Journal Articles Published In 2025

2775998 TCMBXKKM 2025 1 padagogische-hochschule-bern-institut-vorschulstufe-und-primarstufe 50 date desc year 4794 https://www.iedea-sa.org/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22FQJAXEFL%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-27%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMureithi%2C%20Fiona%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanda%2C%20Esau%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBittel%2C%20Pascal%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Reducing%20spatial%20clustering%20to%20prevent%20tuberculosis%20transmission%20in%20a%20busy%20Zambian%20hospital%3A%20a%20modelling%20study%20based%20on%20person%20movements%2C%20environmental%20and%20clinical%20data.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.12.24.25342956.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.24.25342956%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.24.25342956%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reducing%20spatial%20clustering%20to%20prevent%20tuberculosis%20transmission%20in%20a%20busy%20Zambian%20hospital%3A%20a%20modelling%20study%20based%20on%20person%20movements%2C%20environmental%20and%20clinical%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fiona%22%2C%22lastName%22%3A%22Mureithi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esau%22%2C%22lastName%22%3A%22Banda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Bittel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavinia%22%2C%22lastName%22%3A%22Furrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Kronthaler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Hospitals%20in%20high-burden%20tuberculosis%20%28TB%29%20settings%20are%20important%20sites%20of%20Mycobacterium%20tuberculosis%20%28Mtb%29%20transmission%2C%20yet%20the%20impact%20of%20infection%20prevention%20and%20control%20%28IPC%29%20measures%20targeting%20crowding%20is%20poorly%20understood.%20We%20assessed%20the%20effects%20of%20simple%20interventions%20to%20reduce%20spatial%20clustering%20and%20airborne%20transmission%20in%20a%20Zambian%20hospital.%5CnMETHODS%20AND%20FINDINGS%3A%20From%20June%20to%20August%202024%2C%20we%20prospectively%20collected%20clinical%20data%20on%20presumptive%20%28symptom-based%20screening%29%20and%20confirmed%20%28Xpert-positive%2C%20chest%20X-ray%29%20TB%20patients%2C%20indoor%20CO2%20levels%2C%20bioaerosol%20samples%2C%20and%20continuous%20person%20movements%20%28optical%20sensors%29%20in%20the%20hospital%26%23039%3Bs%20main%20waiting%20hall.%20Airborne%20Mtb%20DNA%20was%20detected%20using%20hourly%20cyclonic%20bioaerosol%20sampling.%20Using%20a%20spatiotemporal%20Wells-Riley%20model%20integrating%20ventilation%2C%20proximity%20between%20visitors%2C%20and%20movement%20patterns%2C%20we%20estimated%20Mtb%20transmission%20risk%20under%20routine%20conditions%20and%20during%20two%20IPC%20interventions%3A%20%281%29%20an%20optimised%20waiting-area%20layout%20with%20physical%20distancing%20measures%3B%20and%20%282%29%20an%20added%20one-way%20patient%20flow%20system.During%2052%20days%2C%20668%20presumptive%20and%2045%20confirmed%20TB%20patients%20visited%20the%20hospital%2C%20and%20671%20840%20person%20movements%20were%20recorded.%20Despite%20excellent%20natural%20ventilation%20%28median%20CO2%20455%20ppm%3B%208.0%20air%20changes%20per%20hour%29%2C%20airborne%20Mtb%20was%20detected%20on%20six%20days.%20The%20first%20intervention%20reduced%20spatial%20clustering%20by%20an%20estimated%2024%25%20%2895%25%20credible%20interval%20%5BCrI%5D%2013-32%29%20and%20the%20second%20by%2013%25%20%2895%25%20CrI%201-23%29.%20The%20interventions%20lowered%20Mtb%20transmission%20risk%20by%20an%20estimated%2039%25%20%2895%25%20CrI%2029-48%29%20and%2021%25%20%2895%25%20CrI%209-32%29%2C%20respectively.%20Over%20the%20four%20weeks%20of%20implementation%2C%20they%20collectively%20averted%20an%20estimated%2016%20%2895%25%20CrI%208-26%29%20infections.%5CnCONCLUSIONS%3A%20In%20this%20high-burden%2C%20well-ventilated%20hospital%2C%20short-range%20exposure%20remained%20a%20driver%20of%20airborne%20Mtb%20transmission.%20Simple%2C%20low-cost%20operational%20changes%20to%20reduce%20clustering%20substantially%20decreased%20proximity-driven%20transmission%20risk.%20Integrating%20proximity-focused%20strategies%20can%20meaningfully%20strengthen%20IPC%20in%20resource-limited%20healthcare%20settings.%22%2C%22date%22%3A%222025-12-27%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.64898%5C%2F2025.12.24.25342956%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A33%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22RDYW2XJC%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22de%20Beer%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bde%20Beer%2C%20Shani%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BIngle%2C%20Suzanne%20M.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSlogrove%2C%20Amy%20L.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Infectious-cause%20hospitalisation%20in%20a%20province-wide%20cohort%20of%20children%20with%20antenatal%20HIV%20exposure%20compared%20to%20children%20without%20HIV%20exposure.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004423%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004423%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infectious-cause%20hospitalisation%20in%20a%20province-wide%20cohort%20of%20children%20with%20antenatal%20HIV%20exposure%20compared%20to%20children%20without%20HIV%20exposure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shani%20T.%22%2C%22lastName%22%3A%22de%20Beer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suzanne%20M.%22%2C%22lastName%22%3A%22Ingle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20L.%22%2C%22lastName%22%3A%22Slogrove%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hayley%20E.%22%2C%22lastName%22%3A%22Jones%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20We%20described%20and%20compared%20infectious-cause%20hospitalisation%20outcomes%20among%20children%20born%20without%20HIV%20in%20the%20Western%20Cape%20%28WC%29%2C%20South%20Africa%2C%20during%20the%20WHO%20Option%20B%2B%20%282013-2015%29%20and%20universal%20ART%20%282016-2018%29%20eras%20by%20exposure%20to%20maternal%20HIV%20and%20ART.%5CnDESIGN%3A%20Retrospective%20cohort.%5CnMETHODS%3A%20Using%20data%20from%20the%20WC%20Provincial%20Health%20Data%20Centre%2C%20we%20described%20rates%2C%20causes%20and%20risk%20factors%20of%20infectious-cause%20hospitalisations%2C%20up%20to%20age%203%5Cu200ayears%2C%20among%20children%20born%20at%20a%20public%20WC%20health%20facility.%20We%20compared%20rates%20of%20and%20risk%20factors%20for%20admission%2C%20in%20children%20exposed%20to%20maternal%20HIV%20and%20uninfected%20%28HEU%29%20and%20children%20HIV%20unexposed%20and%20uninfected%20%28HUU%29%2C%20in%20the%20neonatal%2C%20post-neonatal%20%28age%20%26gt%3B28%5Cu200adays%20to%20%5Cu226412%5Cu200amonths%29%2C%20and%20age%20%26gt%3B12-36%5Cu200amonth%20periods%20using%20mixed-effects%20Poisson%20regression.%20Regression%20models%20were%20adjusted%20for%20maternal%20age%20and%20suburb%20of%20residence.%5CnRESULTS%3A%20We%20included%20398%2C334%20mother-child%20pairs%2C%2017.2%25%20children%20HEU%20and%2082.8%25%20HUU.%20Infectious-cause%20hospitalisation%2C%20between%20birth%20and%20age%203%5Cu200ayears%2C%20occurred%20in%2011.5%25%20vs.%2010.9%25%20of%20children%20HEU%20and%20HUU%20respectively.%20Children%20HEU%20experienced%20higher%20rates%20of%20hospitalisation%20than%20children%20HUU%2C%20irrespective%20of%20maternal%20ART%20history%2C%20during%20the%20neonatal%20period%20%28adjusted%20incidence%20rate%20ratios%2C%20aIRRs%3A%201.34-1.66%29%20and%20post-neonatal%20period%20%28aIRRs%3A%201.13-1.42%29%2C%20but%20not%20during%20the%20%26gt%3B12-36%5Cu200amonth%20period.%20Among%20children%20HEU%2C%20maternal%20VL%20%5Cu22651000%5C%2FmL%20vs.%20%26lt%3B1000%5C%2FmL%20during%20pregnancy%20was%20associated%20with%20higher%20admission%20rates%20during%20the%20post-neonatal%20period%20%28aIRR%5Cu200a%3D%5Cu200a1.15%3B%2095%25%20CI%3A1.06-1.25%29.%5CnCONCLUSIONS%3A%20Irrespective%20of%20timing%20of%20maternal%20ART%20start%2C%20children%20HEU%20vs.%20HUU%20had%20higher%20rates%20of%20infectious-cause%20hospitalisation%20during%20the%20first%20year%20of%20life%2C%20but%20not%20thereafter.%22%2C%22date%22%3A%222025-12-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004423%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-5571%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A37%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22TD6C852E%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pan%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPan%2C%20Zhongzhe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRoss%2C%20Jeremy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTempleton%2C%20David%20J.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Limited%20user%20fees%20for%20adult%20HIV%20diagnosis%20and%20routine%20laboratory%20monitoring%20in%20the%20global%20IeDEA%20consortium%3A%20analysis%20in%2042%20countries.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.12.05.25341715.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.05.25341715%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.64898%5C%2F2025.12.05.25341715%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Limited%20user%20fees%20for%20adult%20HIV%20diagnosis%20and%20routine%20laboratory%20monitoring%20in%20the%20global%20IeDEA%20consortium%3A%20analysis%20in%2042%20countries%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhongzhe%22%2C%22lastName%22%3A%22Pan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeremy%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Templeton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sanjay%22%2C%22lastName%22%3A%22Pujari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lauren%20C.%22%2C%22lastName%22%3A%22Zalla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronald%20M.%22%2C%22lastName%22%3A%22Galiwango%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Carriquiry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Chenal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Romanee%22%2C%22lastName%22%3A%22Chaiwarith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raynell%22%2C%22lastName%22%3A%22Lang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helen%22%2C%22lastName%22%3A%22Byakwaga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Cesar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Freeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%20O.%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%20Wagner%22%2C%22lastName%22%3A%22Cordoso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ephrem%22%2C%22lastName%22%3A%22Mensah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathleen%22%2C%22lastName%22%3A%22McGinnis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ethel%22%2C%22lastName%22%3A%22Rambiki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Armel%22%2C%22lastName%22%3A%22Poda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22April%20D.%22%2C%22lastName%22%3A%22Kimmel%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20While%20HIV%20services%20have%20scaled%20up%20dramatically%20under%20universal%20treatment%20recommendations%2C%20availability%20of%20routine%20laboratory%20services%20for%20HIV%20diagnosis%20and%20management%2C%20and%20the%20extent%20to%20which%20user%20fees%20are%20charged%20for%20these%20services%2C%20are%20not%20well%20documented.%20We%20described%20site-level%20availability%20and%20user%20fees%20for%20adult%20HIV%20laboratory%20testing%20among%20238%20sites%20in%2042%20countries%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20global%20consortium%2C%20and%20contextualized%20practices%20by%20site-%20and%20country-level%20characteristics%2C%20including%20country%20income%20level%20and%20receipt%20of%20Global%20Fund%20or%20PEPFAR%20support.%5CnMETHODS%3A%20Availability%20of%20HIV-related%20laboratory%20services%20and%20charging%20of%20user%20fees%2C%20were%20examined%20via%20an%20IeDEA%20site%20assessment%20survey%20conducted%20September%202020-March%202021%2C%20with%20responses%20reflecting%20practices%20in%202019.%20Laboratory%20services%20examined%20included%3A%20HIV-1%5C%2FHIV-2%20antigen%5C%2Fantibody%20immunoassay%20test%20%28HIV-1%5C%2F2%20Ag%5C%2FAb%29%2C%20HIV-1%20p24%20antigen%20test%20%28p24%29%2C%20supplemental%20HIV-1%5C%2FHIV-2%20antibody%20differentiation%20immunoassay%20%28HIV-1%5C%2F2%20Ab%20suppl%29%2C%20quantitative%20PCR%20for%20HIV%20viral%20load%20%28VL%29%2C%20HIV-1%20genotypic%20drug%20resistance%20testing%20%28genotyping%29%2C%20and%20CD4%20count%20testing%20%28CD4%29.%20Availability%20was%20defined%20as%20provided%20on-site%20in%20the%20HIV%20clinic%20or%20within%20the%20same%20health%20facility.%20User%20fees%20were%20fees%20other%20than%20insurance%20co-pays%20paid%20for%20a%20given%20test%2C%20conditional%20on%20their%20on-site%20availability.%20We%20reported%20frequencies%20and%20percentages%20of%20site-level%20availability%20and%20user%20fees%2C%20overall%20and%20by%20site-%20and%20country-level%20characteristics.%5CnRESULTS%3A%20Most%20sites%20%2888%25%29%20reported%20HIV-1%5C%2FHIV-2%20Ag%5C%2FAb%20availability%20on-site%2C%20while%20fewer%20than%20half%20of%20sites%20reported%20having%20p24%20and%20HIV-1%5C%2F2%20Ab%20suppl%20available.%20Approximately%20half%20of%20sites%20reported%20VL%20and%20CD4%20testing%20availability%2C%20while%20less%20than%20one-third%20of%20sites%20%2828%25%29%20reported%20genotyping%20availability.%20The%20percentage%20of%20sites%20reporting%20user%20fees%20ranged%20from%206.5%25%20%28HIV-1%5C%2F2%20Ag%5C%2FAb%29%20to%2010.5%25%20%28CD4%29.%20A%20higher%20percentage%20of%20sites%20reporting%20user%20fees%20were%20from%20upper-middle%20income%20countries%2C%20countries%20receiving%20any%20Global%20Fund%20or%20any%20PEPFAR%20country%20support%2C%20and%20the%20Asia-Pacific%20region.%5CnCONCLUSIONS%3A%20While%20most%20HIV%20care%20sites%20participating%20in%20IeDEA%20did%20not%20charge%20user%20fees%20for%20HIV-related%20laboratory%20tests%20in%202019%2C%20on-site%20availability%20of%20such%20tests%20was%20limited.%20Continued%20action%20to%20identify%20and%20address%20constraints%20in%20the%20routine%20provision%20of%20these%20laboratory%20services%20is%20critical%20for%20appropriate%20management%20of%20HIV.%22%2C%22date%22%3A%222025-12-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.64898%5C%2F2025.12.05.25341715%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222026-01-15T09%3A49%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22FE4NEL89%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Han%20et%20al.%22%2C%22parsedDate%22%3A%222025-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHan%2C%20Nuri%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLoosli%2C%20Tom%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderegg%2C%20Nanina%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHauser%2C%20Anthony%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJosi%2C%20Johannes%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20effect%20of%20long-acting%20cabotegravir%20and%20rilpivirine%20treatment%20on%20drug%20resistance%20in%20South%20Africa%3A%20a%20modelling%20study.%20%26lt%3Bi%26gt%3BThe%20Lancet.%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%20e2133%26%23x2013%3Be2143.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2825%2900350-X%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2214-109X%2825%2900350-X%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20long-acting%20cabotegravir%20and%20rilpivirine%20treatment%20on%20drug%20resistance%20in%20South%20Africa%3A%20a%20modelling%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nuri%22%2C%22lastName%22%3A%22Han%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tom%22%2C%22lastName%22%3A%22Loosli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Hauser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Josi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%20F.%22%2C%22lastName%22%3A%22Johnson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Lessells%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huldrych%20F.%22%2C%22lastName%22%3A%22G%5Cu00fcnthard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roger%20D.%22%2C%22lastName%22%3A%22Kouyos%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Long-acting%20injectable%20cabotegravir%20and%20rilpivirine%20%28LAI%20cabotegravir%20and%20rilpivirine%29%20is%20recommended%20as%20maintenance%20therapy%20for%20people%20living%20with%20HIV%20who%20achieved%20viral%20suppression%20on%20oral%20antiretroviral%20therapy%20%28ART%29.%20However%2C%20its%20effect%20on%20drug%20resistance%20evolution%20in%20resource-limited%20settings%20remains%20uncertain.%20We%20aimed%20to%20assess%20this%20effect%20under%20different%20roll-out%20strategies%20and%20explore%20key%20factors%20for%20resistance.%5CnMETHODS%3A%20We%20extended%20the%20Modelling%20Antiretroviral%20Drug%20Resistance%20In%20South%20Africa%20%28MARISA%29%20model%20to%20assess%20the%20effect%20of%20introducing%20LAI%20cabotegravir%20and%20rilpivirine%20in%20South%20Africa%20from%202025%20to%202045.%20The%20HIV%20transmission%20rate%20was%20recalibrated%20using%20incidence%20estimates%20from%20the%20Thembisa%20model.%20We%20considered%20three%20strategies%3A%20dolutegravir-based%20ART%20as%20per%20current%20guidelines%3B%20LAI%20cabotegravir%20and%20rilpivirine%20as%20a%20switching%20option%20for%20those%20with%20viral%20suppression%3B%20and%20LAI%20cabotegravir%20and%20rilpivirine%20for%20both%20switching%20and%20ART%20initiation.%20We%20assumed%20faster%20development%20of%20integrase%20strand%20transfer%20inhibitor%20%28INSTI%29%20resistance%20in%20individuals%20with%20viraemia%20%28%5Cu22651000%20copies%5C%2FmL%29%20on%20LAI%20cabotegravir%20and%20rilpivirine%20than%20those%20with%20viraemia%20on%20dolutegravir-based%20ART.%20We%20evaluated%20their%20effect%20on%20pre-treatment%20drug%20resistance%20%28PDR%29%20and%20transmitted%20drug%20resistance%20%28TDR%29%20for%20INSTI%20and%20rilpivirine%2C%20explored%20resistance%20mitigation%20strategies%2C%20and%20identified%20key%20uncertainties%20through%20one-at-a-time%20local%20and%20global%20sensitivity%20analyses.%5CnFINDINGS%3A%20By%202045%2C%20using%20LAI%20cabotegravir%20and%20rilpivirine%20for%20both%20switching%20and%20ART%20initiation%20was%20estimated%20to%20lead%20to%20higher%20INSTI%20resistance%20levels%2C%20with%2030%5Cu00b76%25%20INSTI%20PDR%20and%2011%5Cu00b73%25%20INSTI%20TDR%20at%2030%25%20LAI%20cabotegravir%20and%20rilpivirine%20coverage%2C%20compared%20with%2014%5Cu00b70%25%20INSTI%20PDR%20and%206%5Cu00b79%25%20INSTI%20TDR%20with%20continued%20oral%20dolutegravir-based%20ART.%20Rilpivirine%20resistance%20under%20the%20LAI%20cabotegravir%20and%20rilpivirine%20initiation%20and%20switch%20strategy%20was%20estimated%20to%20increase%20to%2041%5Cu00b70%25%20PDR%20and%2030%5Cu00b70%25%20TDR%2C%20compared%20with%206%5Cu00b77%25%20and%204%5Cu00b75%25%20with%20oral%20dolutegravir-based%20ART.%20Resistance%20levels%20were%20similar%20for%20LAI%20cabotegravir%20and%20rilpivirine%20as%20a%20switching%20option%20for%20those%20with%20viral%20suppression.%20A%20course%20of%20oral%20ART%20after%20LAI%20cabotegravir%20and%20rilpivirine%20interruption%20%28oral%20bridging%29%20decreased%20the%20risk%20of%20drug%20resistance%20due%20to%20the%20long%20pharmacokinetic%20tail%2C%20resulting%20in%2022%5Cu00b73%25%20INSTI%20PDR%20and%2026%5Cu00b70%25%20rilpivirine%20PDR%20when%20using%20LAI%20cabotegravir%20and%20rilpivirine%20for%20both%20switching%20and%20ART%20initiation.