%20%26lt%3B28%20and%20%26gt%3B%5C%2F%3D28%20days%2C%20those%20weighing%20%26lt%3B3%20and%20%26gt%3B%5C%2F%3D3%20kg.%20RESULTS%3A%20Overall%20837%5C%2F1643%20infants%20%2851%25%29%20received%20abacavir%20and%20443%20%2827%25%29%20received%20zidovudine.%20Median%20%28interquartile%20range%2C%20IQR%29%20age%20was%2052%20days%20%2823-71%29%2C%20CD4%20percentage%20was%2027.9%20%2819.2-38.0%29%2C%20and%20weight%20was%204.0%20kg%20%283.0-4.7%29%20at%20ART%20initiation.%20In%20those%20with%20%26gt%3B%5C%2F%3D1%20month%26%23039%3Bs%20follow-up%2C%20100%5C%2F718%20%2814%25%29%20infants%20discontinued%20abacavir%2C%20at%20a%20median%20of%2017.5%20months%20%28IQR%206.5-39.5%29.%20Abacavir%20discontinuations%20did%20not%20differ%20by%20age%20or%20weight%20category%20%28p%20%3D%200.4%20and%200.2%2C%20respectively%29%3B%20and%20were%20less%20frequent%20than%20zidovudine%20discontinuations%20%28adjusted%20hazard%20ratio%200.14%2C%2095%25%20confidence%20interval%200.10-0.20%29.%20Viral%20suppression%20at%2012%20months%20occurred%20in%2043%5C%2F79%20%2854%25%29%20and%20130%5C%2F250%20%2852%25%29%20of%20those%20who%20started%20abacavir%20aged%20%26lt%3B28%20and%20%26gt%3B%5C%2F%3D28%20days%2C%20respectively%20%28p%20%3D%200.8%29%3B%2011%5C%2F19%20%2858%25%29%20and%2031%5C%2F60%20%2852%25%29%20in%20those%20who%20weighed%20%26lt%3B3%20and%20%26gt%3B%5C%2F%3D3%20kg%2C%20respectively%20%28p%20%3D%200.6%29%3B%20and%20174%5C%2F329%20%2853%25%29%20in%20those%20on%20abacavir%20versus%2077%5C%2F138%20%2856%25%29%20in%20those%20on%20zidovudine%20%28adjusted%20odds%20ratio%201.8%2C%2095%25%20confidence%20interval%201.0-3.2%29.%20CONCLUSION%3A%20Our%20data%20suggest%20that%20abacavir%20may%20be%20used%20safely%20in%20infants%20%26lt%3B28%20days%20old%20or%20who%20weigh%20%26lt%3B3%20kg.%22%2C%22date%22%3A%222023%20Feb%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1177%5C%2F13596535231168480%22%2C%22ISSN%22%3A%222040-2058%201359-6535%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-06T11%3A18%3A48Z%22%7D%7D%2C%7B%22key%22%3A%223JXGHVXS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-22%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKunzekwenyika%2C%20Cordelia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BManzero%2C%20Josphat%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHossmann%2C%20Stefanie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLimacher%2C%20Andreas%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Effect%20of%20the%20Friendship%20Bench%20intervention%20on%20antiretroviral%20therapy%20outcomes%20and%20mental%20health%20symptoms%20in%20rural%20Zimbabwe%3A%20A%20cluster%20randomized%20trial.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202023.01.21.23284784.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.21.23284784%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.01.21.23284784%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20the%20Friendship%20Bench%20intervention%20on%20antiretroviral%20therapy%20outcomes%20and%20mental%20health%20symptoms%20in%20rural%20Zimbabwe%3A%20A%20cluster%20randomized%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josphat%22%2C%22lastName%22%3A%22Manzero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Limacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janneke%20H.%22%2C%22lastName%22%3A%22van%20Dijk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Manhibi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Per%22%2C%22lastName%22%3A%22von%20Groote%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Hobbins%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruth%22%2C%22lastName%22%3A%22Verhey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Friendship%20Bench%20ART%20trial%20group%22%7D%5D%2C%22abstractNote%22%3A%22IMPORTANCE%3A%20Common%20mental%20disorders%20%28CMD%29%20are%20prevalent%20in%20people%20living%20with%20HIV%20and%20associated%20with%20suboptimal%20antiretroviral%20therapy%20%28ART%29%20adherence.%5CnOBJECTIVE%3A%20To%20assess%20the%20effect%20of%20a%20lay%20health%20worker-led%20psychological%20intervention%20on%20adherence%20to%20ART%2C%20virologic%20suppression%20and%20mental%20health%20symptoms.%5CnDESIGN%3A%20Pragmatic%20cluster%20trial%20with%20block%20randomization%20of%20health%20facilities.%20Treatment%20assignment%20was%20known%20to%20participants%2C%20providers%2C%20evaluators%2C%20and%20data%20analysts.%20Recruitment%20started%20in%20October%202018%20and%20the%20last%20follow-up%20visit%20was%20done%20in%20December%202020.%20Participants%20were%20followed%20up%20for%2012%20months.%5CnSETTING%3A%20Sixteen%20public%20health%20care%20facilities%20in%20Bikita%2C%20a%20rural%20district%20in%20Masvingo%20Province%2C%20about%20300%20km%20south%20of%20Harare.%5CnPARTICIPANTS%3A%20Men%20and%20non-pregnant%20women%20aged%2018%20years%20or%20older%20who%20spoke%20English%20or%20Shona%2C%20screened%20positive%20for%20CMD%20%28Shona%20Symptoms%20Questionnaire%20%5BSSQ%5D-14%20score%20%5Cu00e2%5Cu2030%5Cu00a59%29%2C%20had%20received%20first-line%20ART%20for%20at%20least%20six%20months%2C%20had%20no%20WHO%20clinical%20stage%204%20disease%2C%20no%20psychotic%20symptoms%2C%20and%20gave%20informed%20consent.%5CnINTERVENTION%3A%20The%20Friendship%20Bench%2C%20a%20lay%20health%20worker-led%20intervention%20consisting%20of%20six%20weekly%20individual%20counselling%20sessions%20of%20problem-solving%20therapy%20and%20optional%20peer-led%20group%20support.%5CnMAIN%20OUTCOMES%20AND%20MEASURES%3A%20The%20primary%20outcome%20was%20Medication%20Event%20Monitoring%20System%20%28MEMS%29%20mean%20adherence%20between%202-6%20months%20of%20follow-up.%20Secondary%20outcomes%20included%20mean%20adherence%20between%201-12%20months%2C%20change%20from%20baseline%20SSQ-14%20and%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%20score%20at%203%2C%206%2C%209%2C%20and%2012%20months%20and%20change%20in%20viral%20load%20suppression%20%28viral%20load%20%26lt%3B1000%20copies%20per%20mL%29%20at%20months%206%20and%2012.%5CnRESULTS%3A%20We%20recruited%20516%20participants%2C%20244%20in%20Friendship%20bench%20and%20272%20in%20standard%20care%20facilities.%20The%20mean%20age%20was%2045.6%20years%20%28SD%2010.9%29%2C%20and%20most%20participants%20were%20women%20%2884.9%25%29.%20In%20the%20Friendship%20Bench%20group%2C%2088.1%25%20of%20participants%20attended%20all%20six%20individual%20counselling%20sessions.%20Rates%20of%20adherence%20%28%26gt%3B85%25%29%20and%20virologic%20suppression%20%28%26gt%3B90%25%29%20were%20high%20in%20both%20groups.