%20Key%20factors%20influencing%20resistance%20levels%20were%20care%20disengagement%20rates%2C%20LAI%20cabotegravir%20and%20rilpivirine%20coverage%2C%20and%20INSTI%20mutation%20reversion%20rates.%5CnINTERPRETATION%3A%20LAI%20cabotegravir%20and%20rilpivirine%20roll-out%20in%20South%20Africa%20should%20be%20cautious%20and%20targeted.%20Resistance%20risks%20may%20be%20mitigated%20through%20pre-treatment%20resistance%20testing%2C%20close%20monitoring%20of%20treatment%20outcomes%2C%20and%20efforts%20to%20increase%20retention%20in%20care.%5CnFUNDING%3A%20US%20National%20Institutes%20of%20Health%20National%20Institute%20of%20Allergy%20and%20Infectious%20Diseases%20and%20the%20Swiss%20National%20Science%20Foundation.%22%2C%22date%22%3A%222025-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2FS2214-109X%2825%2900350-X%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222214-109X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A40%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22Z777CJRQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Motlokwa%20et%20al.%22%2C%22parsedDate%22%3A%222025-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMotlokwa%2C%20Precious%20Kefilwe%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Survival%20among%20medically%20insured%20and%20treated%20head%20and%20neck%20cancer%20patients%20with%20and%20without%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BHIV%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B26%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%201973%26%23x2013%3B1982.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhiv.70143%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhiv.70143%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Survival%20among%20medically%20insured%20and%20treated%20head%20and%20neck%20cancer%20patients%20with%20and%20without%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Precious%20Kefilwe%22%2C%22lastName%22%3A%22Motlokwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20To%20assess%20the%20association%20of%20HIV%20and%20overall%20survival%20among%20medically%20insured%20head%20and%20neck%20cancer%20%28HNC%29%20patients%20in%20South%20Africa%20and%20to%20examine%20factors%20associated%20with%20the%20type%20of%20treatment%20received.%5CnMETHODS%3A%20We%20used%20reimbursement%20claims%20data%20from%20a%20South%20African%20medical%20insurance%20scheme%20database%20from%201%20January%202011%20to%201%20July%202020.%20We%20included%20individuals%20with%20at%20least%20two%20International%20Classification%20of%20Diseases%20%28ICD-10%29%20codes%20for%20HNC%20and%20at%20least%20one%20cancer%20treatment%20code%20within%20180%5Cu2009days%20of%20the%20HNC%20diagnosis.%20We%20used%20logistic%20regression%20to%20identify%20factors%20associated%20with%20receiving%20a%20specific%20type%20of%20cancer%20treatment%20and%20Cox%20proportional%20hazards%20models%20to%20examine%20factors%20associated%20with%20all-cause%20mortality.%5CnRESULTS%3A%20We%20included%20566%20HNC%20patients%2C%2049%20of%20whom%20lived%20with%20HIV%20and%20383%20were%20male.%20Patients%20with%20HIV%20were%20substantially%20younger%20at%20HNC%20diagnosis%20%28median%20age%3A%2052.5%5Cu2009years%29%20than%20patients%20without%20HIV%20%28median%20age%3A%2061.6%5Cu2009years%29.%20We%20found%20no%20clear%20association%20between%20HIV%20status%20and%20the%20treatment%20type%20received.%20The%20median%20survival%20was%203.78%5Cu2009years%20%2895%25%20confidence%20interval%20%5BCI%5D%203.01-6.08%29%20and%20the%20five-year%20survival%20was%2046.0%25%20%2895%25%20CI%2041.2%25-51.5%25%29.%20The%20risk%20of%20death%20was%20higher%20among%20patients%20with%20HIV%20than%20those%20without%20HIV%20%28adjusted%20hazard%20ratio%201.68%3B%2095%25%20CI%201.00-2.81%29.%5CnCONCLUSION%3A%20Medically%20insured%20HNC%20patients%20in%20South%20Africa%20with%20HIV%20had%20higher%20mortality%20than%20those%20without%20HIV.%20This%20underscores%20the%20importance%20of%20tailored%20cancer%20care%20strategies%20for%20HNC%20patients%20with%20HIV.%22%2C%22date%22%3A%222025-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fhiv.70143%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221468-1293%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22NMNPNZRP%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A37%3A33Z%22%7D%7D%2C%7B%22key%22%3A%224XW7ZM6N%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-26%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLow%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Immunodeficiency%2C%20HIV%20Viremia%2C%20and%20Incident%20Anal%20Cancer%20Among%20People%20With%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BOpen%20Forum%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%20%2812%29%2C%20S.%20ofaf693.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf693%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf693%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Immunodeficiency%2C%20HIV%20Viremia%2C%20and%20Incident%20Anal%20Cancer%20Among%20People%20With%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20V%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenni%22%2C%22lastName%22%3A%22Noble%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Among%20130%20992%20people%20with%20HIV%20%28PWH%29%20in%20South%20Africa%2C%2060%20anal%20cancers%20were%20diagnosed.%20Lower%20CD4%20counts%20and%2C%20to%20a%20lesser%20extent%2C%20higher%20HIV%20RNA%20viral%20loads%20were%20associated%20with%20an%20increased%20anal%20cancer%20risk.%20Maintaining%20high%20CD4%20counts%20may%20contribute%20to%20anal%20cancer%20prevention%20among%20PWH%20in%20South%20Africa.%22%2C%22date%22%3A%222025-11-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofaf693%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fofid%5C%2Farticle%5C%2Fdoi%5C%2F10.1093%5C%2Fofid%5C%2Fofaf693%5C%2F8321507%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222328-8957%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-11-27T09%3A21%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22P7P7KZAU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brazier%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBrazier%2C%20Ellen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBerry%2C%20Amanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKatz%2C%20Benjamin%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLewis%2C%20Judith%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDuda%2C%20Stephany%20N.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20development%20of%20IeDEA%26%23x2019%3Bs%20Treat%20All%20Dashboard%20on%20HIV%20care%20outcomes%20at%20participating%20clinics%20in%20Sub-Saharan%20Africa.%20%26lt%3Bi%26gt%3BmedRxiv%3A%20The%20Preprint%20Server%20for%20Health%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%202025.11.20.25340413.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.11.20.25340413%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2025.11.20.25340413%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20development%20of%20IeDEA%27s%20Treat%20All%20Dashboard%20on%20HIV%20care%20outcomes%20at%20participating%20clinics%20in%20Sub-Saharan%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amanda%22%2C%22lastName%22%3A%22Berry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Katz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%20T.%22%2C%22lastName%22%3A%22Lewis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephany%20N.%22%2C%22lastName%22%3A%22Duda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aggrey%22%2C%22lastName%22%3A%22Semeere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Jaquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%20Oteko%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francois%22%2C%22lastName%22%3A%22Dabis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Muhoza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Nash%22%7D%5D%2C%22abstractNote%22%3A%22Data%20dashboards%20are%20popular%20tools%20for%20communicating%20information%20and%20monitoring%20progress%20towards%20public%20health%20goals.%20To%20facilitate%20access%20to%20information%20on%20key%20metrics%20and%20emergent%20trends%20related%20to%20the%20roll-out%20of%20universal%20HIV%20treatment%20across%20diverse%20settings%2C%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20leveraged%20real-world%20service%20delivery%20data%20from%20clinics%20in%20sub-Saharan%20Africa%20to%20develop%201%29%20a%20publicly%20accessible%20interactive%20dashboard%20displaying%20regional%20and%20country-level%20metrics%20related%20to%20HIV%20care%20outcomes%20across%20IeDEA%20sites%20in%20sub-Saharan%20Africa%3B%20and%202%29%20a%20password-protected%20dashboard%20displaying%20similar%20metrics%20at%20the%20clinic%20level%20for%20staff%20at%20sites%20that%20contribute%20data%20to%20the%20IeDEA%20consortium.%20This%20paper%20describes%20the%20development%20of%20these%20dashboards%20and%20lessons%20learned.%22%2C%22date%22%3A%222025-11-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1101%5C%2F2025.11.20.25340413%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22369YB7BV%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A17%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22I7BNBUIF%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Andoh%20et%20al.%22%2C%22parsedDate%22%3A%222025-11-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAndoh%2C%20John%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20Katayoun%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Misinzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBasu%2C%20Partha%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMadliwa%2C%20Thamsanqa%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Cervical%20intraepithelial%20neoplasia%20progression%20and%20regression%20among%20women%20living%20with%20HIV%20in%20Zambia.%20%26lt%3Bi%26gt%3BHIV%20Medicine%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhiv.70134%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhiv.70134%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cervical%20intraepithelial%20neoplasia%20progression%20and%20regression%20among%20women%20living%20with%20HIV%20in%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Andoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katayoun%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Misinzo%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Partha%22%2C%22lastName%22%3A%22Basu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thamsanqa%22%2C%22lastName%22%3A%22Madliwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mulindi%20H.%22%2C%22lastName%22%3A%22Mwanahamuntu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Manasyan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20Cervical%20screening%20and%20precancer%20treatment%20are%20less%20effective%20in%20women%20living%20with%20HIV%20%28WLWH%29%20than%20in%20women%20without%20HIV.%20We%20assessed%20high-risk%20human%20papillomavirus%20%28HR-HPV%29%20infection%20and%20cervical%20disease%20progression%20among%20screened%20WLWH%20in%20Zambia.%5CnMETHODS%3A%20Participants%20underwent%20visual%20inspection%20with%20acetic%20acid%20%28VIA%29%2C%20HR-HPV%20testing%20and%20cervical%20biopsies%20at%20baseline%20and%20at%20follow-up%2030-36%5Cu2009months%20later.%20Women%20with%20positive%20VIA%20results%20or%20high-grade%20histology%20were%20offered%20treatment.%20We%20assessed%20HR-HPV%20and%20cervical%20disease%20prevalence%20at%20both%20timepoints%20and%20used%20multivariable%20logistic%20regression%20to%20identify%20factors%20associated%20with%20cervical%20disease%20progression%20and%20regression.%5CnRESULTS%3A%20Among%20241%20included%20women%2C%20HR-HPV%20prevalence%20declined%20from%2044%25%20%2895%25%20confidence%20interval%20%5BCI%5D%3A%2039%25-49%25%29%20at%20baseline%20to%2024%25%20%2895%25%20CI%3A%2019%25-31%25%29%20at%20follow-up.%20High-grade%20disease%20decreased%20from%2025%25%20%2895%25%20CI%3A%2020%25-31%25%29%20to%209%25%20%2895%25%20CI%3A%205%25-13%25%29.%20In%20analyses%20adjusted%20for%20age%2C%20CD4%20cell%20count%2C%20HIV%20RNA%20viral%20load%2C%20HR-HPV%20infection%20and%20histological%20results%20at%20baseline%2C%20precancer%20treatment%20was%20associated%20with%20increased%20odds%20of%20disease%20regression%20%28adjusted%20odds%20ratio%20%5BaOR%5D%3A%202.74%2C%2095%25%20CI%3A%201.08-7.06%29%20and%20reduced%20odds%20of%20progression%20%28aOR%3A%200.45%2C%2095%25%20CI%3A%200.11-1.64%29.%20One-third%20of%20women%20with%20high-grade%20disease%20at%20follow-up%20%287%5C%2F21%29%20had%20previously%20undergone%20precancer%20treatment.%5CnCONCLUSIONS%3A%20Cervical%20screening%20and%20precancer%20treatment%20are%20key%20to%20reducing%20cervical%20disease%20progression%20among%20WLWH%20and%20ultimately%20achieving%20cervical%20cancer%20elimination%2C%20but%20efforts%20to%20improve%20treatment%20effectiveness%20among%20WLWH%20must%20be%20balanced%20with%20the%20risk%20of%20overtreatment.%22%2C%22date%22%3A%222025-11-05%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fhiv.70134%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221468-1293%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A33%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22REQ75ZFT%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vreeman%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BVreeman%2C%20Rachel%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BYiannoutsos%2C%20Constantin%20T.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEdmonds%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeroy%2C%20Val%26%23xE9%3Briane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFatti%2C%20Geoffrey%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Rates%20of%20adherence%2C%20adherence%20measurement%2C%20and%20support%20services%20for%20children%20and%20adolescents%20living%20with%20HIV%20followed%20in%20global%20sites%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29.%20%26lt%3Bi%26gt%3BBMC%20Pediatrics%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B25%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20706.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-025-05939-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-025-05939-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Rates%20of%20adherence%2C%20adherence%20measurement%2C%20and%20support%20services%20for%20children%20and%20adolescents%20living%20with%20HIV%20followed%20in%20global%20sites%20of%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%20C.%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantin%20T.%22%2C%22lastName%22%3A%22Yiannoutsos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Edmonds%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pope%22%2C%22lastName%22%3A%22Kosalaraksa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beverly%22%2C%22lastName%22%3A%22Musick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winstone%22%2C%22lastName%22%3A%22Nyandiko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christelle%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Safari%22%2C%22lastName%22%3A%22Mbewe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fernando%22%2C%22lastName%22%3A%22Mejia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20L.%22%2C%22lastName%22%3A%22Scanlon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Supporting%20and%20improving%20antiretroviral%20therapy%20%28ART%29%20adherence%20and%20preventing%20the%20evolution%20of%20HIV%20drug%20resistance%20remain%20major%20challenges%20for%20children%20and%20adolescents%20living%20with%20HIV%20globally.%20In%20a%20large%20global%20HIV%20clinical%20data%20consortium%2C%20we%20sought%20to%20describe%20how%20global%20HIV%20care%20programs%20measure%20and%20support%20pediatric%20ART%20adherence%2C%20as%20well%20as%20patient-level%20measures%20of%20adherence.%5CnMETHODS%3A%20We%20prospectively%20collected%20site-level%20data%20between%20June%202014-March%202015%20using%20a%20site%20assessment%20survey%20and%20retrospectively%20examined%20patient-level%20data%20collected%20during%20routine%20clinical%20care%2C%20to%20provide%20a%20comprehensive%20assessment%20of%20pediatric%20ART%20adherence%20across%20the%20International%20Epidemiology%20Databases%20to%20Evaluate%20AIDS%20%28IeDEA%29%20cohort%2C%20in%20six%20global%20regions.%20All%20regions%20capturing%20patient-level%20data%20on%20adherence%20by%20any%20measure%20for%20children%20living%20with%20HIV%20aged%20less%20than%2014%5Cu00a0years%20between%202000-2015%20were%20asked%20to%20contribute%20data.%20ART%20adherence%20was%20conceptualized%20as%20a%20binomial%20variable%20of%20%26quot%3Bgood%26quot%3B%20%28greater%20than%2090%25%29%20or%20%26quot%3Bpoor%26quot%3B%20%2890%25%20or%20less%29%20adherence%20per%20visit.%5CnRESULTS%3A%20Clinical%20staff%20from%20180%20pediatric%20sites%20in%2045%20countries%20completed%20the%20adherence%20survey.%20Clinician%20adherence%20assessment%20%28used%20at%2087%25%20of%20sites%29%20and%20pharmacy%20refills%20%2886%25%20of%20sites%29%20were%20the%20most%20common%20adherence%20measurement%20methods%20used%20globally.%20Counseling%20focused%20on%20adherence%20was%20the%20most%20commonly%20available%20support%20service%2C%20%2894%25%20of%20sites%29.%2028%2C664%20pediatric%20patients%20had%20at%20least%20one%20adherence%20measurement%2C%20to%20be%20included%20for%20adherence%20analyses.%20In%20East%20Africa%20and%20Southern%20Africa%2C%20higher%20baseline%20CD4%20counts%20were%20associated%20with%20a%20greater%20likelihood%20of%20viral%20suppression%3B%20however%2C%20in%20Central%20and%20South%20America%20and%20the%20Caribbean%20%28CCASAnet%29%20and%20Asia-Pacific%2C%20we%20did%20not%20find%20a%20consistent%20relationship%20between%20baseline%20CD4%20count%20and%20the%20likelihood%20of%20viral%20suppression.%20We%20found%20evidence%20that%20very%20young%20children%20%28%26lt%3B%5Cu20092%5Cu00a0years%20of%20age%29%2C%20older%20children%20%28%26gt%3B%5Cu200910%5Cu00a0years%20of%20age%29%2C%20and%20males%20were%20less%20likely%20to%20experience%20viral%20suppression%20in%20East%20Africa%20and%20Southern%20Africa.%5CnCONCLUSION%3A%20These%20findings%20indicate%20that%20the%20majority%20of%20global%20pediatric%20HIV%20care%20services%20routinely%20measure%20ART%20adherence%20for%20children%20living%20with%20HIV%3B%20however%2C%20few%20sites%20use%20objective%20or%20validated%20measures.%20Identifying%20subgroups%20of%20children%20and%20youth%20at%20highest%20risk%20for%20non-adherence%20allows%20care%20programs%20to%20target%20those%20most%20in%20need%20of%20adherence%20support%20or%20resistance%20monitoring.%22%2C%22date%22%3A%222025-10-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12887-025-05939-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2431%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A34%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22SR8W7DC4%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Keal%20et%20al.%22%2C%22parsedDate%22%3A%222025-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKeal%2C%20Josephine%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3Bvan%20Dongen%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFerreria%2C%20Thalia%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSorour%2C%20Gillian%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Care%20for%20the%20Caregiver%3A%20How%20Caregiver%20Mortality%20Affects%20Treatment%20Outcomes-An%20Observational%20Cohort%20Study.%20%26lt%3Bi%26gt%3BAIDS%20and%20Behavior%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B29%26lt%3B%5C%2Fi%26gt%3B%20%2810%29%2C%20S.%203087%26%23x2013%3B3094.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04760-5%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04760-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Care%20for%20the%20Caregiver%3A%20How%20Caregiver%20Mortality%20Affects%20Treatment%20Outcomes-An%20Observational%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josephine%22%2C%22lastName%22%3A%22Keal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thalia%22%2C%22lastName%22%3A%22Ferreria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gillian%22%2C%22lastName%22%3A%22Sorour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%5D%2C%22abstractNote%22%3A%22Despite%20improvements%20in%20HIV%20management%2C%20children%20and%20adolescents%20living%20with%20HIV%20remain%20vulnerable.%20Caregiver%20mortality%20in%20a%20large%20paediatric%20and%20adolescent%20HIV%20clinic%20in%20Johannesburg%20is%20described%20and%20the%20effect%20of%20the%20death%20of%20a%20caregiver%20on%20children%20and%20adolescents%26%23039%3B%20HIV%20treatment%20outcomes%20was%20investigated.%20We%20analysed%20retrospective%20longitudinal%20data%20and%20included%20children%20or%20adolescents%20attending%20the%20clinic%20between%2001%20January%20and%2031%20December%202021%20divided%20into%20those%20with%20documented%20primary%20caregiver%20mortality%20and%20those%20without%20%28ever%20documented%29.%20Viral%20load%2C%20treatment%20regimens%2C%20CD4%2C%20and%20anthropometry%20were%20analysed%20for%202021.%20Caregiver%20vital%20status%20was%20recorded%20in%201171%20%2893%25%29%20of%20the%201260%20patients%20attending%20in%202021.%20In%20115%20children%20or%20adolescents%20%2810%25%29%20we%20found%20a%20documented%20death%20of%20caregiver%28s%29.%20Amongst%201120%20mothers%2C%20100%20%289%25%29%20had%20died%3B%20of%20460%20fathers%2C%2018%20%284%25%29%20had%20died%20and%20one%20%281%25%29%20of%20100%20other%20caregivers%20had%20died.%20A%20large%20number%20%28n%5Cu2009%3D%5Cu200954%20%5B45%25%5D%29%20of%20the%20119%20deaths%20occurred%20between%202016%20and%202021%20and%2066%20%2869%25%29%20after%20the%20child%5C%2Fadolescent%26%23039%3Bs%20enrolment%20in%20the%20clinic.%20In%202021%2C%20stunting%20and%20wasting%20were%20more%20common%20in%20the%20participants%20with%20caregiver%20death%20than%20those%20without%20%28%5Cu03c72%5Cu2009%3D%5Cu20094.98%2C%206.64%2C%20p%5Cu2009%3D%5Cu20090.01%20and%200.03%20respectively%29.%20No%20significant%20difference%20was%20seen%20between%20the%20groups%20for%20viral%20load%2C%20treatment%20regimens%20and%20CD4%20counts.%20Caregiver%20death%20was%20incompletely%20captured%20in%20the%20clinic%20database%2C%20suggesting%20that%20clinicians%20were%20unaware%20of%20the%20death%20of%20a%20caregiver.%20Children%20experiencing%20the%20death%20of%20a%20caregiver%20were%20more%20likely%20to%20be%20malnourished.%20We%20propose%20increasing%20attention%20on%20the%20wellbeing%20of%20caregivers%20in%20paediatric%20HIV%20services.%22%2C%22date%22%3A%222025-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10461-025-04760-5%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221573-3254%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-11-13T13%3A05%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22VNUXZ38G%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Skrivankova%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSkrivankova%2C%20Veronika%20Whitesell%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Stephan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTlali%2C%20Mpho%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Incidence%20and%20prognostic%20factors%20of%20self-harm%20and%20subsequent%20unnatural%20death%20in%20South%20Africa%3A%20A%20cohort%20study.%20%26lt%3Bi%26gt%3BPLoS%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B22%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20e1004765.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004765%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pmed.1004765%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Incidence%20and%20prognostic%20factors%20of%20self-harm%20and%20subsequent%20unnatural%20death%20in%20South%20Africa%3A%20A%20cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20Whitesell%22%2C%22lastName%22%3A%22Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Bennett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aimee%22%2C%22lastName%22%3A%22Wesso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Morna%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Self-harm%20is%20a%20major%20public%20health%20concern%20globally%20and%20in%20South%20Africa.%20Individuals%20with%20a%20history%20of%20self-harm%20are%20at%20increased%20risk%20of%20unnatural%20death%2C%20including%20suicide%20and%20fatal%20accidents.%20This%20study%20investigates%20the%20incidence%20and%20predictors%20of%20self-harm%20and%20its%20role%20as%20a%20predictor%20for%20subsequent%20unnatural%20death.%5CnMETHODS%20AND%20FINDINGS%3A%20We%20conducted%20a%20cohort%20study%20using%20insurance%20claims%20and%20vital%20registration%20data%20from%20beneficiaries%20of%20South%20African%20medical%20insurance%20schemes%20%282011-2022%29%2C%20aged%2010%20years%20or%20older.%20We%20estimated%20the%20cause-specific%20cumulative%20incidences%20of%20healthcare%20encounters%20for%20intentional%20self-harm%20%28International%20Classification%20of%20Diseases%2010th%20Revision%20%5BICD-10%5D%20codes%20X60-X84%29%20and%20unnatural%20deaths%20%28ICD-10%20codes%20V01-Y98%29%2C%20using%20the%20Aalen-Johansen%20method.%20We%20assessed%20predictors%20of%20both%20outcomes%20using%20Cox%20regression.%20We%20followed%201%2C356%2C119%20beneficiaries%20%28median%20age%2033%20years%2C%2052.2%25%20female%29%20for%20a%20median%20of%203%20years%2C%20during%20which%207%2C510%20%280.6%25%29%20had%20a%20healthcare%20encounter%20for%20self-harm.%20The%205-year%20cumulative%20incidence%20of%20self-harm%20ranged%20from%200.2%25%20in%20males%20aged%2010-14%20to%202.1%25%20in%20females%20aged%2015-24.%20Sex%2C%20age%2C%20and%20mental%20disorders%20were%20strong%20predictors%20for%20self-harm%2C%20while%20HIV%20was%20a%20modest%20predictor.%20Among%20individuals%20who%20survived%20a%20self-harm%20event%2C%20the%20five-year%20cumulative%20incidence%20of%20unnatural%20death%20was%203.43%25%20%2895%25%20CI%20%5B2.38%2C%204.76%5D%29%20for%20males%20and%200.77%25%20%2895%25%20CI%20%5B0.48%2C%201.19%5D%29%20for%20females.%20Non-fatal%20self-harm%20was%20a%20strong%20predictor%20of%20subsequent%20unnatural%20death%20in%20both%20males%20%28hazard%20ratio%20%5BHR%5D%207.03%2C%2095%25%20CI%20%5B5.27%2C%209.39%5D%29%20and%20females%20%28HR%204.63%2C%2095%25%20CI%20%5B3.00%2C%207.15%5D%29.%20The%20study%26%23039%3Bs%20main%20limitations%20include%20potential%20under-ascertainment%20of%20self-harm%20incidence%20due%20to%20reliance%20on%20routine%20data%2C%20and%20the%20unavailability%20of%20the%20exact%20cause%20of%20death%2C%20preventing%20analysis%20of%20suicide.%5CnCONCLUSION%3A%20Self-harm%20is%20common%20among%20beneficiaries%20of%20South%20African%20private%20medical%20insurance%2C%20with%20the%20highest%20risk%20in%20young%20females%20and%20individuals%20with%20mental%20disorders.%20These%20groups%20may%20benefit%20from%20targeted%20screening%20and%20early%20intervention.%20Non-fatal%20self-harm%20was%20a%20strong%20predictor%20of%20subsequent%20unnatural%20death%2C%20underscoring%20the%20need%20for%20suicide-specific%20brief%20interventions%20for%20individuals%20presenting%20with%20self-harm.%22%2C%22date%22%3A%222025-09-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pmed.1004765%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221549-1676%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-30T14%3A40%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22XTCS2W9X%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-09-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMadlala%2C%20Hlengiwe%20P.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNyemba%2C%20Dorothy%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDinkele%2C%20Ryan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSmith%2C%20Mariette%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Infectious%20morbidity%20among%20children%20HIV-exposed%20uninfected%20in%20South%20Africa%3A%20elevated%20risk%20in%20infancy%20but%20not%20thereafter.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004358%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004358%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infectious%20morbidity%20among%20children%20HIV-exposed%20uninfected%20in%20South%20Africa%3A%20elevated%20risk%20in%20infancy%20but%20not%20thereafter%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hlengiwe%20P.%22%2C%22lastName%22%3A%22Madlala%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorothy%20C.%22%2C%22lastName%22%3A%22Nyemba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Dinkele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariette%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20F.%22%2C%22lastName%22%3A%22Cotton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudzani%22%2C%22lastName%22%3A%22Muloiwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Graeme%22%2C%22lastName%22%3A%22Spittal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Kroon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Increased%20risk%20of%20infectious%20morbidity%20and%20hospitalisation%20has%20been%20reported%20during%20infancy%20among%20children%20HIV-exposed%20uninfected%20%28CHEU%29%20compared%20to%20children%20HIV-unexposed%20uninfected%20%28CHUU%29.%20However%2C%20data%20on%20risks%20beyond%20infancy%20are%20limited.%5CnMETHODS%3A%20We%20enrolled%20pregnant%20women%20with%20and%20without%20HIV%20from%20a%20primary%20healthcare%20facility%20in%20a%20lower-income%20area%20in%20Cape%20Town%2C%20South%20Africa%20%282017-2018%29.%20We%20tracked%20their%20children%26%23039%3Bs%20HIV%20test%20results%20and%20hospitalisations%20using%20routine%20electronic%20healthcare%20data.%20We%20previously%20reported%20increased%20rates%20of%20infectious-cause%20hospitalisation%20among%20CHEU%20in%20the%20first%20year%20of%20life%2C%20and%20now%20extend%20the%20analysis%20to%20cover%20the%20period%20from%20age%201%20to%20%26lt%3B5%5Cu200ayears.%20Using%20random-effects%20Poisson%20regression%2C%20we%20calculated%20adjusted%20incidence%20rate%20ratios%20%28aIRR%29%20for%20infectious-cause%20hospitalisation%20among%20CHEU%20vs%20CHUU%2C%20clustered%20by%20infant%20and%20adjusted%20for%20child%20sex%20and%20vaccination%20status%2C%20maternal%20age%20and%20education%2C%20and%20housing%20type.%5CnRESULTS%3A%20Among%20446%20CHEU%20and%20455%20CHUU%2C%20147%20admissions%20occurred%20from%20age%201%20to%20%26lt%3B5%5Cu200ayears%3B%20with%2059%25%20%28n%5Cu200a%3D%5Cu200a87%29%20due%20to%20infections.%20All-cause%20hospitalisation%20occurred%20in%209.2%25%20of%20CHEU%20and%2010.5%25%20of%20CHUU%3B%20infectious-cause%20hospitalisation%20occurred%20in%206.5%25%20of%20CHEU%20and%207.3%25%20of%20CHUU%20with%20crude%20incidence%20rates%20of%202.4%20per%20100%20child-years%20for%20both%20groups%20%28IRR%5Cu200a%3D%5Cu200a1.0%3B%2095%25%20CI%200.6-1.6%29.%20Adjusted%20analyses%20showed%20no%20evidence%20of%20increased%20hospitalisation%20among%20CHEU%20%28aIRR%5Cu200a%3D%5Cu200a0.71%3B%2095%25%20CI%200.36-1.41%29.%5CnCONCLUSIONS%3A%20Elevated%20risk%20of%20infectious-cause%20hospitalisation%20among%20CHEU%20did%20not%20persist%20beyond%20the%20first%20year%20of%20life.%20These%20findings%20highlight%20infancy%20as%20a%20key%20window%20for%20targeted%20interventions%2C%20while%20providing%20reassurance%20regarding%20longer-term%20infectious%20morbidity%20risk.%22%2C%22date%22%3A%222025-09-24%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004358%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-5571%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-11-19T15%3A13%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22XXHM3ZJN%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222025-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20Ver%26%23xF3%3Bnica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLow%2C%20Nicola%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Anal%20Cancer%20Incidence%20Rates%20Among%20Men%20and%20Women%20With%20and%20Without%20HIV%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BOpen%20Forum%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B12%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%20ofaf537.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf537%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fofid%5C%2Fofaf537%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Anal%20Cancer%20Incidence%20Rates%20Among%20Men%20and%20Women%20With%20and%20Without%20HIV%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Ver%5Cu00f3nica%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Low%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenni%22%2C%22lastName%22%3A%22Noble%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20More%20than%207.5%20million%20people%20in%20South%20Africa%20have%20HIV%2C%20but%20little%20is%20known%20about%20the%20association%20of%20HIV%20and%20anal%20cancer%20incidence.%20We%20examined%20anal%20cancer%20incidence%20in%20a%20large%20South%20African%20cohort%20of%20insured%20men%20and%20women.%5CnMETHODS%3A%20We%20conducted%20a%20cohort%20study%20using%20reimbursement%20claims%20data%20from%20a%20South%20African%20medical%20insurance%20scheme%20%2801%5C%2F2011-07%5C%2F2020%29%20to%20assess%20anal%20cancer%20rates%20among%20people%20with%20and%20without%20HIV%20aged%20%5Cu226518%20years.%20We%20estimated%20adjusted%20hazard%20ratios%20%28aHRs%29%20for%20the%20association%20of%20HIV%20and%20incident%20anal%20cancer%20using%20flexible%20parametric%20survival%20models.%20Covariates%20included%20sex%2C%20age%2C%20calendar%20year%2C%20a%20history%20of%20genital%20warts%20and%20other%20sexually%20transmitted%20infections%2C%20and%20in%20women%2C%20cervical%20precancer.%5CnRESULTS%3A%20We%20included%201%20068%20915%20people%20of%20whom%2069%20985%20%287%25%29%20were%20living%20with%20HIV.%20Over%203%20933%20145%20person-years%2C%20122%20anal%20cancers%20were%20diagnosed%20%28crude%20rate%3A%203.1%5C%2F100%20000%20person-years%3B%2095%25%20confidence%20intervals%20%5BCI%5D%202.6-3.7%29.%20People%20with%20HIV%20had%20a%204-fold%20higher%20anal%20cancer%20risk%20than%20people%20without%20HIV%20%28aHR%204.43%3B%2095%25%20CI%202.44-8.04%29.%20While%20anal%20cancer%20rates%20were%20similar%20among%20men%20and%20women%2C%20older%20age%20%28%5Cu226565%20vs%2045-54%20years%3B%20aHR%205.01%3B%2095%25%20CI%3A%202.94-8.53%29%2C%20a%20history%20of%20genital%20warts%20%28aHR%207.56%3B%2095%25%20CI%3A%202.28-25.07%29%2C%20and%20among%20women%2C%20a%20prior%20cervical%20precancer%20diagnosis%20%28aHR%205.70%3B%2095%25%20CI%201.75-18.58%29%20were%20associated%20with%20a%20higher%20anal%20cancer%20risk.%5CnCONCLUSIONS%3A%20In%20South%20Africa%2C%20men%20and%20women%20with%20HIV%2C%20older%20individuals%2C%20people%20with%20a%20history%20of%20genital%20warts%2C%20and%20women%20with%20a%20prior%20cervical%20precancer%20diagnosis%20might%20benefit%20from%20prioritized%20access%20to%20anal%20cancer%20screening.%22%2C%22date%22%3A%222025-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fofid%5C%2Fofaf537%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222328-8957%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-30T14%3A39%3A54Z%22%7D%7D%2C%7B%22key%22%3A%225BP8T8BY%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Phillips%20et%20al.%22%2C%22parsedDate%22%3A%222025-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhillips%2C%20Tamsin%20K.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGomba%2C%20Yolanda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMogoba%2C%20Pheposadi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPhelanyane%2C%20Florence%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Routine%20Electronic%20Mother-Infant%20Data%20%28REMInD%29%3A%20A%20proof-of-Concept%20Data%20to%20Care%20Study%20to%20Support%20Retention%20in%20Maternal%20HIV%20Treatment%20and%20Infant%20HIV%20Testing%20in%20Cape%20Town%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BAIDS%20and%20Behavior%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B29%26lt%3B%5C%2Fi%26gt%3B%20%289%29%2C%20S.%202689%26%23x2013%3B2700.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04726-7%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10461-025-04726-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Routine%20Electronic%20Mother-Infant%20Data%20%28REMInD%29%3A%20A%20proof-of-Concept%20Data%20to%20Care%20Study%20to%20Support%20Retention%20in%20Maternal%20HIV%20Treatment%20and%20Infant%20HIV%20Testing%20in%20Cape%20Town%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamsin%20K.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yolanda%22%2C%22lastName%22%3A%22Gomba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pheposadi%22%2C%22lastName%22%3A%22Mogoba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florence%22%2C%22lastName%22%3A%22Phelanyane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%20H.%22%2C%22lastName%22%3A%22Chi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Clouse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucia%22%2C%22lastName%22%3A%22Knight%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Landon%22%2C%22lastName%22%3A%22Myer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elaine%20J.%22%2C%22lastName%22%3A%22Abrams%22%7D%5D%2C%22abstractNote%22%3A%22Data%20to%20Care%20%28D2C%29%20strategies-%20using%20routine%20data%20to%20identify%20and%20re-engage%20people%20living%20with%20HIV%20who%20are%20not%20in%20care-%20have%20shown%20promise%20in%20high-income%20settings%20but%20remain%20underexplored%20in%20lower-resource%20and%20vertical%20HIV%20transmission%20prevention%20%28VTP%29%20contexts.%20In%20this%20prospective%2C%20single-arm%2C%20proof-of-concept%20study%2C%20we%20used%20facility-linked%20public%20sector%20electronic%20medical%20records%20%28Provincial%20Health%20Data%20Centre%20%5BPHDC%5D%20data%29%20to%20identify%2C%20validate%20and%20trace%20postpartum%20VTP%20gaps%20among%20336%20mothers%20living%20with%20HIV%20and%20their%20infants%20in%20Cape%20Town%2C%20South%20Africa%20%28March%202021-April%202022%29.%5Cu00a0Of%20302%20observed%20gaps%2C%20123%20%2841%25%29%20were%20false%2C%20while%20179%20%2859%25%29%20were%20probable%20gaps%20affecting%20133%20mother-infant%20pairs.%20Overall%2C%2016%25%20of%20mothers%20did%20not%20link%20to%20HIV%20care%20within%2012%20weeks%20postpartum%20and%2013%25%20had%20ART%20dispensing%20gaps%2C%20while%2010%25%20and%2017%25%20of%20infants%20had%20no%20HIV%20test%20around%2010%20weeks%20and%20six%20months%2C%20respectively.%20Only%20100%20%2856%25%29%20probable%20gaps%20were%20confirmed%20through%20telephonic%20tracing%2C%20with%2047%20mothers%20subsequently%20re-linked%20to%20care.%20Mobility%2C%20stigma%2C%20and%20employment%20challenges%20contributed%20to%20disengagement.%20While%20our%20D2C%20approach%20streamlined%20tracing%20efforts%2C%20re-engagement%20remained%20difficult.%20Strategies%20integrating%20D2C%20approaches%20with%20interventions%20addressing%20social%20determinants%20are%20needed.