%20The%20intervention%20had%20no%20statistically%20significant%20effect%20on%20adherence%20or%20viral%20suppression.%20Declines%20in%20SSQ-14%20scores%20from%20baseline%20to%203%20months%20%28-1.65%2C%2095%25%20CI%20-3.07%20to%20-0.24%29%2C%206%20months%20%28-1.57%2C%2095%25%20CI%20-2.98%20to%20-0.15%29%2C%20and%209%20months%20%28-1.63%2C%2095%25%20CI%20-3.05%20to%20-0.22%29%20were%20greater%20in%20the%20Friendship%20Bench%20than%20the%20standard%20care%20group%20%28p%26lt%3B0.05%29.%20There%20were%20no%20differences%20in%20the%20decline%20in%20the%20SSQ-14%20scores%20from%20baseline%20to%2012%20months%20and%20in%20declines%20in%20PHQ-9%20scores%20from%20baseline%20to%203%2C%206%2C%209%2C%20and%2012%20months.%5CnCONCLUSIONS%20AND%20RELEVANCE%3A%20The%20Friendship%20Bench%20intervention%20is%20a%20feasible%20and%20acceptable%20approach%20to%20closing%20the%20treatment%20gap%20in%20mental%20health%20care%20in%20rural%20Zimbabwe.%20The%20intervention%20improved%20CMD%20symptoms%20but%20the%20intervention%20effect%20was%20smaller%20than%20previously%20shown%20in%20an%20urban%20setting.%20The%20intervention%20had%20no%20effect%20on%20adherence%20and%20viral%20suppression%2C%20possibly%20due%20to%20the%20absence%20of%20skill-based%20adherence%20training%20and%20ceiling%20effect.%5CnTRIAL%20REGISTRATION%3A%20ClinicalTrials.gov%20Identifier%3A%20NCT03704805.%5CnKEY%20POINTS%3A%20Question%3A%20Does%20the%20Friendship%20Bench%20intervention%20improve%20antiretroviral%20therapy%20%28ART%29%20adherence%2C%20viral%20suppression%20and%20mental%20health%20symptoms%20in%20people%20living%20with%20HIV%20in%20rural%20Zimbabwe%3FFindings%3A%20In%20this%20cluster-randomized%20trial%2C%20participants%20in%20the%20intervention%20group%20had%20a%20significantly%20greater%20decrease%20in%20symptoms%20of%20common%20mental%20disorders%20than%20those%20in%20the%20control%20group%2C%20but%20the%20intervention%20showed%20no%20significant%20effect%20on%20antiretroviral%20therapy%20%28ART%29%20adherence%20or%20viral%20suppression.Meaning%3A%20The%20intervention%20did%20not%20affect%20adherence%20and%20viral%20suppression%20and%20the%20effect%20of%20the%20intervention%20on%20mental%20health%20symptoms%20was%20smaller%20than%20previously%20shown.%22%2C%22date%22%3A%222023-01-22%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.01.21.23284784%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-17T15%3A45%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22DQZY2PUS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ross%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-06%22%2C%22numChildren%22%3A16%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20J.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFatti%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJaquet%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTanon%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Same-Day%20Antiretroviral%20Therapy%20Initiation%20as%20a%20Predictor%20of%20Loss%20to%20Follow-up%20and%20Viral%20Suppression%20Among%20People%20With%20Human%20Immunodeficiency%20Virus%20in%20Sub-Saharan%20Africa.%20%26lt%3Bi%26gt%3BClin%20Infect%20Dis%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B76%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2039%26%23x2013%3B47.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac759%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcid%5C%2Fciac759%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Same-Day%20Antiretroviral%20Therapy%20Initiation%20as%20a%20Predictor%20of%20Loss%20to%20Follow-up%20and%20Viral%20Suppression%20Among%20People%20With%20Human%20Immunodeficiency%20Virus%20in%20Sub-Saharan%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Tanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Castelnuovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20M.%22%2C%22lastName%22%3A%22Anastos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Yotebieng%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Treat-All%20guidelines%20recommend%20initiation%20of%20antiretroviral%20therapy%20%28ART%29%20for%20all%20people%20with%20HIV%20%28PWH%29%20on%20the%20day%20of%20diagnosis%20when%20possible%2C%20yet%20uncertainty%20exists%20about%20the%20impact%20of%20same-day%20ART%20initiation%20on%20subsequent%20care%20engagement.%20We%20examined%20the%20association%20of%20same-day%20ART%20initiation%20with%20loss%20to%20follow-up%20and%20viral%20suppression%20among%20patients%20in%2011%20sub-Saharan%20African%20countries.%20METHODS%3A%20We%20included%20ART-naive%20adult%20PWH%20from%20sites%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%20who%20enrolled%20in%20care%20after%20Treat-All%20implementation%20and%20prior%20to%20January%202019.%20We%20used%20multivariable%20Cox%20regression%20to%20estimate%20the%20association%20between%20same-day%20ART%20initiation%20and%20loss%20to%20follow-up%20and%20Poisson%20regression%20to%20estimate%20the%20association%20between%20same-day%20ART%20initiation%20and%206-month%20viral%20suppression.%20RESULTS%3A%20Among%2029%20017%20patients%20from%2063%20sites%2C%2018%20584%20%2864.0%25%29%20initiated%20ART%20on%20the%20day%20of%20enrollment.%20Same-day%20ART%20initiation%20was%20less%20likely%20among%20those%20with%20advanced%20HIV%20disease%20versus%20early-stage%20disease.%20Loss%20to%20follow-up%20was%20significantly%20lower%20among%20those%20initiating%20ART%20%26gt%3B%5C%2F%3D1%20day%20of%20enrollment%2C%20compared%20with%20same-day%20ART%20initiators%20%2820.6%25%20vs%2027.7%25%3B%20adjusted%20hazard%20ratio%3A%20.66%3B%2095%25%20CI%20.57-.76%29.%20No%20difference%20in%20viral%20suppression%20was%20observed%20by%20time%20to%20ART%20initiation%20%28adjusted%20rate%20ratio%3A%201.00%3B%2095%25%20CI%3A%20.98-1.02%29.%20CONCLUSIONS%3A%20Patients%20initiating%20ART%20on%20the%20day%20of%20enrollment%20were%20more%20frequently%20lost%20to%20follow-up%20than%20those%20initiating%20later%20but%20were%20equally%20likely%20to%20be%20virally%20suppressed.%20Our%20findings%20support%20recent%20World%20Health%20Organization%20recommendations%20for%20providing%20tailored%20counseling%20and%20support%20to%20patients%20who%20accept%20an%20offer%20of%20same-day%20ART.%22%2C%22date%22%3A%22Jan%206%202023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1093%5C%2Fcid%5C%2Fciac759%22%2C%22ISSN%22%3A%221537-6591%20%28Electronic%29%201058-4838%20%28Print%29%201058-4838%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A10%3A50Z%22%7D%7D%2C%7B%22key%22%3A%226YLLHW7Q%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A16%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaruri%2C%20F.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWester%2C%20C.%20W.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusick%2C%20B.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFreeman%2C%20A.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Design%20and%20implementation%20of%20a%20global%20site%20assessment%20survey%20among%20HIV%20clinics%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20research%20consortium.%20%26lt%3Bi%26gt%3BPLoS%20One%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B18%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e0268167.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0268167%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0268167%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Design%20and%20implementation%20of%20a%20global%20site%20assessment%20survey%20among%20HIV%20clinics%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20research%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%22%2C%22lastName%22%3A%22Maruri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20W.%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Hossmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Christ%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Kimmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Humphrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L.%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20E.%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%20E.%22%2C%22lastName%22%3A%22Golub%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Nash%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aids%20consortium%22%2C%22lastName%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Timely%20descriptions%20of%20HIV%20service%20characteristics%20and%20their%20evolution%20over%20time%20across%20diverse%20settings%20are%20important%20for%20monitoring%20the%20scale-up%20of%20evidence-based%20program%20strategies%2C%20understanding%20the%20implementation%20landscape%2C%20and%20examining%20service%20delivery%20factors%20that%20influence%20HIV%20care%20outcomes.%20METHODS%3A%20The%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium%20undertakes%20periodic%20cross-sectional%20surveys%20on%20service%20availability%20and%20care%20at%20participating%20HIV%20treatment%20sites%20to%20characterize%20trends%20and%20inform%20the%20scientific%20agenda%20for%20HIV%20care%20and%20implementation%20science%20communities.%20IeDEA%26%23039%3Bs%202020%20general%20site%20assessment%20survey%20was%20developed%20through%20a%20consultative%2C%2018-month%20process%20that%20engaged%20diverse%20researchers%20in%20identifying%20content%20from%20previous%20surveys%20that%20should%20be%20retained%20for%20longitudinal%20analyses%20and%20in%20developing%20expanded%20and%20new%20content%20to%20address%20gaps%20in%20the%20literature.%20An%20iterative%20review%20process%20was%20undertaken%20to%20standardize%20the%20format%20of%20new%20survey%20questions%20and%20align%20them%20with%20best%20practices%20in%20survey%20design%20and%20measurement%20and%20lessons%20learned%20through%20prior%20IeDEA%20site%20assessment%20surveys.%20RESULTS%3A%20The%20survey%20questionnaire%20developed%20through%20this%20process%20included%20eight%20content%20domains%20covered%20in%20prior%20surveys%20%28patient%20population%2C%20staffing%20and%20community%20linkages%2C%20HIV%20testing%20and%20diagnosis%2C%20new%20patient%20care%2C%20treatment%20monitoring%20and%20retention%2C%20routine%20HIV%20care%20and%20screening%2C%20pharmacy%2C%20record-keeping%20and%20patient%20tracing%29%2C%20along%20with%20expanded%20content%20related%20to%20antiretroviral%20therapy%20%28differentiated%20service%20delivery%20and%20roll-out%20of%20dolutegravir-based%20regimens%29%3B%20mental%20health%20and%20substance%20use%20disorders%3B%20care%20for%20pregnant%5C%2Fpostpartum%20women%20and%20HIV-exposed%20infants%3B%20tuberculosis%20preventive%20therapy%3B%20and%20pediatric%5C%2Fadolescent%20tuberculosis%20care%3B%20and%20new%20content%20related%20to%20Kaposi%26%23039%3Bs%20sarcoma%20diagnostics%2C%20the%20impact%20of%20COVID-19%20on%20service%20delivery%2C%20and%20structural%20barriers%20to%20HIV%20care.%20The%20survey%20was%20distributed%20to%20238%20HIV%20treatment%20sites%20in%20late%202020%2C%20with%20a%2095%25%20response%20rate.%20CONCLUSION%3A%20IeDEA%26%23039%3Bs%20approach%20for%20site%20survey%20development%20has%20broad%20relevance%20for%20HIV%20research%20networks%20and%20other%20priority%20health%20conditions.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0268167%22%2C%22ISSN%22%3A%221932-6203%20%28Electronic%29%201932-6203%20%28Linking%29%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-03-20T13%3A19%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22URS9BIA7%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Humphrey%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHumphrey%2C%20John%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNagel%2C%20Elizabeth%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCarlucci%2C%20James%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKinikar%2C%20Aarti%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Integration%20of%20HIV%20care%20into%20maternal%20and%20child%20health%20services%20in%20the%20global%20IeDEA%20consortium.%20%26lt%3Bi%26gt%3BFrontiers%20in%20Global%20Women%26%23x2019%3Bs%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%201066297.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffgwh.2023.1066297%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffgwh.2023.1066297%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Integration%20of%20HIV%20care%20into%20maternal%20and%20child%20health%20services%20in%20the%20global%20IeDEA%20consortium%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Humphrey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Nagel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20G.%22%2C%22lastName%22%3A%22Carlucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarti%22%2C%22lastName%22%3A%22Kinikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dwight%20E.%22%2C%22lastName%22%3A%22Yin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Tulio%20Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safari%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tulathip%22%2C%22lastName%22%3A%22Suwanlerk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Athanase%22%2C%22lastName%22%3A%22Munyaneza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rena%20C.