%22%2C%22date%22%3A%222025-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10461-025-04726-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221573-3254%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-30T14%3A24%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22KHYDH9MU%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMureithi%2C%20Fiona%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEvans%2C%20Denise%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHuwa%2C%20Jacqueline%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Mental%2C%20physical%2C%20and%20respiratory%20health%20in%20people%20with%20tuberculosis%20in%20Southern%20Africa%3A%20a%20multi-country%20cohort%20analysis.%20%26lt%3Bi%26gt%3BBMC%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B23%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20485.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12916-025-04321-6%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12916-025-04321-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mental%2C%20physical%2C%20and%20respiratory%20health%20in%20people%20with%20tuberculosis%20in%20Southern%20Africa%3A%20a%20multi-country%20cohort%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fiona%22%2C%22lastName%22%3A%22Mureithi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cordelia%22%2C%22lastName%22%3A%22Kunzekwenyika%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelly%22%2C%22lastName%22%3A%22Jinga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amina%22%2C%22lastName%22%3A%22Fernando%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agness%22%2C%22lastName%22%3A%22Thawani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%20C.%22%2C%22lastName%22%3A%22Sweetland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Southern%20Africa%20%28IeDEA-SA%29%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Tuberculosis%20%28TB%29%20affects%20people%26%23039%3Bs%20quality%20of%20life%20%28QoL%29.%20We%20prospectively%20monitored%20physical%20and%20mental%20health-related%20QoL%20over%20time%20in%20people%20with%20TB%20in%20the%20Southern%20African%20region%20with%20a%20high%20HIV%20and%20TB%20burden.%5CnMETHODS%3A%20Adults%20aged%5Cu2009%5Cu2265%5Cu200915%20years%20with%20pulmonary%20TB%20were%20enrolled%20in%20five%20cohorts%20in%20Malawi%2C%20Mozambique%2C%20South%20Africa%2C%20Zambia%2C%20and%20Zimbabwe%20from%20October%202022%20to%20September%202024.%20We%20assessed%20six%20QoL%20outcomes%20using%20validated%20instruments%20at%20the%20start%20%28baseline%29%2C%20end%20of%20treatment%2C%20and%206%20months%20post-treatment%3A%20symptoms%20of%20depression%20%28PHQ-9%29%2C%20mental%20and%20physical%20health%20%28SF-12%20mental%2C%20SF12-MC%2C%20SF-12%20physical%20component%2C%20SF12-PC%29%2C%20physical%20fitness%20%286-Minute%20Walk%20Test%2C%206MWT%3B%201-min%20Sit-To-Stand%20Test%2C%20STST%29%2C%20and%20respiratory%20health%20%28Saint-George-Respiratory-Questionnaire%2C%20SGRQ%29.%20Missing%20QoL%20scores%20were%20imputed%20with%20multivariate%20imputation%20by%20chained%20equations.%20We%20compared%20the%20proportion%20of%20participants%20with%20impaired%20QoL%2C%20defining%20impairment%20based%20on%20outcome-specific%20cut-off%20values.%20We%20also%20estimated%20changes%20in%20QoL%20scores%20and%20examined%20their%20associations%20with%20baseline%20characteristics%20using%20Bayesian%20multivariable%20regression%20models.%5CnRESULTS%3A%20We%20included%201438%20participants%20with%20a%20median%20follow-up%20of%20344%20days%20%28interquartile%20range%20%5BIQR%5D%20183-373%29.%20The%20median%20age%20was%2039%20years%20%28IQR%2030-50%29%3B%2067%25%20were%20male%2C%20and%2039%25%20living%20with%20HIV.%20At%20baseline%2C%2049%25%20had%20symptoms%20of%20depression%2C%2073%25%20had%20impaired%20mental%20health%20and%2092%25%20impaired%20physical%20health-related%20QoL%2C%2068-74%25%20had%20reduced%20physical%20fitness%20%2868%25%3A%206MWT%2C%2074%25%3A%20STST%29%2C%20and%2078%25%20impaired%20respiratory%20health.%20All%20QoL%20outcomes%20improved%20by%20the%20end%20of%20treatment%2C%20notably%20depressive%20symptoms%20%2848%25%20to%205%25%29%2C%20mental%20health-related%20QoL%20%2873%25%20to%2028%25%29%2C%20and%20respiratory%20health%20%2878%25%20to%2011%25%29.%20Most%20QoL%20impairments%20continued%20to%20decrease%20post-treatment%2C%20especially%20physical%20and%20respiratory%20health%3B%20depressive%20symptoms%20remained%20below%205%25.%20Across%20QoL%20domains%20and%20study%20visits%2C%20better%20outcomes%20were%20associated%20with%20age%5Cu2009%26lt%3B%5Cu200930%20%2883%25%20probability%29%2C%20and%20worse%20outcomes%20with%20female%20gender%20%2886%25%29%20and%20a%20prior%20TB%20history%20%2889%25%29.%20Living%20with%20HIV%20and%20alcohol%20drinking%20were%20associated%20with%20worse%20QoL%20only%20at%20baseline%20%2888%25%20and%2087%25%29.%5CnCONCLUSIONS%3A%20TB%20negatively%20impacts%20QoL%20across%20physical%2C%20mental%2C%20and%20social%20domains%2C%20including%20post-treatment.%20The%20study%20highlights%20the%20need%20for%20integrated%20mental%20and%20physical%20healthcare%20and%20rehabilitation%20during%20TB%20treatment%20and%20beyond%2C%20especially%20for%20high-risk%20populations%2C%20to%20address%20the%20long-term%20impact%20of%20TB%20on%20QoL.%22%2C%22date%22%3A%222025-08-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12916-025-04321-6%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221741-7015%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A33%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22WFQNLBC3%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Benade%20et%20al.%22%2C%22parsedDate%22%3A%222025-08-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBenade%2C%20Mariet%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaskew%2C%20Mhairi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChilembo%2C%20Phillip%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWa%20Mwansa%2C%20Mwansa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSavory%2C%20Theodora%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Patterns%20of%20engagement%20in%20care%20during%20clients%26%23x2019%3B%20first%2012%20months%20after%20HIV%20treatment%20initiation%20in%20Zambia%3A%20a%20retrospective%20cohort%20analysis%20using%20routinely%20collected%20data.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e017930.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017930%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017930%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patterns%20of%20engagement%20in%20care%20during%20clients%27%20first%2012%20months%20after%20HIV%20treatment%20initiation%20in%20Zambia%3A%20a%20retrospective%20cohort%20analysis%20using%20routinely%20collected%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariet%22%2C%22lastName%22%3A%22Benade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mhairi%22%2C%22lastName%22%3A%22Maskew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Phillip%22%2C%22lastName%22%3A%22Chilembo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mwansa%22%2C%22lastName%22%3A%22Wa%20Mwansa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theodora%22%2C%22lastName%22%3A%22Savory%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brooke%22%2C%22lastName%22%3A%22Nichols%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lloyd%20B.%22%2C%22lastName%22%3A%22Mulenga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Suilanji%22%2C%22lastName%22%3A%22Sivile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khozya%20Davie%22%2C%22lastName%22%3A%22Zyambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sydney%22%2C%22lastName%22%3A%22Rosen%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20first%20year%20after%20HIV%20treatment%20initiation%20or%20re-initiation%20is%20the%20period%20of%20highest%20risk%20of%20a%20treatment%20interruption%20or%20disengagement%2C%20yet%20little%20is%20known%20about%20the%20timing%2C%20patterns%20and%20effects%20of%20interruptions%20in%20the%20early%20treatment%20period.%5CnMETHODS%3A%20Using%20routinely%20collected%20electronic%20medical%20record%20data%20from%20543%20Zambian%20facilities%20from%202018%20to%202023%2C%20we%20described%20patterns%20of%20engagement%20during%20the%20first%20year%20of%20HIV%20treatment.%20We%20defined%20engagement%20patterns%20for%20months%200-6%20and%20months%207-12%20after%20initiation%20or%20reinitiation%20as%20%281%29%20continuous%20%28attended%20all%20scheduled%20clinic%20and%20medication%20pickup%20visits%20as%20planned%3B%20%282%29%20cyclical%20%28attended%20%5Cu22651%20visits%20late%20%26gt%3B28%5Cu2009days%20but%20returned%20to%20and%20remained%20in%20care%29%20or%20%283%29%20disengaged%20%28missed%20a%20scheduled%20visit%20by%20%26gt%3B28%5Cu2009days%20and%20had%20no%20evidence%20of%20return%29.%5CnRESULTS%3A%20Our%20sample%20population%20comprised%20159%5Cu2009429%20adult%20participants%20%2861%25%20female%2C%20median%20age%2033%29.%20Of%20the%20513%5Cu2009322%20interactions%20observed%20%5Cu226412%20months%20after%20initiation%2C%2053%25%20occurred%20as%20planned%2C%2022%25%20were%20late%20%5Cu226428%20days%20late%2C%209%25%20were%20%26gt%3B28%5Cu2009days%20late%2C%20and%2017%25%20were%20scheduled%20but%20never%20attended.%20In%200-6%20months%20after%20initiation%2C%2051%25%20clients%20were%20continuously%20engaged%2C%2012%25%20cyclically%20engaged%20and%2033%25%20disengaged.%20Two-thirds%20of%20disengagers%20%2821%25%20of%20cohort%29%20did%20not%20return%20after%20the%20initiation%20visit.%20During%20months%207-12%2C%20most%20clients%20who%20had%20been%20continuously%20engaged%20in%20months%200-6%20%2854%25%29%20remained%20continuous%2C%20while%2018%25%20moved%20to%20cyclical%20engagement.%20Among%20cyclical%20engagers%20in%20months%200-6%2C%20nearly%20half%20%2847%25%29%20moved%20to%20being%20continuously%20engaged%20by%20month%2012.%20Only%2034%25%20of%20the%20study%20population%20remained%20engaged%20continuously%20by%20the%20end%20of%20the%2012-month%20period.%5CnCONCLUSIONS%3A%20Fewer%20than%2060%25%20of%20clients%20initiating%20antiretroviral%20therapy%20care%20between%202018%20and%202022%20at%20Zambian%20facilities%20remained%20continuously%20engaged%20at%20month%206%20and%2034%25%20at%20month%2012.%20Cyclical%20engagement%20and%20frequent%20interruptions%20should%20be%20accepted%20as%20the%20norm%20and%20models%20of%20service%20delivery%20designed%20to%20accommodate%20them.%22%2C%22date%22%3A%222025-08-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-017930%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222059-7908%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A33%3A36Z%22%7D%7D%2C%7B%22key%22%3A%225Q9NZZF9%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ruffieux%20et%20al.%22%2C%22parsedDate%22%3A%222025-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJoska%2C%20John%20A.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLang%2C%20Raynell%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZheng%2C%20Chunyan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Life-years%20lost%20associated%20with%20mental%20disorders%20in%20people%20with%20HIV%3A%20a%20cohort%20study%20in%20South%20Africa%2C%20Canada%20and%20the%20United%20States.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%288%29%2C%20S.%20e70023.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70023%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.70023%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Life-years%20lost%20associated%20with%20mental%20disorders%20in%20people%20with%20HIV%3A%20a%20cohort%20study%20in%20South%20Africa%2C%20Canada%20and%20the%20United%20States%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20A.%22%2C%22lastName%22%3A%22Joska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raynell%22%2C%22lastName%22%3A%22Lang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunyan%22%2C%22lastName%22%3A%22Zheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20D.%22%2C%22lastName%22%3A%22Kirk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Silverberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonia%22%2C%22lastName%22%3A%22Napravnik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%22%2C%22lastName%22%3A%22Gebo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20J.%20Eron%22%2C%22lastName%22%3A%22Jr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brenna%20C.%22%2C%22lastName%22%3A%22Hogan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keri%20N.%22%2C%22lastName%22%3A%22Althoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20J.%22%2C%22lastName%22%3A%22Grelotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mona%22%2C%22lastName%22%3A%22Loutfy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20F.%22%2C%22lastName%22%3A%22Rebeiro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20People%20with%20HIV%20%28PWH%29%20have%20a%20high%20burden%20of%20mental%20health%20disorders%2C%20which%20contribute%20to%20increased%20mortality%20due%20to%20elevated%20rates%20of%20physical%20illness%2C%20suicide%20or%20fatal%20accidents.%20Additionally%2C%20mental%20health%20disorders%20can%20adversely%20affect%20antiretroviral%20therapy%20%28ART%29%20adherence%2C%20leading%20to%20increased%20HIV-related%20mortality.%20This%20study%20aims%20to%20quantify%20the%20difference%20in%20mortality%20between%20PWH%20who%20have%20a%20mental%20health%20disorder%20and%20PWH%20without%20mental%20health%20disorders%20in%20South%20Africa%20%28SA%29%20and%20North%20America%20%28NA%29.%5CnMETHODS%3A%20This%20cohort%20study%20includes%20PWH%20aged%2018%20years%20or%20older%20who%20initiated%20ART%20between%202000%20and%202021%20at%20a%20national%20private-sector%20HIV%20programme%20in%20SA%20and%2013%20programmes%20in%20the%20United%20States%20and%20Canada.%20Mental%20health%20disorders%20were%20diagnosed%20according%20to%20ICD-10%20codes%20F10-F99%2C%20which%20include%20psychotic%20disorders%2C%20bipolar%20disorders%2C%20depression%2C%20anxiety%20and%20substance%20use%20disorders.%20We%20estimated%20life-years%20lost%20%28LYL%29%20associated%20with%20mental%20health%20disorders%2C%20quantifying%20the%20average%20difference%20in%20remaining%20life%20expectancy%20between%20individuals%20diagnosed%20with%20a%20mental%20health%20disorder%20and%20those%20without%20such%20diagnoses.%5CnRESULTS%3A%20The%20study%20included%20119%2C785%20participants%20from%20SA%20%2857.4%25%20female%2C%20median%20age%2039%20years%29%20and%20142%2C044%20from%20NA%20%2885.0%25%20male%2C%20median%20age%2043%20years%29.%20In%20SA%2C%2057%2C999%20%2848.4%25%29%20were%20diagnosed%20with%20a%20mental%20health%20disorder%2C%20compared%20with%2093%2C518%20%2865.8%25%29%20in%20NA.%20In%20SA%2C%20the%20LYL%20associated%20with%20any%20mental%20health%20disorder%20were%203.42%20years%20%2895%25%20CI%202.42-4.28%29%20in%20males%20and%202.95%20years%20%280.67-5.95%29%20in%20females.%20Corresponding%20figures%20for%20NA%20were%204.16%20years%20%283.71-4.59%29%20in%20males%20and%204.64%20years%20%282.93-6.05%29%20in%20females.%20In%20both%20regions%2C%20LYL%20were%20higher%20for%20psychotic%20and%20substance%20use%20disorders%20than%20for%20depression%20and%20anxiety.%20Losses%20were%20primarily%20due%20to%20natural%20deaths%20at%20CD4%20counts%20%5Cu2265200%20cells%5C%2F%5Cu00b5l%2C%20with%20considerable%20contributions%20at%20CD4%20counts%20%26lt%3B200%20cells%5C%2F%5Cu00b5l.%20Unnatural%20causes%20also%20contributed%20to%20the%20loss%20of%20life-years%20in%20males%20from%20SA%20and%20males%20and%20females%20from%20NA.%5CnCONCLUSIONS%3A%20PWH%20affected%20by%20mental%20health%20disorders%20experience%20higher%20mortality%2C%20primarily%20from%20natural%20causes.%20LYL%20were%20associated%20with%20both%20immunosuppression%20and%20higher%20CD4%20levels.%20Improved%20management%20of%20HIV%20and%20physical%20comorbidities%20among%20PWH%20affected%20by%20mental%20health%20disorders%20may%20enhance%20their%20prognosis.%22%2C%22date%22%3A%222025-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.70023%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%2C%22YAE5EUBI%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A36%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22DFDZ7RMR%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gastaldon%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BGastaldon%2C%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWhitesell%20Skrivankova%2C%20V.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchoretsanitis%2C%20G.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTaghavi%2C%20K.%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Diagnosis%20of%20postpartum%20depression%20and%20associated%20factors%20in%20South%20Africa%3A%20a%20cohort%20study%20of%2047%2C697%20women.%20%26lt%3Bi%26gt%3BEpidemiology%20and%20Psychiatric%20Sciences%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B34%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e41.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796025100103%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1017%5C%2FS2045796025100103%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diagnosis%20of%20postpartum%20depression%20and%20associated%20factors%20in%20South%20Africa%3A%20a%20cohort%20study%20of%2047%2C697%20women%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Gastaldon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22V.%22%2C%22lastName%22%3A%22Whitesell%20Skrivankova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Schoretsanitis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Taghavi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20A.%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Cornell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Salanti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Mesa%20Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22AIMS%3A%20About%20one-third%20of%20South%20African%20women%20have%20clinically%20significant%20symptoms%20of%20postpartum%20depression%20%28PPD%29.%20Several%20socio-demographic%20risk%20factors%20for%20PPD%20exist%2C%20but%20data%20on%20medical%20and%20obstetric%20risk%20factors%20remain%20scarce%20for%20low-%20and%20middle-income%20countries%20and%20particularly%20in%20sub-Saharan%20Africa.%20We%20aimed%20to%20estimate%20the%20proportion%20of%20women%20with%20PPD%20and%20investigate%20socio-demographic%2C%20medical%20and%20obstetric%20risk%20factors%20for%20PPD%20among%20women%20receiving%20private%20medical%20care%20in%20South%20Africa%20%28SA%29.%5CnMETHODS%3A%20In%20this%20longitudinal%20cohort%20study%2C%20we%20analysed%20reimbursement%20claims%20from%20beneficiaries%20of%20an%20SA%20medical%20insurance%20scheme%20who%20delivered%20a%20child%20between%202011%20and%202020.%20PPD%20was%20defined%20as%20a%20new%20International%20Classification%20of%20Diseases%2C%2010th%20Revision%20diagnosis%20of%20depression%20within%20365%5Cu00a0days%20postpartum.%20We%20estimated%20the%20frequency%20of%20women%20with%20a%20diagnosis%20of%20PPD.%20We%20explored%20several%20medical%20and%20obstetric%20risk%20factors%20for%20PPD%2C%20including%20pre-existing%20conditions%2C%20such%20as%20HIV%20and%20polycystic%20ovary%20syndrome%2C%20and%20conditions%20diagnosed%20during%20pregnancy%20and%20labour%2C%20such%20as%20gestational%20diabetes%2C%20pre-term%20delivery%20and%20postpartum%20haemorrhage.%20Using%20a%20multivariable%20modified%20Poisson%20model%2C%20we%20estimated%20adjusted%20risk%20ratios%20%28aRRs%29%20and%2095%25%20confidence%20intervals%20%28CIs%29%20for%20factors%20associated%20with%20PPD.