%22%2C%22lastName%22%3A%22Patel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Abuogi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%5D%2C%22abstractNote%22%3A%22The%20WHO%20recommends%20the%20integration%20of%20routine%20HIV%20services%20within%20maternal%20and%20child%20health%20%28MCH%29%20services%20to%20reduce%20the%20fragmentation%20of%20and%20to%20promote%20retention%20in%20care%20for%20pregnant%20and%20postpartum%20women%20living%20with%20HIV%20%28WWH%29%20and%20their%20infants%20and%20children%20exposed%20to%20HIV%20%28ICEH%29.%20During%202020-2021%2C%20we%20surveyed%20202%20HIV%20treatment%20sites%20across%2040%20low-%20and%20middle-income%20countries%20within%20the%20global%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20consortium.%20We%20determined%20the%20proportion%20of%20sites%20providing%20HIV%20services%20integrated%20within%20MCH%20clinics%2C%20defined%20as%20full%20%5BHIV%20care%20and%20antiretroviral%20treatment%20%28ART%29%20initiation%20in%20MCH%20clinic%5D%2C%20partial%20%28HIV%20care%20or%20ART%20initiation%20in%20MCH%20clinic%29%2C%20or%20no%20integration.%20Among%20sites%20serving%20pregnant%20WWH%2C%2054%25%20were%20fully%20and%2021%25%20partially%20integrated%2C%20with%20the%20highest%20proportions%20of%20fully%20integrated%20sites%20in%20Southern%20Africa%20%2880%25%29%20and%20East%20Africa%20%2876%25%29%20compared%20to%2014%25-40%25%20in%20other%20regions%20%28i.e.%2C%20Asia-Pacific%3B%20the%20Caribbean%2C%20Central%20and%20South%20America%20Network%20for%20HIV%20Epidemiology%3B%20Central%20Africa%3B%20West%20Africa%29.%20Among%20sites%20serving%20postpartum%20WWH%2C%2051%25%20were%20fully%20and%2010%25%20partially%20integrated%2C%20with%20a%20similar%20regional%20integration%20pattern%20to%20sites%20serving%20pregnant%20WWH.%20Among%20sites%20serving%20ICEH%2C%2056%25%20were%20fully%20and%209%25%20were%20partially%20integrated%2C%20with%20the%20highest%20proportions%20of%20fully%20integrated%20sites%20in%20East%20Africa%20%2876%25%29%2C%20West%20Africa%20%2858%25%29%20and%20Southern%20Africa%20%2854%25%29%20compared%20to%20%5Cu226433%25%20in%20the%20other%20regions.%20Integration%20was%20heterogenous%20across%20IeDEA%20regions%20and%20most%20prevalent%20in%20East%20and%20Southern%20Africa.%20More%20research%20is%20needed%20to%20understand%20this%20heterogeneity%20and%20the%20impacts%20of%20integration%20on%20MCH%20outcomes%20globally.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3389%5C%2Ffgwh.2023.1066297%22%2C%22ISSN%22%3A%222673-5059%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222023-12-01T11%3A00%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22KJCNL3QA%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matzopoulos%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMatzopoulos%2C%20Richard%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPrinsloo%2C%20Megan%20R.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMhlongo%2C%20Shibe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMarineau%2C%20Lea%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BCornell%2C%20Morna%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20South%20Africa%26%23x2019%3Bs%20male%20homicide%20epidemic%20hiding%20in%20plain%20sight%3A%20Exploring%20sex%20differences%20and%20patterns%20in%20homicide%20risk%20in%20a%20retrospective%20descriptive%20study%20of%20postmortem%20investigations.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%20%2811%29%2C%20S.%20e0002595.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002595%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0002595%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22South%20Africa%27s%20male%20homicide%20epidemic%20hiding%20in%20plain%20sight%3A%20Exploring%20sex%20differences%20and%20patterns%20in%20homicide%20risk%20in%20a%20retrospective%20descriptive%20study%20of%20postmortem%20investigations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Matzopoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Megan%20R.%22%2C%22lastName%22%3A%22Prinsloo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shibe%22%2C%22lastName%22%3A%22Mhlongo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Marineau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brett%22%2C%22lastName%22%3A%22Bowman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thakadu%20A.%22%2C%22lastName%22%3A%22Mamashela%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nomonde%22%2C%22lastName%22%3A%22Gwebushe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asiphe%22%2C%22lastName%22%3A%22Ketelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorna%20J.%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Dekel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carl%22%2C%22lastName%22%3A%22Lombard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Jewkes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naeemah%22%2C%22lastName%22%3A%22Abrahams%22%7D%5D%2C%22abstractNote%22%3A%22South%20Africa%20has%20an%20overall%20homicide%20rate%20six%20times%20the%20global%20average.%20Males%20are%20predominantly%20the%20victims%20and%20perpetrators%2C%20but%20little%20is%20known%20about%20the%20male%20victims.%20For%20the%20country%26%23039%3Bs%20first%20ever%20study%20on%20male%20homicide%20we%20compared%202017%20male%20and%20female%20victim%20profiles%20for%20selected%20covariates%2C%20against%20global%20average%20and%20previous%20estimates%20for%202009.%20We%20conducted%20a%20retrospective%20descriptive%20study%20of%20routine%20data%20collected%20through%20postmortem%20investigations%2C%20calculating%20age-standardised%20mortality%20rates%20for%20manner%20of%20death%20by%20age%2C%20sex%20and%20province%20and%20male-to-female%20incidence%20rate%20ratios%20with%2095%25%20confidence%20intervals.%20We%20then%20used%20generalised%20linear%20models%20and%20linear%20regression%20models%20to%20assess%20the%20association%20between%20sex%20and%20victim%20characteristics%20including%20age%20and%20mechanism%20of%20injury%20%28guns%2C%20sharp%20and%20blunt%20force%29%20within%20and%20between%20years.%2087%25%20of%2019%2C477%20homicides%20in%202017%20were%20males%2C%20equating%20to%20seven%20male%20deaths%20for%20every%20female%2C%20with%20sharp%20force%20and%20firearm%20discharge%20being%20the%20most%20common%20cause%20of%20death.%20Rates%20were%20higher%20among%20males%20than%20females%20at%20all%20ages%2C%20and%20up%20to%20eight%20times%20higher%20for%20the%20age%20group%2015-44%20years.%20Provincial%20rates%20varied%20overall%20and%20by%20sex%2C%20with%20the%20highest%20comparative%20risk%20for%20men%20vs.%20women%20in%20the%20Western%20Cape%20Province%20%2811.4%20males%20for%20every%201%20female%29.%20Male%20homicides%20peaked%20during%20December%20and%20were%20highest%20during%20weekends%2C%20underscoring%20the%20prominent%20role%20of%20alcohol%20as%20a%20risk%20factor.%20There%20is%20a%20massive%2C%20disproportionate%20and%20enduring%20homicide%20risk%20among%20South%20African%20men%20which%20highlights%20their%20relative%20neglect%20in%20the%20country%26%23039%3Bs%20prevention%20and%20policy%20responses.%20Only%20through%20challenging%20the%20normative%20perception%20of%20male%20invulnerability%20do%20we%20begin%20to%20address%20the%20enormous%20burden%20of%20violence%20impacting%20men.%20There%20is%20an%20urgent%20need%20to%20address%20the%20insidious%20effect%20of%20such%20societal%20norms%20alongside%20implementing%20structural%20interventions%20to%20overcome%20the%20root%20causes%20of%20poverty%2C%20inequality%20and%20better%20control%20alcohol%20and%20firearms.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0002595%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222023-12-01T10%3A51%3A04Z%22%7D%7D%2C%7B%22key%22%3A%225M799P4L%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dovel%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDovel%2C%20Kathryn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPaneno%2C%20Rose%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBalakasi%2C%20Kelvin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHubbard%2C%20Julie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaga%26%23xE7%3Bo%2C%20Am%26%23xED%3Blcar%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Health%20care%20workers%26%23x2019%3B%20perceptions%20and%20bias%20toward%20men%20as%20HIV%20clients%20in%20Malawi%20and%20Mozambique%3A%20A%20qualitative%20study.%20%26lt%3Bi%26gt%3BPLOS%20Global%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B3%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%20e0001356.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0001356%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pgph.0001356%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Health%20care%20workers%27%20perceptions%20and%20bias%20toward%20men%20as%20HIV%20clients%20in%20Malawi%20and%20Mozambique%3A%20A%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Dovel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rose%22%2C%22lastName%22%3A%22Paneno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelvin%22%2C%22lastName%22%3A%22Balakasi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Hubbard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%5Cu00edlcar%22%2C%22lastName%22%3A%22Maga%5Cu00e7o%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khumbo%22%2C%22lastName%22%3A%22Phiri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Coates%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%5D%2C%22abstractNote%22%3A%22Men%20are%20underrepresented%20in%20HIV%20services%20throughout%20sub-Saharan%20Africa.%20Little%20is%20known%20about%20health%20care%20worker%20%28HCW%29%20perceptions%20of%20men%20as%20clients%2C%20which%20may%20directly%20affect%20the%20quality%20of%20care%20provided%2C%20and%20HCWs%26%23039%3B%20buy-in%20for%20male-specific%20interventions.%20Focus%20group%20discussions%20%28FGDs%29%20were%20conducted%20in%202016%20with%20HCWs%20from%2015%20facilities%20across%20Malawi%20and%20Mozambique%20and%20were%20originally%20conducted%20to%20evaluate%20barriers%20to%20universal%20treatment%20%28not%20HCW%20bias%29.%20FGDs%20were%20conducted%20in%20local%20languages%2C%20recorded%2C%20translated%20to%20English%2C%20and%20transcribed.%20For%20this%20study%2C%20we%20focused%20on%20HCW%20perceptions%20of%20men%20as%20HIV%20clients%20and%20any%20explicit%20bias%20against%20men%2C%20using%20inductive%20and%20deductive%20coding%20in%20Atlas.ti%20v.8%2C%20and%20analyzed%20using%20constant%20comparison%20methods.%2020%20FGDs%20with%20154%20HCWs%20working%20in%20HIV%20treatment%20clinics%20were%20included.%20Median%20age%20was%2030%20years%2C%2059%25%20were%20female%2C%20and%2043%25%20were%20providers%20versus%20support%20staff.%20HCWs%20held%20strong%20explicit%20bias%20against%20men%20as%20clients.%20Most%20HCWs%20believed%20men%20could%20easily%20navigate%20HIV%20services%20due%20to%20their%20elevated%20position%20within%20society%2C%20regardless%20of%20facility-level%20barriers%20faced.%20Men%20were%20described%20in%20pejorative%20terms%20as%20ill-informed%20and%20difficult%20clients%20who%20were%20absent%20from%20health%20systems.%20Men%20were%20largely%20seen%20as%20%26quot%3Bbad%20clients%26quot%3B%20due%20to%20assumptions%20about%20men%26%23039%3Bs%20%26%23039%3Bselfish%26%23039%3B%20and%20%26%23039%3Bprideful%26%23039%3B%20nature%2C%20resulting%20in%20little%20HCW%20sympathy%20for%20men%26%23039%3Bs%20poor%20use%20of%20care.%20Our%20study%20highlights%20a%20strong%20explicit%20bias%20against%20men%20as%20HIV%20clients%2C%20even%20when%20gender%20and%20bias%20were%20not%20the%20focus%20of%20data%20collection.%20As%20a%20result%2C%20HCWs%20may%20have%20little%20motivation%20to%20implement%20male-specific%20interventions%20or%20improve%20provider-patient%20interactions%20with%20men.%20Framing%20men%20as%20problematic%20places%20undue%20responsibility%20on%20individual%20men%20while%20minimizing%20institutional%20barriers%20that%20uniquely%20affect%20them.%20Bias%20in%20local%2C%20national%2C%20and%20global%20discourses%20about%20men%20must%20be%20immediately%20addressed.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pgph.0001356%22%2C%22ISSN%22%3A%222767-3375%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A53%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22VXJDKC43%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hermans%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHermans%2C%20Lucas%20E.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBooysen%2C%20Petro%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBoloko%2C%20Linda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAdriaanse%2C%20Marguerite%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Wet%2C%20Timothy%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282023%29.%20Changing%20character%20and%20waning%20impact%20of%20COVID-19%20at%20a%20tertiary%20centre%20in%20Cape%20Town%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BSouthern%20African%20Journal%20of%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20550.