%5CnRESULTS%3A%20Of%20the%2047%2C697%20participants%2C%202%2C380%20%285.0%25%29%20were%20diagnosed%20with%20PPD.%20The%20cumulative%20incidence%20of%20PPD%20increased%20from%200.8%25%20%2895%25%20CI%200.7-0.9%29%20at%206%20weeks%20to%205.5%25%20%285.3-5.7%29%20at%2012%5Cu00a0months%20postpartum.%20PPD%20risk%20was%20higher%20in%20individuals%20with%20history%20of%20depression%20%28aRR%203.47%2C%2095%25%20CI%20%5B3.14-3.85%5D%29%2C%20preterm%20delivery%20%281.47%20%5B1.30-1.66%5D%29%2C%20PCOS%20%281.37%20%5B1.09-1.72%5D%29%2C%20hyperemesis%20gravidarum%20%281.32%20%5B1.11-1.57%5D%29%2C%20gestational%20hypertension%20%281.30%20%5B1.03-1.66%5D%29%20and%20postpartum%20haemorrhage%20%281.29%20%5B0.91-1.85%5D%29.%20Endometriosis%2C%20HIV%2C%20gestational%20diabetes%2C%20foetal%20stress%2C%20perineal%20laceration%2C%20elective%20or%20emergency%20C-section%20and%20preeclampsia%20were%20not%20associated%20with%20a%20higher%20risk%20of%20PPD.%5CnCONCLUSIONS%3A%20The%20PPD%20diagnosis%20rate%20was%20lower%20than%20anticipated%2C%20based%20on%20the%20PPD%20prevalence%20of%20previous%20studies%2C%20indicating%20a%20potential%20diagnostic%20gap%20in%20SA%26%23039%3Bs%20private%20sector.%20Identified%20risk%20factors%20could%20inform%20targeted%20PPD%20screening%20strategies.%22%2C%22date%22%3A%222025-07-29%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1017%5C%2FS2045796025100103%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222045-7979%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-01T11%3A40%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22C2TMM3CP%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fern%5Cu00e1ndez%20Villalobos%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFern%26%23xE1%3Bndez%20Villalobos%2C%20Nathalie%20Ver%26%23xF3%3Bnica%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHelfenstein%2C%20Fabrice%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKhol%2C%20Vohith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTwizere%2C%20Christella%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSecco%2C%20Mayara%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%20Suppl%203%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20e26477.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26477%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Scale%20of%20differentiated%20service%20delivery%20implementation%20in%20HIV%20care%20facilities%20in%20low-%20and%20middle-income%20countries%3A%20a%20global%20facility%20survey%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Ver%5Cu00f3nica%22%2C%22lastName%22%3A%22Fern%5Cu00e1ndez%20Villalobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Helfenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vohith%22%2C%22lastName%22%3A%22Khol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christella%22%2C%22lastName%22%3A%22Twizere%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mayara%22%2C%22lastName%22%3A%22Secco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Castelnuovo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thierry%22%2C%22lastName%22%3A%22Tiendredbeogo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%20William%22%2C%22lastName%22%3A%22Wester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Siew%20Moy%22%2C%22lastName%22%3A%22Fong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yanink%22%2C%22lastName%22%3A%22Caro-Vega%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%20Elias%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovinio%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Djimon%20Marcel%22%2C%22lastName%22%3A%22Zannou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathy%22%2C%22lastName%22%3A%22Petoumenos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambou%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%20Bolton%22%2C%22lastName%22%3A%22Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ounoo%20Elom%22%2C%22lastName%22%3A%22Takassi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sasisopin%22%2C%22lastName%22%3A%22Kiertiburanakul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rogers%20Ajeh%22%2C%22lastName%22%3A%22Awoh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shamim%20M.%22%2C%22lastName%22%3A%22Ali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffrey%22%2C%22lastName%22%3A%22Fatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Zaniewski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20In%202016%2C%20the%20World%20Health%20Organization%20recommended%20differentiated%20service%20delivery%20%28DSD%29%20as%20a%20client-centred%20approach%20to%20simplify%20HIV%20care%20in%20frequency%20and%20intensity%2C%20thus%20reducing%20the%20clinic%20visit%20burden%20on%20individuals%20and%20HIV%20programmes.%20We%20describe%20the%20scale%20of%20DSD%20implementation%20among%20HIV%20facilities%20in%20low-%20and%20middle-income%20countries%20%28LMICs%29%20in%20Latin%20America%2C%20Africa%20and%20the%20Asia-Pacific%20before%20the%20COVID-19%20pandemic.%5CnMETHODS%3A%20We%20analysed%20facility-level%20survey%20data%20from%20HIV%20care%20facilities%20participating%20in%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20in%202019.%20We%20used%20descriptive%20statistics%20to%20summarise%20the%20availability%20of%20DSD%2C%20multi-month%20dispensing%20%28MMD%29%20and%20DSD%20for%20HIV%20treatment%20models.%20We%20explored%20factors%20associated%20with%20DSD%20implementation%20using%20multivariable%20models.%5CnRESULTS%3A%20We%20included%20175%20facilities%20in%20the%20Asia-Pacific%20%28n%20%3D%2030%29%2C%20Latin%20America%20%28n%20%3D%208%29%2C%20Central%20Africa%20%28n%20%3D%2021%29%2C%20East%20Africa%20%28n%20%3D%2074%29%2C%20Southern%20Africa%20%28n%20%3D%2028%29%20and%20West%20Africa%20%28n%20%3D%2014%29.%20Overall%2C%20133%20facilities%20%2876%25%29%20reported%20implementing%20DSD.%20Of%20these%2C%2091%25%20offered%20DSD%20for%20HIV%20treatment%2C%2061%25%20for%20HIV%20testing%20and%2059%25%20for%20antiretroviral%20therapy%20%28ART%29%20initiation.%20The%20most%20common%20duration%20of%20ART%20refills%20for%20clinically%20stable%20clients%20was%203MMD%2C%20%2870%25%29%2C%20followed%20by%20monthly%20%2814%25%29%20and%206MMD%20%2810%25%29.%20Facility-based%20individual%20models%20were%20the%20most%20frequently%20available%20DSD%20for%20the%20HIV%20treatment%20model%20%2882%25%29%2C%20followed%20by%20client-managed%20group%20models%20%2860%25%29.%20Out-of-facility%20individual%20models%20were%20available%20at%2048%25%20of%20facilities.%20Facility-based%20individual%20models%20were%20particularly%20common%20among%20facilities%20in%20East%20%2892%25%29%20and%20Southern%20Africa%20%2896%25%29.%20Facilities%20in%20medium%20and%20high%20HIV%20prevalence%20countries%2C%20and%20those%20with%203MMD%2C%20were%20more%20likely%20to%20implement%20DSD.%5CnCONCLUSIONS%3A%20In%202019%2C%20DSD%20was%20available%20in%20most%20HIV%20care%20facilities%20globally%20but%20was%20not%20evenly%20implemented%20across%20regions%20and%20HIV%20services.%20Most%20offered%20facility-based%20DSD%20for%20HIV%20treatment%20models%20and%203MMD%20for%20clinically%20stable%20clients.%20Efforts%20to%20expand%20DSD%20for%20HIV%20testing%20and%20ART%20initiation%20and%20to%20offer%20longer%20MMD%20can%20improve%20long-term%20retention%20in%20care%20of%20people%20living%20with%20HIV%20in%20LMICs%2C%20while%20further%20alleviating%20the%20operational%20burden%20on%20healthcare%20services.%20These%20findings%20from%20the%20pre-COVID-19%20era%20underline%20the%20need%20for%20strengthening%20DSD%20in%20HIV%20care%2C%20which%20remains%20at%20the%20centre%20of%20current%20efforts%20towards%20client-centred%20care.%22%2C%22date%22%3A%222025-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26477%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-09-30T14%3A34%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22QC4E5AK2%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiddelkoop%2C%20Keren%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeukes%2C%20Juane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BZ%26%23xFC%3Brcher%2C%20Kathrin%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Infection%20prevention%20and%20control%20measures%20during%20the%20COVID-19%20pandemic%20and%20airborne%20tuberculosis%20transmission%20during%20primary%20care%20visits%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Infectious%20Diseases%3A%20IJID%3A%20Official%20Publication%20of%20the%20International%20Society%20for%20Infectious%20Diseases%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B156%26lt%3B%5C%2Fi%26gt%3B%2C%20S.%20107921.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.107921%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ijid.2025.107921%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Infection%20prevention%20and%20control%20measures%20during%20the%20COVID-19%20pandemic%20and%20airborne%20tuberculosis%20transmission%20during%20primary%20care%20visits%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keren%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juane%22%2C%22lastName%22%3A%22Leukes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Z%5Cu00fcrcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Tuberculosis%20%28TB%29%20transmission%20in%20crowded%20health%20care%20settings%20poses%20considerable%20risks%20in%20high-burden%20regions.%20We%20assessed%20how%20COVID-19%20pandemic-related%20infection%20prevention%20and%20control%20%28IPC%29%20measures%20might%20impact%20TB%20transmission%20in%20a%20South%20African%20primary%20care%20clinic.%5CnMETHODS%3A%20In%202019%20%28prepandemic%29%20and%202021%20%28pandemic%29%2C%20we%20collected%20clinical%20data%2C%20patient%20tracking%20data%20%28person-time%20and%20spatial%20density%29%2C%20indoor%20CO2%20levels%2C%20and%20concentrations%20of%20Mycobacterium%20tuberculosis%20%28Mtb%29%20DNA%20in%20bio-aerosol%20samples.%20We%20estimated%20the%20risk%20of%20Mtb%20transmission%20during%20a%201-hour%20visit%20based%20on%20ventilation%20rate%20and%20duration%20of%20exposure.%5CnRESULTS%3A%20During%20the%20pandemic%2C%20clinics%20were%20less%20crowded%2C%20with%20lower%20mean%20person-time%20per%20day%20%28209%20vs%20258%20hours%3B%20P%20%26lt%3B%200.001%29.%20TB%20prevalence%20among%20patients%20also%20declined%20%281.1%25%20vs%204.7%25%3B%20P%20%3D%200.052%29.%20Environmental%20indicators%20suggested%20improved%20air%20quality%2C%20with%20lower%20CO%5Cu2082%20levels%20%28555%20vs%20856%20parts-per-million%3B%20P%20%26lt%3B%200.001%29%20and%20higher%20ventilation%20rates%20%2815.8%20vs%206.3%20air%20changes%20per%20hour%3B%20P%20%26lt%3B%200.001%29.%20These%20changes%20corresponded%20with%20a%20reduction%20in%20modeled%20Mtb%20transmission%20risk%20%280.04%25%20vs%201.36%25%3B%20P%20%3D%200.046%29.%20Airborne%20Mtb%20DNA%20was%20detected%20in%20both%20periods.%5CnCONCLUSION%3A%20Pandemic-related%20IPC%20measures%20to%20control%20COVID-19%20transmission%20were%20rigorously%20implemented%20and%20likely%20reduced%20transmission%20of%20airborne%20respiratory%20infections%2C%20supporting%20their%20continued%20implementation%20in%20healthcare%20settings%20postpandemic.%22%2C%22date%22%3A%222025-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ijid.2025.107921%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-3511%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A52%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22ZDQLEHPI%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-14%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20Gabriela%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDavies%2C%20Mary-Ann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChinogurei%2C%20Chido%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Association%20between%20changes%20in%20script%20renewal%20periods%20and%20HIV%20viral%20non-suppression%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20program.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003697%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003697%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20changes%20in%20script%20renewal%20periods%20and%20HIV%20viral%20non-suppression%3A%20a%20cohort%20study%20of%20a%20South%20African%20private-sector%20HIV%20program%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chido%22%2C%22lastName%22%3A%22Chinogurei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Evidence%20is%20needed%20to%20inform%20differentiated%20service%20delivery%20models%20for%20people%20with%20HIV%20%28PWH%29.%20During%20the%20COVID-19%20pandemic%2C%20South%20Africa%20temporarily%20changed%20the%20validity%20of%20repeat%20prescriptions%20for%20ART%20from%206%20to%2012%20months.%20We%20evaluated%20the%20association%20between%20these%20changes%20and%20HIV%20viral%20non-suppression%20in%20the%20private%20health%20sector.%5CnMETHODS%3A%20We%20analysed%20routine%20claims%20data%20from%20a%20large%20private-sector%20HIV%20management%20programme.%20PWH%20aged%20%26gt%3B15%20years%20from%204%20months%20after%20first%20ART%20evidence%20were%20included.%20We%20conducted%20an%20interrupted%20time-series%20analysis%20comparing%20trends%20in%20the%20proportions%20of%20PWH%20with%20viral%20non-suppression%20%28viral%20load%20%5Cu226550%20copies%5C%2FmL%29%20during%20three%20periods%3A%20January%201%2C%202019%20to%20April%2023%2C%202020%20%28conventional%206-monthly%20script%20renewal%29%3B%20April%2024%2C%202020%20to%20September%2025%2C%202021%20%2812-monthly%20renewal%29%3B%20and%20September%2026%2C%202021%20to%20November%2030%2C%202022%20%286-monthly%20renewal%20re-instated%29.%20We%20used%20weighting%20to%20maintain%20the%20age%2C%20sex%2C%20ART%20regimen%20and%20medical%20scheme%20distributions%20of%20our%20study%20population%20over%20time.%5CnRESULTS%3A%20Monthly%20odds%20of%20viral%20non-suppression%20initially%20decreased%20by%204%25%20per%20annum%20%28adjusted%20odds%20ratio%20%28aOR%29%200.96%2C%2095%25%20confidence%20interval%20%28CI%29%200.93-0.99%29.%20During%2012-monthly%20renewal%2C%20there%20were%20steeper%20declines%20of%2011%25%20per%20annum%20%28aOR%200.89%2C%2095%25%20CI%200.87-0.91%29.%20After%206-monthly%20renewal%20was%20re-introduced%2C%20viral%20non-suppression%20instead%20increased%20by%206%25%20per%20annum%20%28aOR%201.06%2095%25%20CI%201.03-1.09%29.%20Changes%20in%20slopes%20were%20significant%20%28p-values%20%26lt%3B0.001%29.%5CnCONCLUSION%3A%20Measures%20implemented%20during%20COVID-19%20to%20ensure%20continued%20access%20to%20chronic%20medication%20provided%20unique%20evidence%20for%20models%20involving%20less%20frequent%20clinical%20visits.%20Extending%20prescription%20renewal%20periods%20was%20not%20associated%20with%20worse%20virologic%20outcomes%20among%20privately-insured%20PWH.%22%2C%22date%22%3A%222025-05-14%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003697%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221944-7884%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A53%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22Z4MLM4QG%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFrigati%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20High%20Incidence%20of%20Tuberculosis%20in%20Young%20Children%20Living%20With%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BJournal%20of%20Acquired%20Immune%20Deficiency%20Syndromes%20%281999%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B98%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20S.%20506%26%23x2013%3B514.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003591%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAI.0000000000003591%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22High%20Incidence%20of%20Tuberculosis%20in%20Young%20Children%20Living%20With%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariette%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Data%20on%20tuberculosis%20%28TB%29%20incidence%20and%20risk%20factors%20among%20children%20living%20with%20HIV%20%28CLHIV%29%20in%20the%20universal%20ART%20era%20are%20limited.%5CnMETHODS%3A%20We%20analyzed%20routinely%20collected%20data%20on%20TB%20diagnoses%20for%20CLHIV%20age%20%5Cu22645%20years%2C%20born%202018-2022%2C%20in%20the%20Westen%20Cape%2C%20South%20Africa.%20We%20examined%20factors%20associated%20with%20TB%20diagnosis%2C%20with%20death%20and%20loss%20to%20follow-up%20as%20competing%20events.%5CnRESULTS%3A%20Among%202219%20CLHIV%2C%2030%25%20were%20diagnosed%20with%20HIV%20at%20birth.%20Median%20follow-up%20from%20birth%20was%2038%20months%20%5Binterquartile%20range%20%28IQR%3A%2024-50%29%3B%2090%25%20started%20antiretroviral%20therapy%20%28ART%29.%20TB%20was%20diagnosed%20in%2028%25%20of%20CLHIV%20%28n%20%3D%20626%5C%2F2219%29%3B%2062%25%20were%20first%20diagnosed%20before%5C%2Fwithin%203%20months%20of%20ART%20start%20%28%26quot%3BTB%20before%20ART%26quot%3B%29%20and%2038%25%20%26gt%3B3%20months%20after%20ART%20start%20%28%26quot%3BTB%20after%20ART%26quot%3B%29.%20Of%20those%20with%20%26quot%3BTB%20before%20ART%26quot%3B%20%28n%20%3D%20390%29%2C%20median%20age%20at%20HIV%20diagnosis%20was%2013%20months%20%28IQR%3A%206-22%29%3B%20median%20time%20between%20HIV%20and%20TB%20diagnoses%20was%205%20days%20%28IQR%3A%200-31%29.%20%26quot%3BTB%20before%20ART%26quot%3B%20was%20associated%20with%20older%20age%20at%20HIV%20diagnosis%20and%20advanced%5C%2Fsevere%20immunodeficiency.%20Of%20those%20with%20%26quot%3BTB%20after%20ART%26quot%3B%20%28n%20%3D%20258%29%2C%20median%20age%20at%20HIV%20diagnosis%20was%202%20months%20%28IQR%3A%200-8%29%20and%20median%20time%20from%20ART%20start%20to%20TB%20diagnosis%20was%2012%20months%20%28IQR%3A%207-21%29.%20%26quot%3BTB%20after%20ART%26quot%3B%20was%20associated%20with%20increased%20viral%20load%20and%20advanced%5C%2Fsevere%20immunosuppression%20%28time%20updated%29.%20Overall%2C%205%25%20%28n%20%3D%20112%5C%2F2219%29%20of%20CLHIV%20died%2C%2036%25%20of%20whom%20were%20diagnosed%20with%20TB%20%28median%20time%20from%20TB%20diagnosis%20to%20death%3A%2058%20days%3B%20IQR%3A%2017-191%29.%5CnCONCLUSIONS%3A%20Young%20CLHIV%20in%20this%20setting%20have%20high%20TB-associated%20morbidity%20and%20mortality.%20Efforts%20to%20improve%20early%20HIV%20and%20TB%20diagnosis%2C%20viral%20suppression%2C%20and%20TB%20preventive%20therapy%20are%20needed.%22%2C%22date%22%3A%222025-04-15%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAI.0000000000003591%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221944-7884%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-08-05T13%3A53%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22BS29FRDB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Patten%20et%20al.%22%2C%22parsedDate%22%3A%222025-04-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPatten%2C%20Gabriela%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMalateste%2C%20Karen%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBolton%20Moore%2C%20Carolyn%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSipambo%2C%20Nosisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMokone%2C%20Limpho%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV.%20%26lt%3Bi%26gt%3BThe%20Pediatric%20Infectious%20Disease%20Journal%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FINF.0000000000004819%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20Trends%20in%20CD4%20Measurement%20and%20Immunosuppression%20at%20ART%20Initiation%20Among%20Children%20With%20HIV%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriela%22%2C%22lastName%22%3A%22Patten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Malateste%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%20Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nosisa%22%2C%22lastName%22%3A%22Sipambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Limpho%22%2C%22lastName%22%3A%22Mokone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nanina%22%2C%22lastName%22%3A%22Anderegg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kara%22%2C%22lastName%22%3A%22Wools-Kaloustian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%22%2C%22lastName%22%3A%22Odhiambo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Kasozi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Desmonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dewi%22%2C%22lastName%22%3A%22Kumara%20Wati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Revathy%22%2C%22lastName%22%3A%22Nallusamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aarti%22%2C%22lastName%22%3A%22Kinikar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Du%20Tuan%22%2C%22lastName%22%3A%22Quy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20Vanes%22%2C%22lastName%22%3A%22Ebasone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jorge%22%2C%22lastName%22%3A%22Pinto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nel%20Jason%22%2C%22lastName%22%3A%22Haw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20collaboration%22%7D%5D%2C%22abstractNote%22%3A%22Eligibility%20for%20antiretroviral%20therapy%20is%20no%20longer%20based%20on%20immune%20criteria.%20In%20a%20global%20cohort%20of%2097%2C453%20children%2C%20between%202005%20and%202021%2C%20we%20observed%20large%20declines%20in%20CD4%20measurement%2C%20from%2051%25%20to%2012%25%20among%20%26lt%3B5%20seconds%2C%20and%20from%2074%25%20to%2020%25%20among%20those%205-14%20years%20of%20age.%20Lack%20of%20CD4%20testing%20may%20negatively%20affect%20clinical%20care%20and%20surveillance%20of%20severe%20immune%20suppression.%22%2C%22date%22%3A%222025-04-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FINF.0000000000004819%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221532-0987%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A36%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22CGJDXP9C%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Embleton%20et%20al.%22%2C%22parsedDate%22%3A%222025-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEmbleton%2C%20Lonnie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSudjaritruk%2C%20Tavitiya%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMachado%2C%20Daisy%20Maria%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMusabyimana%2C%20Fran%26%23xE7%3Boise%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e26437.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26437%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Characterizing%20adolescent%20and%20youth-friendly%20HIV%20services%3A%20a%20cross-sectional%20assessment%20across%2016%20global%20sites%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lonnie%22%2C%22lastName%22%3A%22Embleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tavitiya%22%2C%22lastName%22%3A%22Sudjaritruk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daisy%20Maria%22%2C%22lastName%22%3A%22Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7oise%22%2C%22lastName%22%3A%22Musabyimana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Jesson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edith%22%2C%22lastName%22%3A%22Apondi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thanyawee%22%2C%22lastName%22%3A%22Puthanakit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%20Tulio%22%2C%22lastName%22%3A%22Luque%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%20Ellen%22%2C%22lastName%22%3A%22van%20Dongen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gad%22%2C%22lastName%22%3A%22Murenzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Madeleine%22%2C%22lastName%22%3A%22Amorissani-Folquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zachary%22%2C%22lastName%22%3A%22Kwena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Perreras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Rouzier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rita%22%2C%22lastName%22%3A%22Lyamuya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Batya%22%2C%22lastName%22%3A%22Elul%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Val%5Cu00e9riane%22%2C%22lastName%22%3A%22Leroy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leslie%20A.%22%2C%22lastName%22%3A%22Enane%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roxanne%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathryn%22%2C%22lastName%22%3A%22Lancaster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%20M.%22%2C%22lastName%22%3A%22Parcesepe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Vreeman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Adolescent%20and%20youth-friendly%20health%20services%20%28AYFHS%29%20have%20been%20promoted%20as%20a%20best%20practice%20for%20adolescents%20and%20young%20people%20living%20with%20HIV%20%28AYLH%29.%20However%2C%20thorough%20descriptions%20of%20AYFHS%20for%20AYLH%20remain%20scarce.%20We%20sought%20to%20characterize%20adolescent-friendly%20HIV%20services%20in%20a%20global%20paediatric%20research%20consortium.%5CnMETHODS%3A%20Cross-sectional%20data%20were%20collected%20from%2016%20global%20sites%20in%20the%20Adolescent%20and%20Young%20Adult%20Network%20of%20IeDEA%20%28AYANI%29%20of%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20consortium%20between%20August%202020%20and%20October%202022%20using%20a%20standardized%20site%20assessment%20tool%20that%20collected%20data%20on%20clinic%2C%20patient%20and%20provider%20characteristics%2C%20differentiated%20care%2C%20and%20transition%20to%20adult%20services%20processes.%20Descriptive%20analyses%20characterized%20the%20health%20services%20available%20across%20the%20participating%20sites%2C%20using%20frequencies%20and%20proportions%20for%20categorical%20variables%20and%20medians%20and%20interquartile%20range%20for%20continuous%20variables.%20Data%20were%20analysed%20using%20RStudio.%5CnRESULTS%3A%20Overall%2C%2013%20of%2016%20sites%20%2881%25%29%20reported%20having%20dedicated%20adolescent%20services%2C%20which%20most%20often%20consisted%20of%20dedicated%20clinic%20days%20%2862%25%2C%20n%20%3D%208%5C%2F13%29%2C%20primarily%20offered%20on%20weekdays.%20Across%20all%20sites%2C%20nurses%20and%20counsellors%20delivered%20services%20to%20adolescents.%20Over%20half%20of%20all%20clinics%20%2869%25%2C%20n%20%3D%2011%5C%2F16%29%20reported%20offering%20health%20education%20to%20adolescents%20to%20facilitate%20adolescent%20health%20literacy.%20Peer%20educators%20and%20navigators%20were%20involved%20in%20delivering%20services%20at%2062%25%20of%20sites%2C%20primarily%20in%20those%20with%20dedicated%20adolescent%20services%20%2869%25%2C%20n%20%3D%209%5C%2F13%29.%20There%20was%20limited%20integration%20of%20sexual%20and%20reproductive%20health%20services%20into%20HIV%20clinics%20for%20adolescents.%20With%2063%25%20of%20clinics%20conducting%20pregnancy%20screening%2C%2050%25%20providing%20family%20planning%20methods%20and%2038%25%20providing%20cervical%20cancer%20screening.%20Under%20half%20of%20all%20HIV%20clinics%20screened%20for%20physical%20abuse%20or%20violence%20%2844%25%2C%20n%20%3D%207%5C%2F16%29%20and%20sexual%20abuse%20or%20rape%20%2838%25%2C%20n%20%3D%206%5C%2F16%29.%20A%20low%20proportion%20of%20clinics%20screened%20for%20risk%20factors%20related%20to%20young%20key%20populations%2C%20including%20drug%20use%20%2856%25%2C%20n%20%3D%209%5C%2F16%29%2C%20homelessness%20%2838%25%2C%20n%20%3D%206%5C%2F16%29%20young%20men%20having%20sex%20with%20men%20%2831%25%2C%20n%20%3D%205%5C%2F16%29%20and%20transactional%20sex%20%2831%25%2C%20n%20%3D%205%5C%2F16%29.%20Mental%20health%20screening%20for%20concerns%20was%20variable.%5CnCONCLUSIONS%3A%20Findings%20suggest%20gaps%20in%20AYFHS%20for%20AYLH%20across%20the%20HIV%20clinics%20included%20in%20this%20analysis.%20There%20is%20a%20vital%20need%20to%20design%20health%20services%20for%20AYLH%20that%20are%20accessible%2C%20equitable%2C%20and%20effective%20and%20meet%20the%20global%20standards%20for%20delivering%20high-quality%20healthcare%20to%20adolescents.%22%2C%22date%22%3A%222025-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26437%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-08-05T13%3A54%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22JVIGBFUD%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ballif%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBallif%2C%20Marie%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BPerrig%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAvihingsanon%2C%20Anchalee%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNsonde%2C%20Dominique%20Mahambu%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa.%20%26lt%3Bi%26gt%3BBMJ%20Global%20Health%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B10%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e017828.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjgh-2024-017828%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20long-term%20impact%20of%20the%20COVID-19%20pandemic%20on%20tuberculosis%20care%20and%20infection%20control%20measures%20in%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20low-%20and%20middle-income%20countries%3A%20a%20multiregional%20site%20survey%20in%20Asia%20and%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Ballif%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anchalee%22%2C%22lastName%22%3A%22Avihingsanon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominique%20Mahambu%22%2C%22lastName%22%3A%22Nsonde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Obatsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Komena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haruka%22%2C%22lastName%22%3A%22Uemura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Lelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%22%2C%22lastName%22%3A%22Otaalo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacqueline%22%2C%22lastName%22%3A%22Huwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrice%22%2C%22lastName%22%3A%22Gou%5Cu00e9ss%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nagalingeswaran%22%2C%22lastName%22%3A%22Kumarasamy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Brazier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denna%22%2C%22lastName%22%3A%22Michael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Idiovino%22%2C%22lastName%22%3A%22Rafael%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Ramd%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22I.%20Ketut%20Agus%22%2C%22lastName%22%3A%22Somia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Yotebieng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lameck%22%2C%22lastName%22%3A%22Diero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ezechi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Global%20IeDEA%20consortium%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20COVID-19%20pandemic%20challenged%20healthcare%20systems%2C%20particularly%20in%20settings%20with%20high%20infectious%20disease%20burden.%20We%20examined%20the%20postpandemic%20long-term%20impacts%20of%20COVID-19%20on%20tuberculosis%20%28TB%29%20services%20at%20anti-retroviral%20therapy%20%28ART%29%20clinics%20in%20lower-income%20countries.%5CnMETHODS%3A%20Using%20standardised%20online%20questionnaires%2C%20we%20conducted%20a%20cross-sectional%20site%20survey%20among%20ART%20clinics%20providing%20TB%20services%20in%20Africa%20and%20Asia%20from%20July%20to%20September%202023%20%28site-level%20information%20and%20number%20of%20TB%20diagnoses%20and%20tests%29.%5CnRESULTS%3A%20Of%2045%20participating%20ART%20clinics%2C%2032%20%2871%25%29%20were%20in%20Africa%20and%2013%20%2829%25%29%20in%20Asia.%20During%20the%20COVID-19%20pandemic%20%282020-2022%29%2C%2043%20%2896%25%29%20clinics%20reported%20implementing%20social%20distancing%20or%20separation%20measures%2C%2039%20%2887%25%29%20personal%20protections%20for%20staff%20members%20and%2032%20%2871%25%29%20protections%20for%20patients.%20Infection%20control%20measures%20were%20in%20place%20in%2045%25%20of%20the%20clinics%20before%20the%20pandemic%20%28until%202019%29%2C%2023%25%20introduced%20measures%20during%20the%20pandemic%20and%2015%25%20maintained%20them%20after%20the%20pandemic%20%28after%202022%29.%20Service%20provision%20was%20affected%20during%20the%20pandemic%20in%2033%20%2873%25%29%20clinics%2C%20including%20TB%20services%20in%2022%20%2849%25%29%20clinics.%20TB%20service%20restrictions%20were%20addressed%20by%20introducing%20changes%20in%20directly%20observed%20therapy%20provision%20in%208%20%2818%25%29%20clinics%2C%20multimonth%20TB%20drug%20dispensing%20in%2023%20%2851%25%29%2C%20telehealth%20services%20in%2025%20%2856%25%29%20and%20differentiated%20service%20delivery%20in%2019%20%2842%25%29.%20These%20changes%20were%20sustained%20after%20the%20pandemic%20at%204%20%289%25%29%2C%2011%20%2824%25%29%2C%2017%20%2838%25%29%20and%2012%20%2827%25%29%20clinics%2C%20respectively.%20Compared%20with%202018-2019%2C%20the%20number%20of%20TB%20diagnoses%20decreased%20sharply%20in%202020-2021%20and%20improved%20after%20the%20pandemic.%5CnCONCLUSIONS%3A%20COVID-19%20affected%20TB%20care%20services%20in%20ART%20clinics%20in%20Africa%20and%20Asia.%20This%20was%20paralleled%20by%20a%20reduction%20in%20TB%20diagnoses%2C%20which%20partly%20resumed%20after%20the%20pandemic.%20Infection%20control%20measures%20and%20alternative%20modes%20of%20service%20delivery%20were%20adopted%20during%20the%20pandemic%20and%20only%20partially%20maintained.%20Efforts%20should%20be%20made%20to%20sustain%20the%20lessons%20learnt%20during%20the%20COVID-19%20pandemic%2C%20particularly%20approaches%20that%20reduce%20the%20risk%20of%20transmission%20of%20infectious%20diseases%2C%20including%20TB%2C%20in%20ART%20clinics.%22%2C%22date%22%3A%222025-03-24%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjgh-2024-017828%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222059-7908%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-07-08T08%3A12%3A52Z%22%7D%7D%2C%7B%22key%22%3A%224TA3Y9W8%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuloiwa%2C%20Rudzani%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Hospitalisation%20incidence%20among%20young%20children%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa.%20%26lt%3Bi%26gt%3BAIDS%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004156%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FQAD.0000000000004156%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Hospitalisation%20incidence%20among%20young%20children%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudzani%22%2C%22lastName%22%3A%22Muloiwa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20M.%22%2C%22lastName%22%3A%22Le%20Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thandi%22%2C%22lastName%22%3A%22Wessels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jaco%22%2C%22lastName%22%3A%22Murray%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Euvrard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Studies%20examining%20hospitalization%20among%20young%20children%20with%20HIV%20in%20resource-limited%20settings%2C%20in%20the%20context%20of%20early%20infant%20diagnosis%20and%20early%20antiretroviral%20therapy%20%28ART%29%20initiation%2C%20are%20limited.%5CnMETHODS%3A%20We%20used%20routinely%20collected%20data%20to%20describe%20hospitalization%20patterns%20among%20children%20%28age%20%5Cu22645%5Cu200ayears%29%2C%20born%202018-2022%2C%20who%20were%20diagnosed%20with%20HIV%20%28Western%20Cape%20province%2C%20South%20Africa%29.%20We%20used%20mixed-effects%20Poisson%20models%20to%20examine%20factors%20associated%20with%20overall%20hospitalization%20and%20hospitalization%20after%20ART%20initiation.%5CnRESULTS%3A%20We%20included%202219%20children%2C%2030%25%20were%20diagnosed%20with%20HIV%20at%20birth%20%28%5Cu22647%5Cu200adays%29%2C%20an%20additional%2041%25%20before%20age%201%5Cu200ayear%2C%20and%2029%25%20at%20age%20%5Cu22651%5Cu200ayear.%20Median%20follow-up%20from%20birth%20was%2038%5Cu200amonths%20%28interquartile%20range%2024-50%29.%20Overall%2C%2067%25%20of%20children%20were%20hospitalized%2C%20of%20whom%2050%25%20had%20%26gt%3B1%20hospitalization.%20Excluding%20birth%20admissions%2C%2035%25%20of%20children%20were%20hospitalized%20before%20ART%20start%20%28n%5Cu200a%3D%5Cu200a781%5C%2F2219%29.%20Among%20children%20who%20started%20ART%2C%2038%25%20%28n%5Cu200a%3D%5Cu200a747%5C%2F1990%29%20had%20admissions%20after%20ART%20start.%20Compared%20to%20children%20diagnosed%20with%20HIV%20at%20birth%2C%20overall%20hospitalization%20rates%20%28excluding%20birth%20admissions%29%20increased%20by%2067%25%20%5B95%25%20confidence%20interval%20%28CI%29%3A%2039-101%5D%2C%2074%25%20%2895%25%20CI%3A%2045-109%29%20and%2029%25%20%2895%25%20CI%3A%209-51%25%29%20among%20those%20diagnosed%20at%20age%201%5Cu200aweek%20to%203%5Cu200amonths%2C%20%26gt%3B3%20to%209%5Cu200amonths%2C%20and%20%26gt%3B9%5Cu200amonths%2C%20respectively.%20Hospitalization%20rates%20after%20ART%20start%20were%20twice%20as%20high%20%28103%25%20increase%3B%2095%25%20CI%3A%2068-146%25%29%20among%20children%20who%20had%20unsuppressed%20viral%20load%20%28%5Cu22651000%5Cu200acopies%5C%2Fml%29%20at%204%20or%2012%5Cu200amonths%20after%20ART%20start.%5CnCONCLUSIONS%3A%20High%20hospitalization%20rates%20occur%20among%20young%20children%20with%20HIV.%20Earlier%20HIV%20diagnosis%2C%20enabling%20earlier%20ART%20initiation%2C%20is%20associated%20with%20lower%20overall%20hospitalization%20rates.%20Unsuppressed%20viral%20load%20is%20associated%20with%20higher%20post-ART%20hospitalization%20rates.%22%2C%22date%22%3A%222025-03-18%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FQAD.0000000000004156%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221473-5571%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A43%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22HXCBRY88%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schwab%20et%20al.%22%2C%22parsedDate%22%3A%222025-03-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchwab%2C%20Tiana%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJoseph%2C%20Lavania%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMoono%2C%20Andrew%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BG%26%23xF6%3Bller%2C%20Pauline%20C.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMotsei%2C%20Mamello%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Field%20evaluation%20of%20nanopore%20targeted%20next-generation%20sequencing%20to%20predict%20drug-resistant%20tuberculosis%20from%20native%20sputum%20in%20South%20Africa%20and%20Zambia.%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B63%26lt%3B%5C%2Fi%26gt%3B%20%283%29%2C%20S.%20e0139024.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01390-24%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1128%5C%2Fjcm.01390-24%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Field%20evaluation%20of%20nanopore%20targeted%20next-generation%20sequencing%20to%20predict%20drug-resistant%20tuberculosis%20from%20native%20sputum%20in%20South%20Africa%20and%20Zambia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tiana%20C.%22%2C%22lastName%22%3A%22Schwab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lavania%22%2C%22lastName%22%3A%22Joseph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Moono%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pauline%20C.%22%2C%22lastName%22%3A%22G%5Cu00f6ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mamello%22%2C%22lastName%22%3A%22Motsei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Neuenschwander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%20M.%22%2C%22lastName%22%3A%22Keller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alban%22%2C%22lastName%22%3A%22Ramette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaheed%20V.%22%2C%22lastName%22%3A%22Omar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22IeDEA%20Southern%20Africa%20%28IeDEA-SA%29%22%7D%5D%2C%22abstractNote%22%3A%22Rapid%20and%20comprehensive%20drug%20susceptibility%20testing%20%28DST%29%20is%20essential%20for%20diagnosing%20and%20treating%20drug-resistant%20tuberculosis%20effectively%2C%20and%20next-generation%20sequencing%20can%20be%20an%20effective%20genotypic%20DST%20method.%20We%20implemented%20and%20evaluated%20the%20performance%20of%20a%20nanopore%20targeted%20sequencing%20assay%2C%20called%20the%20Tuberculosis%20Drug%20Resistance%20Test%20%28TBDR%2C%20Oxford%20Nanopore%20Diagnostics%2C%20Ltd.%2C%20United%20Kingdom%29%2C%20which%20predicts%20drug%20resistance%20to%2016%20TB%20drugs%2C%20at%20a%20South%20African%20reference%20laboratory%20and%20a%20district%20diagnostic%20laboratory%20in%20Zambia.%20We%20compared%20the%20sequencing%20success%20rates%20between%20unprocessed%20and%20decontaminated%20sputum%20samples%20and%20determined%20the%20diagnostic%20accuracy%20against%20local%20DST%20%28Xpert%20MTB%5C%2FRIF%20Ultra%2C%20Xpert%20MTB%5C%2FXDR%2C%20and%20BD%20BACTEC%20MGIT%20phenotypic%20DST%29.%20We%20prospectively%20sequenced%20236%20samples%20and%20have%20148%20samples%20with%20sequencing%20results%20from%20unprocessed%20and%20decontaminated%20sputum.%20We%20obtained%20successful%20sequencing%20results%20from%2066.4%25%20%2894%5C%2F148%29%20unprocessed%20sputum%20samples%20and%2075%25%20%28111%5C%2F148%29%20decontaminated%20samples.%20Sequencing%20success%20rates%20at%20the%20two%20sites%20differed%2C%20with%2050.7%25%20%2836%5C%2F71%29%20successful%20sequencing%20results%20from%20unprocessed%20sputum%20in%20Zambia%20and%2075.3%25%20%2858%5C%2F77%29%20in%20South%20Africa.%20Samples%20with%20%26quot%3Blow%26quot%3B%20bacterial%20load%2C%20measured%20by%20Xpert%20MTB%5C%2FRIF%20Ultra%2C%20tended%20to%20produce%20fewer%20successful%20sequencing%20results.%20TBDR%20sequencing%20predicted%20resistances%20in%2048%20samples%2C%20detecting%20resistance%20for%20rifampicin%20%28n%20%3D%2041%29%20and%20isoniazid%20%28n%20%3D%2020%29%2C%20as%20well%20as%2010%20second-line%20drugs%20%28n%20%3D%2015%29.%20Sensitivity%20was%20variable%20compared%20to%20phenotypic%20DST%2C%20ranging%20from%2033%20%28ethionamide%29%20to%2094%25%20%28rifampicin%29%2C%20while%20specificity%20remained%20above%2090%25%20for%20all%20drugs%2C%20except%20clofazimine.%20The%20TBDR%20assay%20can%20provide%20rapid%2C%20comprehensive%20genotypic%20DST.%20Technical%20and%20operational%20challenges%20need%20to%20be%20addressed%20for%20its%20broader%20implementation%20in%20high%20tuberculosis-burden%20settings.IMPORTANCEThis%20study%20illustrates%20the%20use%20of%20the%20Tuberculosis%20Drug%20Resistance%20Test%20%28TBDR%2C%20Oxford%20Nanopore%20Diagnostics%2C%20Ltd.%2C%20United%20Kingdom%29%20as%20a%20rapid%20drug%20susceptibility%20testing%20%28DST%29%20approach%20for%20diagnosing%20drug-resistant%20TB%20in%20the%20high%20TB-burden%20countries%20of%20South%20Africa%20and%20Zambia.%20The%20TBDR%20assay%20predicts%20resistance%20to%2016%20TB%20drugs%2C%20including%20first-%20and%20second-line%20treatments.%20By%20implementing%20the%20TBDR%20assay%20in%20a%20national%20reference%20laboratory%20in%20South%20Africa%20and%20a%20district%20diagnostic%20laboratory%20in%20Zambia%2C%20we%20demonstrate%20how%20this%20technology%20can%20provide%20faster%20diagnostic%20results%20%28days%29%20compared%20to%20traditional%20phenotypic%20DST%20methods%20%28~2%20months%29%2C%20with%20adequate%20sensitivity.%20Missed%20resistances%20compared%20to%20phenotypic%20DST%20indicate%20that%20technical%20improvements%20are%20needed.%20Successful%20sequencing%20from%20unprocessed%20and%20decontaminated%20sputum%20samples%20at%20different%20sites%20suggests%20feasibility%20in%20diverse%20settings%2C%20though%20operational%20challenges%20remain.%20Implementing%20this%20rapid%2C%20comprehensive%20DST%20approach%20could%20enhance%20drug-resistant%20tuberculosis%20diagnosis%20and%20treatment%2C%20ultimately%20improving%20patient%20outcomes%20and%20helping%20to%20combat%20tuberculosis%20in%20high-burden%20regions.%22%2C%22date%22%3A%222025-03-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1128%5C%2Fjcm.01390-24%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221098-660X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-03-20T12%3A32%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22FWC57YQB%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Chihota%20et%20al.%22%2C%22parsedDate%22%3A%222025-02-07%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChihota%2C%20Belinda%20Varaidzo%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMandiriri%2C%20Ardele%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanda%2C%20Esau%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BShamu%2C%20Tinei%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Cohort%20profile%3A%20Noncommunicable%20diseases%20and%20ideal%20cardiovascular%20health%20among%20people%20living%20with%20and%20without%20HIV%20in%20Zambia%20and%20Zimbabwe%20%28NCDzz%20cohort%29.%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B15%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e088706.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-088706%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2024-088706%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cohort%20profile%3A%20Noncommunicable%20diseases%20and%20ideal%20cardiovascular%20health%20among%20people%20living%20with%20and%20without%20HIV%20in%20Zambia%20and%20Zimbabwe%20%28NCDzz%20cohort%29.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Belinda%20Varaidzo%22%2C%22lastName%22%3A%22Chihota%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ardele%22%2C%22lastName%22%3A%22Mandiriri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esau%22%2C%22lastName%22%3A%22Banda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tinei%22%2C%22lastName%22%3A%22Shamu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton-Moore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cleophas%22%2C%22lastName%22%3A%22Chimbetete%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Samuel%22%2C%22lastName%22%3A%22Bosomprah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gilles%22%2C%22lastName%22%3A%22Wandeler%22%7D%5D%2C%22abstractNote%22%3A%22PURPOSE%3A%20The%20NCDzz%20study%20is%20a%20prospective%20cohort%20of%20people%20living%20with%20and%20without%20HIV%20attending%20primary%20care%20clinics%20in%20Zambia%20and%20Zimbabwe%20and%20was%20established%20in%202019%20to%20understand%20the%20intersection%20between%20noncommunicable%20diseases%20%28NCDs%29%20and%20HIV%20in%20Southern%20Africa.%20Here%2C%20we%20describe%20the%20study%20design%20and%20population%20and%20evaluate%20their%20ideal%20cardiovascular%20health%20%28ICVH%29%20using%20the%20Life%26%23039%3Bs%20Simple%207%20%28LS7%29%20score%20according%20to%20the%20American%20Heart%20Association.%20PARTICIPANTS%3A%20Antiretroviral%20therapy-naive%20people%20living%20with%20HIV%20%28PLWH%29%20and%20people%20living%20without%20HIV%20%28PLWOH%29%2030%20years%20or%20older%20were%20recruited%20from%20three%20primary%20care%20clinics%20in%20Lusaka%20and%20Harare%2C%20and%20underwent%20comprehensive%20clinical%2C%20laboratory%20and%20behavioural%20assessments.%20All%20study%20measurements%20are%20repeated%20during%20yearly%20follow-up%20visits.%20PLWOH%20were%20recruited%20from%20the%20same%20neighbourhoods%20and%20had%20similar%20socioeconomic%20conditions%20as%20PLWH.%20FINDINGS%20TO%20DATE%3A%20Between%20August%202019%20and%20March%202023%2C%20we%20included%201100%20adults%2C%20of%20whom%20618%20%2856%25%29%20were%20females%20and%20539%20%2849%25%29%20were%20PLWH.%20The%20median%20age%20at%20enrolment%20was%2039%20years%20%28IQR%2034-46%20years%29.%20Among%201013%20participants%20%2892%25%29%20with%20complete%20data%2C%20the%20median%20LS7%20score%20was%2011%5C%2F14%20%28IQR%2010-12%29.%20Overall%2C%2060%25%20of%20participants%20met%20the%20criteria%20of%20ICVH%20metrics%20%285-7%20ideal%20components%29%20and%20among%20individual%20components%20of%20the%20LS7%2C%20more%20females%20had%20poor%20body%20mass%20index%20%28BMI%29%20than%20males%2C%20regardless%20of%20HIV%20status%20%2827%25%20vs%203%25%2C%20p%26lt%3B0.001%29.%20Our%20data%20show%20no%20apparent%20difference%20in%20cardiovascular%20health%20determinants%20between%20men%20and%20women%2C%20but%20high%20BMI%20in%20women%20and%20overall%20high%20hypertension%20prevalence%20need%20detailed%20investigation.%20Untreated%20HIV%20%28OR%3A%201.36%20%28IQR%201.05-1.78%29%29%20and%20being%20a%20Zambian%20participant%20%28OR%3A%201.81%20%28IQR%201.31-2.51%29%29%20were%20associated%20with%20having%20ICVH%20metrics%2C%20whereas%20age%20older%20than%2050%20years%20%28OR%3A%200.46%20%28IQR%200.32-0.65%29%29%20was%20associated%20with%20not%20having%20ICVH%20metrics.%20FUTURE%20PLANS%3A%20Our%20study%20will%20be%20regularly%20updated%20with%20upcoming%20analyses%20using%20prospective%20data%20including%20a%20focus%20on%20arterial%20hypertension%20and%20vascular%20function.%20We%20plan%20to%20enrich%20the%20work%20through%20conducting%20in-depth%20assessments%20on%20the%20determinants%20of%20cardiovascular%2C%20liver%20and%20kidney%20end-organ%20disease%20outcomes%20yearly.%20Additionally%2C%20we%20seek%20to%20pilot%20NCD%20interventions%20using%20novel%20methodologies%20like%20the%20trials%20within%20cohorts.%20Beyond%20the%20initial%20funding%20support%2C%20we%20aim%20to%20collect%20at%20minimum%20yearly%20data%20for%20an%20additional%205-year%20period.%22%2C%22date%22%3A%222025%20Feb%207%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2024-088706%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222044-6055%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A56Z%22%7D%7D%2C%7B%22key%22%3A%224H6RFYTE%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ford%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A7%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFord%2C%20Nathan%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKassanjee%2C%20Reshma%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BStelzle%2C%20Dominik%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BJarvis%2C%20Joseph%20N.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSued%2C%20Omar%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26415.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26415%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Global%20prevalence%20of%20advanced%20HIV%20disease%20in%20healthcare%20settings%3A%20a%20rapid%20review.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Ford%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Stelzle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joseph%20N.%22%2C%22lastName%22%3A%22Jarvis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omar%22%2C%22lastName%22%3A%22Sued%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georges%22%2C%22lastName%22%3A%22Perrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meg%22%2C%22lastName%22%3A%22Doherty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajay%22%2C%22lastName%22%3A%22Rangaraj%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Recent%20studies%20have%20indicated%20a%20high%20enduring%20burden%20of%20advanced%20HIV%20disease%2C%20but%20estimates%20across%20regions%20and%20settings%20are%20lacking.%20The%20aim%20of%20this%20study%20was%20to%20estimate%20the%20prevalence%20of%20advanced%20HIV%20disease%20since%202015%20among%20those%20people%20with%20CD4%20measured%20in%20healthcare%20settings%2C%20disaggregated%20by%20age%20group%2C%20level%20of%20healthcare%20and%20region.%20METHODS%3A%20We%20searched%20MedLine%20via%20Pubmed%20and%20Hinari%20for%20studies%20that%20reported%20the%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20%28defined%20as%20CD4%20cell%20count%20%26lt%3B200%20cells%5C%2Fmm%283%29%29%20in%20healthcare%20settings%20since%202015%3B%20this%20search%20was%20complemented%20by%20conference%20abstracts%20and%20data%20from%20the%20International%20epidemiology%20Databases%20to%20Evaluate%20AIDS%20Consortium%20%28IeDEA%29.%20We%20estimated%20pooled%20prevalence%20of%20advanced%20HIV%20disease%20using%20random-%20effects%20models%20and%20performed%20subgroup%20and%20sensitivity%20analyses%20to%20explore%20heterogeneity.%20RESULTS%3A%20We%20obtained%20data%20from%20117%20cohorts%2C%20representing%201%2C814%2C362%20individuals%20from%2052%20countries%20across%20all%20six%20World%20Health%20Organization%20regions.%20The%20majority%20of%20studies%20%28n%20%3D%2083%29%20were%20conducted%20among%20adults%20and%20recorded%20CD4%20cell%20count%20among%20treatment%20naive%20individuals%20at%20antiretroviral%20therapy%20start%20%28n%20%3D%2086%29.%20Studies%20included%20data%20reported%20up%20to%202023.%20The%20proportion%20of%20individuals%20with%20advanced%20HIV%20disease%20was%20higher%20in%20inpatient%20settings%20%2844.3%25%2C%2095%25%20CI%2039.1-49.6%25%29%20compared%20to%20outpatient%20settings%20%2833.5%25%2C%2095%25%20CI%2031.5-35.4%25%29.%20Prevalence%20was%20similar%20across%20age%20groups%2C%20time%20since%20HIV%20diagnosis%20and%20treatment%20status%2C%20and%20highest%20in%20West%20and%20Central%20Africa%2C%20South-East%20Asia%20and%20the%20Eastern%20Mediterranean%20region.%20DISCUSSION%3A%20This%20review%20finds%20that%20at%20least%20a%20third%20of%20people%20presenting%20to%20healthcare%20settings%20have%20advanced%20HIV%20disease%2C%20with%20no%20evidence%20that%20this%20has%20changed%20in%20recent%20years.%20Screening%20for%20advanced%20HIV%20remains%20important%20to%20be%20able%20to%20direct%20appropriate%20preventive%2C%20diagnostic%20and%20therapeutic%20interventions%20to%20prevent%20progression%20to%20severe%20illness%20and%20death.%20CONCLUSIONS%3A%20This%20review%20summarizes%20recent%20evidence%20of%20the%20continued%20high%20proportion%20of%20individuals%20who%20%28re%29present%20to%20care%20with%20advanced%20HIV%20disease.%20These%20findings%20underscore%20the%20urgent%20need%20to%20reinforce%20programme%20capacity%20to%20diagnose%2C%20prevent%20and%20treat%20advanced%20HIV%20disease%20as%20an%20essential%20pillar%20of%20the%20global%20AIDS%20response.%22%2C%22date%22%3A%222025%20Feb%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26415%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22ZVWK2Q45%22%2C%22D9WC3N3V%22%2C%22TCMBXKKM%22%2C%228IRGNQWZ%22%2C%22F2Y6PLUL%22%2C%22ZBJI578D%22%2C%22YAE5EUBI%22%2C%223FNU2D64%22%5D%2C%22dateModified%22%3A%222025-07-08T08%3A12%3A21Z%22%7D%7D%2C%7B%22key%22%3A%227NGNKLUM%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Banholzer%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMiddelkoop%2C%20Keren%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BLeukes%2C%20Juane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BWeingartner%2C%20Ernest%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSchmutz%2C%20Remo%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Estimating%20Mycobacterium%20tuberculosis%20transmission%20in%20a%20South%20African%20clinic%3A%20Spatiotemporal%20model%20based%20on%20person%20movements.%20%26lt%3Bi%26gt%3BPLoS%20Computational%20Biology%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B21%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e1012823.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012823%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pcbi.1012823%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Estimating%20Mycobacterium%20tuberculosis%20transmission%20in%20a%20South%20African%20clinic%3A%20Spatiotemporal%20model%20based%20on%20person%20movements.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Keren%22%2C%22lastName%22%3A%22Middelkoop%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juane%22%2C%22lastName%22%3A%22Leukes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ernest%22%2C%22lastName%22%3A%22Weingartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Remo%22%2C%22lastName%22%3A%22Schmutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Zurcher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Wood%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22The%20risk%20of%20Mycobacterium%20tuberculosis%20%28Mtb%29%20transmission%20can%20be%20high%20in%20crowded%20clinics.%20We%20developed%20a%20spatiotemporal%20model%20of%20airborne%20Mtb%20transmission%20based%20on%20the%20Wells-Riley%20equation.%20We%20collected%20environmental%2C%20clinical%20and%20person-tracking%20data%20in%20a%20South%20African%20clinic%20during%20COVID-19%2C%20when%20community%20or%20surgical%20masks%20were%20compulsory%20and%20ventilation%20was%20increased.%20We%20matched%20person%20movements%20with%20clinical%20records%20to%20identify%20the%20spatiotemporal%20location%20of%20infectious%20TB%20patients.%20We%20modeled%20the%20concentration%20of%20infectious%20doses%20%28quanta%29%20and%20estimated%20the%20individual%20risk%20of%20infection.%20Over%20five%20days%2C%20video%20sensors%20tracked%201%2C438%20clinic%20attendees.%20CO2%20levels%20were%20low%20%28median%20431%20ppm%2C%20IQR%20406%20ppm-458%20ppm%29%3B%20the%20quanta%20concentration%20was%20higher%20in%20the%20morning%20than%20in%20the%20afternoon%2C%20and%20highest%20in%20the%20waiting%20room.%20The%20estimated%20risk%20of%20infection%20per%20clinic%20attendee%20was%200.05%25%20%2880%25-credible%20interval%20%28CrI%29%200.01%25-0.06%25%29.%20It%20increased%20with%20the%20number%20of%20close%20contacts%20with%20infectious%20patients%20and%20the%20time%20spent%20in%20the%20clinic%2C%20and%20was%201.3-fold%20%2895%25-CrI%201.2-1.4%29%20higher%20in%20scenarios%20without%20mask%20use%20and%202.1-fold%20%2895%25-CrI%200.9-5.0%29%20higher%20with%20pre-pandemic%20ventilation%20rates%2C%20emphasizing%20the%20importance%20of%20ventilation.%20Spatiotemporal%20modeling%20can%20identify%20high-%20risk%20areas%20and%20evaluate%20the%20impact%20of%20infection%20control%20measures%20in%20clinics.%22%2C%22date%22%3A%222025%20Feb%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pcbi.1012823%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221553-7358%201553-734X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-06-16T11%3A43%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22SCPEDY7T%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Anderson%20et%20al.%22%2C%22parsedDate%22%3A%222025-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BAnderson%2C%20Kim%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Helena%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEley%2C%20Brian%20S.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFrigati%2C%20Lisa%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNuttall%2C%20James%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Mother-child%20dyads%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20Undetectable%20%3D%20Undetectable%3F%20%26lt%3Bi%26gt%3BJournal%20of%20the%20International%20AIDS%20Society%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B28%26lt%3B%5C%2Fi%26gt%3B%20%282%29%2C%20S.%20e26418.