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4102%5C%2Fsajid.v38i1.550%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4102%5C%2Fsajid.v38i1.550%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Changing%20character%20and%20waning%20impact%20of%20COVID-19%20at%20a%20tertiary%20centre%20in%20Cape%20Town%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucas%20E.%22%2C%22lastName%22%3A%22Hermans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petro%22%2C%22lastName%22%3A%22Booysen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Boloko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marguerite%22%2C%22lastName%22%3A%22Adriaanse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timothy%20J.%22%2C%22lastName%22%3A%22de%20Wet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%20R.%22%2C%22lastName%22%3A%22Lifson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naweed%22%2C%22lastName%22%3A%22Wadee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nectarios%22%2C%22lastName%22%3A%22Papavarnavas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gert%22%2C%22lastName%22%3A%22Marais%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nei-Yuan%22%2C%22lastName%22%3A%22Hsiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael-Jon%22%2C%22lastName%22%3A%22Rosslee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%22%2C%22lastName%22%3A%22Symons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20L.%22%2C%22lastName%22%3A%22Calligaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arash%22%2C%22lastName%22%3A%22Iranzadeh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20J.%22%2C%22lastName%22%3A%22Wilkinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ntobeko%20A.%20B.%22%2C%22lastName%22%3A%22Ntusi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Williamson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graeme%22%2C%22lastName%22%3A%22Meintjes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Wasserman%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20emergence%20of%20genetic%20variants%20of%20SARS-CoV-2%20was%20associated%20with%20changing%20epidemiological%20characteristics%20throughout%20coronavirus%20disease%202019%20%28COVID-19%29%20pandemic%20in%20population-based%20studies.%20Individual-level%20data%20on%20the%20clinical%20characteristics%20of%20infection%20with%20different%20SARS-CoV-2%20variants%20in%20African%20countries%20is%20less%20well%20documented.%5CnOBJECTIVES%3A%20To%20describe%20the%20evolving%20clinical%20differences%20observed%20with%20the%20various%20SARS-CoV-2%20variants%20of%20concern%20and%20compare%20the%20Omicron-driven%20wave%20in%20infections%20to%20the%20previous%20Delta-driven%20wave.%5CnMETHOD%3A%20We%20performed%20a%20retrospective%20observational%20cohort%20study%20among%20patients%20admitted%20to%20a%20South%20African%20referral%20hospital%20with%20COVID-19%20pneumonia.%20Patients%20were%20stratified%20by%20epidemiological%20wave%20period%2C%20and%20in%20a%20subset%2C%20the%20variants%20associated%20with%20each%20wave%20were%20confirmed%20by%20genomic%20sequencing.%20Outcomes%20were%20analysed%20by%20Cox%20proportional%20hazard%20models.%5CnRESULTS%3A%20We%20included%201689%20patients%20were%20included%2C%20representing%20infection%20waves%20driven%20predominantly%20by%20ancestral%2C%20Beta%2C%20Delta%20and%20Omicron%20BA1%5C%2FBA2%20%26amp%3B%20BA4%5C%2FBA5%20variants.%20Crude%2028-day%20mortality%20was%2025.8%25%20%2834%5C%2F133%29%20in%20the%20Omicron%20wave%20period%20versus%2037.1%25%20%28138%5C%2F374%29%20in%20the%20Delta%20wave%20period%20%28hazard%20ratio%20%5BHR%5D%200.68%20%5B95%25%20CI%200.47-1.00%5D%20p%20%3D%200.049%29%3B%20this%20effect%20persisted%20after%20adjustment%20for%20age%2C%20gender%2C%20HIV%20status%20and%20presence%20of%20cardiovascular%20disease%20%28adjusted%20HR%20%5BaHR%5D%200.43%20%5B95%25%20CI%200.28-0.67%5D%20p%20%26lt%3B%200.001%29.%20Hospital-wide%20SARS-CoV-2%20admissions%20and%20deaths%20were%20highest%20during%20the%20Delta%20wave%20period%2C%20with%20a%20decoupling%20of%20SARS-CoV-2%20deaths%20and%20overall%20deaths%20thereafter.%5CnCONCLUSION%3A%20There%20was%20lower%20in-hospital%20mortality%20during%20Omicron-driven%20waves%20compared%20with%20the%20prior%20Delta%20wave%2C%20despite%20patients%20admitted%20during%20the%20Omicron%20wave%20being%20at%20higher%20risk.%5CnCONTRIBUTION%3A%20This%20study%20summarises%20clinical%20characteristics%20associated%20with%20SARS-CoV-2%20variants%20during%20the%20COVID-19%20pandemic%20at%20a%20South%20African%20tertiary%20hospital%2C%20demonstrating%20a%20waning%20impact%20of%20COVID-19%20on%20healthcare%20services%20over%20time%20despite%20epidemic%20waves%20driven%20by%20new%20variants.%20Findings%20suggest%20the%20absence%20of%20increasing%20virulence%20from%20later%20variants%20and%20protection%20from%20population%20and%20individual-level%20immunity.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.4102%5C%2Fsajid.v38i1.550%22%2C%22ISSN%22%3A%222313-1810%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222024-03-18T10%3A51%3A39Z%22%7D%7D%5D%7D
Banholzer, Nicolas; Jent, Philipp; Bittel, Pascal; Zürcher, Kathrin; Furrer, Lavinia et al. (2023). Air cleaners and respiratory infections in schools: A modeling study using epidemiological, environmental, and molecular data. medRxiv: The Preprint Server for Health Sciences, S. 2023.12.29.23300635. http://doi.org/10.1101/2023.12.29.23300635.
Trickey, Adam; Johnson, Leigh F.; Fung, Fai; Bonifacio, Rogerio; Iwuji, Collins et al. (2023). Associations of inter-annual rainfall decreases with subsequent HIV outcomes for persons with HIV on antiretroviral therapy in Southern Africa: a collaborative analysis of cohort studies. BMC Infectious Diseases, 23 (1), S. 889. http://doi.org/10.1186/s12879-023-08902-9.
Skrivankova, Veronika W.; Hossmann, Stefanie; Cornell, Morna; Ballif, Marie; Dupont, Carole et al. (2023). Authorship inequalities in global health research: the IeDEA Southern Africa collaboration. BMJ Global Health, 8 (12), S. e013316. http://doi.org/10.1136/bmjgh-2023-013316.
Ruffieux, Yann; Wettstein, Anja; Maartens, Gary; Folb, Naomi; Mesa-Vieira, Cristina et al. (2023). Life years lost associated with mental illness: A cohort study of beneficiaries of a South African medical insurance scheme. Journal of Affective Disorders, 340, S. 204–212. http://doi.org/10.1016/j.jad.2023.08.013.
Muula, Guy K.; Bosomprah, Samuel; Sinkala, Edford; Nsokolo, Bright; Musonda, Taonga et al. (2023). Hepatitis B viral replication markers and hepatic fibrosis in untreated chronic hepatitis B virus infection with and without HIV coinfection in Zambia. AIDS (London, England), 37 (13), S. 2015–2020. http://doi.org/10.1097/QAD.0000000000003659.
Loosli, Tom; Hossmann, Stefanie; Ingle, Suzanne M.; Okhai, Hajra; Kusejko, Katharina et al. (2023). HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis. The Lancet. HIV, 10 (11), S. e733–e741. http://doi.org/10.1016/S2352-3018(23)00228-X.
Metekoua, Carole; Ruffieux, Yann; Olago, Victor; Dhokotera, Tafadzwa; Egger, Matthias et al. (2023). Decreasing incidence of conjunctival squamous cell carcinoma in people with HIV in South Africa. Journal of the National Cancer Institute, 115 (10), S. 1213–1219. http://doi.org/10.1093/jnci/djad119.
de Beer, Shani T.; Slogrove, Amy L.; Eley, Brian; Ingle, Suzanne M.; Jones, Hayley E. et al. (2023). Change in HIV-related characteristics of children hospitalised with infectious diseases in Western Cape, South Africa, 2008-2021: a time trend analysis. Journal of the International AIDS Society, 26 Suppl 4 (Suppl 4), S. e26151. http://doi.org/10.1002/jia2.26151.
Slogrove, Amy L.; Bovu, Andisiwe; de Beer, Shani; Phelanyane, Florence; Williams, Paige L. et al. (2023). Maternal and birth outcomes in pregnant people with and without HIV in the Western Cape, South Africa: population-based cohort study. AIDS (London, England). http://doi.org/10.1097/QAD.0000000000003728.
Hansford, Harrison J.; Cashin, Aidan G.; Jones, Matthew D.; Swanson, Sonja A.; Islam, Nazrul et al. (2023). Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline. BMJ Open, 13 (9), S. e074626. http://doi.org/10.1136/bmjopen-2023-074626.
Olago, Victor; Nimako, Gideon; Bartels, Lina; Bohlius, Julia; Dhokotera, Tafadzwa et al. (2023). Cancer diagnostic service use in people with HIV in South Africa: a cross-sectional study. medRxiv: The Preprint Server for Health Sciences, S. 2023.09.10.23295338. http://doi.org/10.1101/2023.09.10.23295338.
Hansford, Harrison J.; Cashin, Aidan G.; Jones, Matthew D.; Swanson, Sonja A.; Islam, Nazrul et al. (2023). Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review. JAMA Network Open, 6 (9), S. e2336023. http://doi.org/10.1001/jamanetworkopen.2023.36023.
Zürcher, Kathrin; Abela, Irene A.; Stange, Madlen; Dupont, Carole; Mugglin, Catrina et al. (2023). Alpha Variant Coronavirus Outbreak in a Nursing Home Despite High Vaccination Coverage: Molecular, Epidemiological, and Immunological Studies. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 77 (4), S. 537–546. http://doi.org/10.1093/cid/ciab1005.
Anderegg, Nanina; Schwab, Tiana; Borcard, Loïc; Mugglin, Catrina; Keune-Dübi, Bettina et al. (2023). Population-Based Severe Acute Respiratory Syndrome Coronavirus 2 Whole-Genome Sequencing and Contact Tracing During the Coronavirus Disease 2019 Pandemic in Switzerland. The Journal of Infectious Diseases, 228 (3), S. 251–260. http://doi.org/10.1093/infdis/jiad074.
Global variations in pubertal growth spurts in adolescents living with perinatal HIV (2023). AIDS (London, England), 37 (10), S. 1603–1615. http://doi.org/10.1097/QAD.0000000000003602.
Parcesepe, Angela M.; Stockton, Melissa; Remch, Molly; Wester, C. William; Bernard, Charlotte et al. (2023). Availability of screening and treatment for common mental disorders in HIV clinic settings: data from the global International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium, 2016-2017 and 2020. Journal of the International AIDS Society, 26 (8), S. e26147. http://doi.org/10.1002/jia2.26147.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Manzero, Josphat; Hossmann, Stefanie; Limacher, Andreas et al. (2023). Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial. JAMA Network Open, 6 (7), S. e2323205. http://doi.org/10.1001/jamanetworkopen.2023.23205.
Person, Anna K.; Crabtree-Ramirez, Brenda; Kim, Ahra; Veloso, Valdiléa; Maruri, Fernanda et al. (2023). Cryptococcal Meningitis and Clinical Outcomes in Persons With Human Immunodeficiency Virus: A Global View. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 76 (12), S. 2116–2125. http://doi.org/10.1093/cid/ciad076.
Kubjane, M.; Cornell, M.; Osman, M.; Boulle, A. & Johnson, L. F. (2023). Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019. Sci Rep, 13 (1), S. 9487. http://doi.org/10.1038/s41598-023-36432-6.
Taghavi, Katayoun; Moono, Misinzo; Mwanahamuntu, Mulindi; Roumet, Marie; Limacher, Andreas et al. (2023). Accuracy of screening tests for cervical pre-cancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia. medRxiv : The Preprint Server for Health Sciences, S. 2023.05.31.23290779. http://doi.org/10.1101/2023.05.31.23290779.
Dovel, K. L.; Hariprasad, S.; Hubbard, J.; Cornell, M.; Phiri, K. et al. (2023). Strategies to improve antiretroviral therapy (ART) initiation and early engagement among men in sub-Saharan Africa: A scoping review of interventions in the era of universal treatment. Trop Med Int Health, 28 (6), S. 454–465. http://doi.org/10.1111/tmi.13880.
Haas, A. D.; Lienhard, R.; Didden, C.; Cornell, M.; Folb, N. et al. (2023). Mental Health, ART Adherence, and Viral Suppression Among Adolescents and Adults Living with HIV in South Africa: A Cohort Study. AIDS Behav, 27 (6), S. 1849–1861. http://doi.org/10.1007/s10461-022-03916-x.
Kassanjee, R.; Davies, M. A.; Ngwenya, O.; Osei-Yeboah, R.; Jacobs, T. et al. (2023). COVID-19 among adults living with HIV: correlates of mortality among public sector healthcare users in Western Cape, South Africa. J Int AIDS Soc, 26 (6), S. e26104. http://doi.org/10.1002/jia2.26104.
Cipriani, Andrea; Seedat, Soraya; Milligan, Lea; Salanti, Georgia; Macleod, Malcolm et al. (2023). New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis. BMJ Mental Health, 26 (1), S. e300759. http://doi.org/10.1136/bmjment-2023-300759.
Pretsch, Peyton K.; Spees, Lisa P.; Brewer, Noel T.; Hudgens, Michael G.; Sanusi, Busola et al. (2023). Effect of HPV self-collection kits on cervical cancer screening uptake among under-screened women from low-income US backgrounds (MBMT-3): a phase 3, open-label, randomised controlled trial. The Lancet. Public Health, 8 (6), S. e411–e421. http://doi.org/10.1016/S2468-2667(23)00076-2.
Banholzer, N.; Zurcher, K.; Jent, P.; Bittel, P.; Furrer, L. et al. (2023). SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data. PLoS Med, 20 (5), S. e1004226. http://doi.org/10.1371/journal.pmed.1004226.
Ruffieux, Y.; Muchengeti, M.; Olago, V.; Dhokotera, T.; Bohlius, J. et al. (2023). Age and Cancer Incidence in 5.2 Million People With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study. Clin Infect Dis, 76 (8), S. 1440–1448. http://doi.org/10.1093/cid/ciac925.
Loosli, Tom; Hossmann, Stefanie; Ingle, Suzanne M.; Okhai, Hajra; Kusejko, Katharina et al. (2023). sHIV-1 drug resistance in people on dolutegravir-based ART: Collaborative analysis of cohort studies. medRxiv: The Preprint Server for Health Sciences, S. 2023.04.05.23288183. http://doi.org/10.1101/2023.04.05.23288183.
Patten, G.; Sipambo, N.; Technau, K. G.; Euvrard, J.; Ford, N. et al. (2023). Ongoing High Prevalence of Severe Immune Suppression Among Children in South Africa. J Acquir Immune Defic Syndr, 92 (4), S. 273–280. http://doi.org/10.1097/QAI.0000000000003137.
Zwyer, M.; Rutaihwa, L. K.; Windels, E.; Hella, J.; Menardo, F. et al. (2023). Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. PLoS Pathog, 19 (4), S. e1010893. http://doi.org/10.1371/journal.ppat.1010893.
Vreeman, R. C.; Yiannoutsos, C. T.; Yusoff, N. K. N.; Wester, C. W.; Edmonds, A. et al. (2023). Global HIV prevention, care and treatment services for children: a cross-sectional survey from the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium. BMJ Open, 13 (3), S. e069399. http://doi.org/10.1136/bmjopen-2022-069399.
Anderson, K.; Iyun, V.; Eley, B. S.; Rabie, H.; Ferreira, T. et al. (2023). Hospitalization among infants who initiate antiretroviral therapy before 3 months of age. AIDS, 37 (3), S. 435–445. http://doi.org/10.1097/QAD.0000000000003422.
Patten, G. E.; Euvrard, J.; Anderegg, N.; Boulle, A.; Arendse, K. D. et al. (2023). Advanced HIV disease and engagement in care among patients on antiretroviral therapy in South Africa: results from a multi-state model. AIDS, 37 (3), S. 513–522. http://doi.org/10.1097/QAD.0000000000003442.
Ruffieux, Yann; Wettstein, Anja; Maartens, Gary; Folb, Naomi; Vieira, Cristina Mesa et al. (2023). Life-years lost associated with mental illness: a cohort study of beneficiaries of a South African medical insurance scheme. medRxiv : The Preprint Server for Health Sciences, S. 2023.01.19.23284778. http://doi.org/10.1101/2023.01.19.23284778.
de Waal, Renee; Rabie, Helena; Technau, Karl-Gunter; Eley, Brian; Sipambo, Nosisa et al. (2023). Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts. Antiviral Therapy, 28 (2), S. 13596535231168480. http://doi.org/10.1177/13596535231168480.
Haas, Andreas D.; Kunzekwenyika, Cordelia; Manzero, Josphat; Hossmann, Stefanie; Limacher, Andreas et al. (2023). Effect of the Friendship Bench intervention on antiretroviral therapy outcomes and mental health symptoms in rural Zimbabwe: A cluster randomized trial. medRxiv: The Preprint Server for Health Sciences, S. 2023.01.21.23284784. http://doi.org/10.1101/2023.01.21.23284784.
Ross, J.; Brazier, E.; Fatti, G.; Jaquet, A.; Tanon, A. et al. (2023). Same-Day Antiretroviral Therapy Initiation as a Predictor of Loss to Follow-up and Viral Suppression Among People With Human Immunodeficiency Virus in Sub-Saharan Africa. Clin Infect Dis, 76 (1), S. 39–47. http://doi.org/10.1093/cid/ciac759.
Brazier, E.; Maruri, F.; Wester, C. W.; Musick, B.; Freeman, A. et al. (2023). Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. PLoS One, 18 (3), S. e0268167. http://doi.org/10.1371/journal.pone.0268167.
Humphrey, John; Nagel, Elizabeth; Carlucci, James G.; Edmonds, Andrew; Kinikar, Aarti et al. (2023). Integration of HIV care into maternal and child health services in the global IeDEA consortium. Frontiers in Global Women’s Health, 4, S. 1066297. http://doi.org/10.3389/fgwh.2023.1066297.
Matzopoulos, Richard; Prinsloo, Megan R.; Mhlongo, Shibe; Marineau, Lea; Cornell, Morna et al. (2023). South Africa’s male homicide epidemic hiding in plain sight: Exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations. PLOS Global Public Health, 3 (11), S. e0002595. http://doi.org/10.1371/journal.pgph.0002595.
Dovel, Kathryn; Paneno, Rose; Balakasi, Kelvin; Hubbard, Julie; Magaço, Amílcar et al. (2023). Health care workers’ perceptions and bias toward men as HIV clients in Malawi and Mozambique: A qualitative study. PLOS Global Public Health, 3 (10), S. e0001356. http://doi.org/10.1371/journal.pgph.0001356.
Hermans, Lucas E.; Booysen, Petro; Boloko, Linda; Adriaanse, Marguerite; de Wet, Timothy J. et al. (2023). Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa. Southern African Journal of Infectious Diseases, 38 (1), S. 550. http://doi.org/10.4102/sajid.v38i1.550.