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26418%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjia2.26418%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mother-child%20dyads%20living%20with%20HIV%20in%20the%20Western%20Cape%2C%20South%20Africa%3A%20Undetectable%20%3D%20Undetectable%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kim%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helena%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20S.%22%2C%22lastName%22%3A%22Eley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Frigati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%22%2C%22lastName%22%3A%22Nuttall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Kalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexa%22%2C%22lastName%22%3A%22Heekes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gayathri%22%2C%22lastName%22%3A%22Sridhar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leigh%22%2C%22lastName%22%3A%22Ragone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vani%22%2C%22lastName%22%3A%22Vannappagari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Mudaly%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Boulle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mary-Ann%22%2C%22lastName%22%3A%22Davies%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Globally%2C%20children%20living%20with%20HIV%20continue%20to%20lag%20behind%20UNAIDS%20targets%20for%20viral%20suppression%20%28VS%29.%20Because%20studies%20with%20linked%20mother-child%20data%20are%20limited%2C%20we%20describe%20VS%20and%20associated%20factors%20among%20young%20children%20in%20a%20setting%20with%20early%20infant%20HIV%20testing%20%28at%20birth%2C%20age%2010%20weeks%20and%206%20months%29%20and%20early%20protease%20inhibitor-based%20first-line%20antiretroviral%20therapy%20%28ART%29.%20METHODS%3A%20We%20analysed%20routinely%20collected%20mother-child%20data%20for%20children%20living%20with%20HIV%20born%202018-2022%20in%20Western%20Cape%20province%2C%20South%20Africa%20%28followed%20through%20mid-2023%29.%20We%20assessed%20associations%20between%20child%20and%20maternal%20viral%20load%20%28VL%29%20results%20at%2012%20and%2024%20months%20after%20child%20ART%20start%20using%20logistic%20regression%2C%20adjusted%20for%20child%20sex%2C%20birthyear%2C%20severity%20of%20child%20immunodeficiency%20at%20ART%20start%2C%20maternal%20age%20and%20timing%20of%20maternal%20HIV%20diagnosis.%20RESULTS%3A%20Among%202219%20children%20living%20with%20HIV%3B%2030%25%20were%20diagnosed%20at%20birth%20%28%26lt%3B%5C%2F%3D7%20days%29%2C%2041%25%20before%20age%201%20year%20%288-365%20days%29%20and%2029%25%20at%20age%20%26gt%3B1%20year.%20Overall%2C%205%25%20%28n%20%3D%20112%5C%2F2219%29%20of%20children%20died%2C%20a%20third%20of%20whom%20had%20not%20started%20ART%3B%2090%25%20of%20children%20%28n%20%3D%201990%29%20started%20ART%2C%20at%20median%20age%205%20months%20%28IQR%201-16%29.%20Median%20follow-up%20from%20ART%20start%20was%2026%20months%20%28IQR%2014-40%29.%20Among%20children%20with%20available%20VL%20at%2012%20months%20%28n%20%3D%20853%5C%2F1582%29%2C%2024%20months%20%28n%20%3D%20614%5C%2F1129%29%20and%2036%20months%20%28n%20%3D%20350%5C%2F658%29%20after%20ART%20start%2C%2036%25%2C%2043%25%20and%2048%25%20were%20virally%20suppressed%2C%20respectively%20%28VL%26lt%3B100%20copies%5C%2Fml%29.%20VS%20among%20children%20at%2012%20and%2024%20months%20was%20more%20likely%20if%20maternal%20VL%20was%20%26lt%3B100%20versus%20%26gt%3B%5C%2F%3D100%20copies%5C%2Fml%20at%2012%20months%20%28adjusted%20odds%20ratio%20%5BaOR%5D%20%3D%203.5%3B%2095%25%20CI%201.9-6.5%29%20and%2024%20months%20%28aOR%20%3D%206.1%3B%2095%25%20CI%202.8-13.1%29%20after%20child%20ART%20start.%20Children%20with%20no%5C%2Fmild%20versus%20advanced%5C%2Fsevere%20immunodeficiency%20at%20ART%20start%20were%20more%20likely%20to%20achieve%20VS%20at%2012%20months%20%28aOR%20%3D%202.3%3B%2095%25%20CI%201.3-4.2%29%20but%20not%20at%2024%20months.%20Eligible%20children%20with%20missing%20VL%20at%2024%20months%20%2839%25%29%20were%20more%20likely%20to%20have%20gaps%20in%20care%20of%20%26gt%3B6%20months%20than%20those%20with%20VL%26gt%3B%5C%2F%3D100%20or%20VL%26lt%3B100%20copies%5C%2Fml%20%2884%25%20vs.%2028%25%20vs.%2014%25%2C%20respectively%3B%20p%26lt%3B0.001%29.%20CONCLUSIONS%3A%20Less%20than%20half%20of%20children%20on%20ART%20achieved%20VS%2C%20and%20children%20were%20more%20likely%20to%20achieve%20VS%20if%20their%20mothers%20were%20also%20virally%20suppressed.%20Significant%20efforts%20are%20needed%20to%20support%20mother-child%20dyads%20to%20achieve%20optimal%20VS.%22%2C%22date%22%3A%222025%20Feb%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fjia2.26418%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221758-2652%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A49%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22LQ46ZRQH%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Didden%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BDidden%2C%20Christiane%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BFolb%2C%20Naomi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMaartens%2C%20Gary%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRohner%2C%20Eliane%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20The%20Contribution%20of%20Noncommunicable%20and%20Infectious%20Diseases%20to%20the%20Effect%20of%20Depression%20on%20Mortality%3A%20A%20Longitudinal%20Causal%20Mediation%20Analysis.%20%26lt%3Bi%26gt%3BEpidemiology%20%28Cambridge%2C%20Mass.%29%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B36%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%2088%26%23x2013%3B98.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FEDE.0000000000001804%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FEDE.0000000000001804%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Contribution%20of%20Noncommunicable%20and%20Infectious%20Diseases%20to%20the%20Effect%20of%20Depression%20on%20Mortality%3A%20A%20Longitudinal%20Causal%20Mediation%20Analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Didden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naomi%22%2C%22lastName%22%3A%22Folb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gary%22%2C%22lastName%22%3A%22Maartens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reshma%22%2C%22lastName%22%3A%22Kassanjee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Mesa-Vieira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ayesha%22%2C%22lastName%22%3A%22Kriel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Soraya%22%2C%22lastName%22%3A%22Seedat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20increased%20prevalence%20of%20physical%20diseases%20among%20individuals%20with%20mental%20illness%20contributes%20to%20their%20increased%20risk%20of%20mortality.%20However%2C%20the%20mediating%20role%20of%20specific%20diseases%20in%20the%20effect%20of%20mental%20illness%20on%20mortality%20is%20not%20well%20understood.%5CnMETHOD%3A%20We%20conducted%20a%20longitudinal%20causal%20mediation%20analysis%20using%20data%20from%20beneficiaries%20of%20a%20South%20African%20medical%20insurance%20scheme%20from%202011%20to%202020.%20We%20estimated%20the%20overall%20effect%20of%20major%20depressive%20disorder%20%28MDD%29%20on%20mortality%20and%20evaluated%20reductions%20in%20this%20overall%20effect%20through%20hypothetical%20interventions%20on%20the%20risks%20of%20mediating%20physical%20diseases%20using%20an%20interventional%20effects%20approach.%20Monte%20Carlo%20simulation-based%20g-computation%20was%20used%20for%20estimation.%5CnRESULTS%3A%20Among%20981%2C540%20individuals%2C%20143%2C314%20%2814.6%25%29%20were%20diagnosed%20with%20MDD.%20Mortality%20risk%20after%208%20years%20was%206.5%25%20under%20MDD%2C%20and%205.3%25%20under%20no%20MDD%20%28risk%20ratio%201.23%2C%2095%25%20CI%20%3D%201.19%2C%201.26%29.%20Overall%2C%2043.4%25%20of%20this%20disparity%20could%20be%20attributed%20to%20higher%20rates%20of%20physical%20comorbidities%20due%20to%20MDD.%20Cardiovascular%20diseases%20accounted%20for%2017.8%25%2C%20followed%20by%20chronic%20respiratory%20diseases%20%288.6%25%29%2C%20cancers%20%287.5%25%29%2C%20diabetes%20and%20chronic%20kidney%20disease%20%285.8%25%29%2C%20tuberculosis%20%284.3%25%29%2C%20and%20HIV%20%282.7%25%29.%5CnCONCLUSION%3A%20Within%20the%20privately%20insured%20population%20of%20South%20Africa%2C%20MDD%20is%20associated%20with%20increased%20mortality.%20We%20found%20that%20noncommunicable%20diseases%2C%20rather%20than%20infectious%20diseases%2C%20are%20important%20mediators%20of%20the%20effect%20of%20MDD%20on%20mortality.%22%2C%22date%22%3A%222025-01-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FEDE.0000000000001804%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221531-5487%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A50Z%22%7D%7D%2C%7B%22key%22%3A%222XD6TBKQ%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Samim%20et%20al.%22%2C%22parsedDate%22%3A%222025-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BSamim%2C%20Daryoush%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMuula%2C%20Guy%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BBanholzer%2C%20Nicolas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BChibomba%2C%20Douglas%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BXulu%2C%20Sihle%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Cardiovascular%20Involvement%20in%20Tuberculosis%20Patients%20Treated%20in%20Southern%20Africa.%20%26lt%3Bi%26gt%3BJACC.%20Advances%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20101427.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacadv.2024.101427%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jacadv.2024.101427%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cardiovascular%20Involvement%20in%20Tuberculosis%20Patients%20Treated%20in%20Southern%20Africa.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daryoush%22%2C%22lastName%22%3A%22Samim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guy%22%2C%22lastName%22%3A%22Muula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Banholzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Douglas%22%2C%22lastName%22%3A%22Chibomba%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sihle%22%2C%22lastName%22%3A%22Xulu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolyn%22%2C%22lastName%22%3A%22Bolton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denise%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Perrig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22De%20Marchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunar%22%2C%22lastName%22%3A%22Gunther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Pilgrim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fenner%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20Tuberculosis%20%28TB%29%20is%20the%20leading%20cause%20of%20death%20among%20people%20with%20HIV%20and%20a%20major%20global%20health%20challenge.%20Subclinical%20cardiovascular%20manifestations%20of%20TB%20are%20poorly%20documented%20in%20high%20TB%20and%20HIV%20burden%20countries.%20Objectives%3A%20The%20purpose%20of%20this%20study%20was%20to%20quantify%20the%20prevalence%20of%20cardiovascular%20involvement%20in%20TB%20patients%20and%20investigate%20changes%20after%20completion%20of%20anti-TB%20treatment.%20Methods%3A%20HIV-positive%20and%20HIV-negative%20patients%20diagnosed%20with%20pulmonary%20TB%20between%20October%202022%20and%20November%202023%20were%20enrolled%20from%202%20tertiary%20care%20hospitals%20in%20Zambia%20and%20South%20Africa.%20Standardized%20transthoracic%20echocardiography%20%28TTE%29%20was%20conducted%20at%20TB%20diagnosis%20and%20after%206%20months%20of%20anti-TB%20treatment.%20Cross-%20sectional%20and%20longitudinal%20analyses%20assessed%20pericardial%20effusion%2C%20thickening%2C%20or%20calcification%2C%20with%20and%20without%20signs%20of%20pericardial%20constriction.%20Results%3A%20A%20total%20of%20286%20TB%20patients%20%28218%20%5B76%25%5D%20men%2C%20109%20%5B38%25%5D%20people%20with%20HIV%2C%20median%20age%2035%20years%29%20underwent%20TTE%20at%20TB%20diagnosis%2C%20of%20whom%20105%20participants%20had%20a%20second%20TTE%20after%20completion%20of%20treatment.%20At%20TB%20diagnosis%2C%20134%20%2847%25%29%20had%20pericardial%20effusions%2C%2086%20%2830%25%29%20thickening%2C%207%20%282%25%29%20calcifications%2C%20103%20%2842%25%29%20signs%20of%20constriction%2C%20and%2013%20%2812%25%29%20had%20definite%20diagnosis%20of%20constriction.%20After%20TB%20treatment%2C%20pericardial%20effusions%20%2847%25%20vs%2016%25%2C%20P%20%26lt%3B%200.001%29%20and%20pericardial%20thickenings%20%2830%25%20vs%2015%25%2C%20P%20%3D%200.002%29%20became%20less%20prevalent.%20Pericardial%20calcifications%20%282%25%20vs%201%25%2C%20P%20%3D%200.4%29%2C%20signs%20of%20constrictions%20%2842%25%20vs%2038%25%2C%20P%20%3D%200.4%29%2C%20and%20definite%20diagnosis%20of%20constriction%20%2812%25%20vs%2014%25%2C%20P%20%3D%200.8%29%20were%20similar.%20Conclusions%3A%20Cardiac%20involvement%20is%20frequent%20in%20newly%20diagnosed%20TB%20patients.%20Early%20pericardial%20changes%20may%20be%20reversed%20with%20anti-TB%20treatment.%20Echocardiographic%20screening%20facilitates%20early%20detection%20and%20timely%20management%20of%20cardiovascular%20involvement%20in%20TB%20patients.%22%2C%22date%22%3A%222025%20Jan%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jacadv.2024.101427%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222772-963X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22KDE2A62W%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haas%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BHaas%2C%20Andreas%20D.%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTlali%2C%20Mpho%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRabie%2C%20Stephan%26lt%3B%5C%2Fspan%26gt%3B%20%26amp%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Is%20suicide%20risk%20100-fold%20higher%20in%20people%20with%20HIV%3F%20A%20critical%20appraisal%20of%20a%20meta-analysis.%20%26lt%3Bi%26gt%3BGeneral%20Psychiatry%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B38%26lt%3B%5C%2Fi%26gt%3B%20%284%29%2C%20S.%20e102210.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fgpsych-2025-102210%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fgpsych-2025-102210%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Is%20suicide%20risk%20100-fold%20higher%20in%20people%20with%20HIV%3F%20A%20critical%20appraisal%20of%20a%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Haas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mpho%22%2C%22lastName%22%3A%22Tlali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Rabie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fgpsych-2025-102210%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222517-729X%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222026-01-15T11%3A33%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22ZL9YGUN8%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rossouw%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRossouw%2C%20Laura%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNgcobo%2C%20Nkosinathi%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BClouse%2C%20Kate%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BNattey%2C%20Cornelius%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BTechnau%2C%20Karl-G%26%23xFC%3Bnter%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Augmenting%20maternal%20clinical%20cohort%20data%20with%20administrative%20laboratory%20dataset%20linkages%3A%20a%20validation%20study.%20%26lt%3Bi%26gt%3BDiscover%20Health%20Systems%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B4%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%20S.%20115.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs44250-025-00298-4%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs44250-025-00298-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Augmenting%20maternal%20clinical%20cohort%20data%20with%20administrative%20laboratory%20dataset%20linkages%3A%20a%20validation%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Rossouw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nkosinathi%22%2C%22lastName%22%3A%22Ngcobo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kate%22%2C%22lastName%22%3A%22Clouse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelius%22%2C%22lastName%22%3A%22Nattey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-G%5Cu00fcnter%22%2C%22lastName%22%3A%22Technau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mhairi%22%2C%22lastName%22%3A%22Maskew%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20use%20of%20big%20data%20and%20large%20language%20models%20in%20healthcare%20can%20play%20a%20key%20role%20in%20improving%20patient%20treatment%20and%20healthcare%20management%2C%20especially%20when%20applied%20to%20large-scale%20administrative%20data.%20A%20major%20challenge%20to%20achieving%20this%20is%20ensuring%20that%20patient%20confidentiality%20and%20personal%20information%20is%20protected.%20One%20way%20to%20overcome%20this%20is%20by%20augmenting%20clinical%20data%20with%20administrative%20laboratory%20dataset%20linkages%20in%20order%20to%20avoid%20the%20use%20of%20demographic%20information.%5CnMETHODS%3A%20We%20explored%20an%20alternative%20method%20to%20examine%20patient%20files%20from%20a%20large%20administrative%20dataset%20in%20South%20Africa%20%28the%20National%20Health%20Laboratory%20Services%2C%20or%20NHLS%29%2C%20by%20linking%20external%20data%20to%20the%20NHLS%20database%20using%20specimen%20barcodes%20associated%20with%20laboratory%20tests.%20This%20provides%20a%20deterministic%20way%20of%20performing%20data%20linkages%20without%20accessing%20demographic%20information.%20In%20this%20paper%2C%20we%20quantify%20the%20performance%20metrics%20of%20this%20approach.%5CnRESULTS%3A%20The%20linkage%20of%20the%20large%20NHLS%20data%20to%20external%20hospital%20data%20using%20specimen%20barcodes%20achieved%20a%2095%25%20success.%20Out%20of%20the%201200%20records%20in%20the%20validation%20sample%2C%2087%25%20were%20exact%20matches%20and%209%25%20were%20matches%20with%20typographic%20correction.%20The%20remaining%205%25%20were%20either%20complete%20mismatches%20or%20were%20due%20to%20duplicates%20in%20the%20administrative%20data.%5CnCONCLUSIONS%3A%20The%20high%20success%20rate%20indicates%20the%20reliability%20of%20using%20barcodes%20for%20linking%20data%20without%20demographic%20identifiers.%20Specimen%20barcodes%20are%20an%20effective%20deterministic%20linkage%20tool%20that%20enable%20creation%20of%20large%20linked%20datasets%20without%20compromising%20confidentiality.%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs44250-025-00298-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222731-7501%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-09-30T14%3A36%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22FG32B8TS%22%2C%22library%22%3A%7B%22id%22%3A2775998%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metekoua%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3B%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMetekoua%2C%20Carole%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BRuffieux%2C%20Yann%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BMwansa-Kambafwile%2C%20Judith%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BKellett%2C%20Peter%26lt%3B%5C%2Fspan%26gt%3B%3B%20%26lt%3Bspan%20style%3D%26quot%3Btext-decoration%3Anone%3B%26quot%3B%26gt%3BEgger%2C%20Matthias%26lt%3B%5C%2Fspan%26gt%3B%20et%20al.%26lt%3B%5C%2Fspan%26gt%3B%20%282025%29.%20Patterns%20of%20incident%20Burkitt%20lymphoma%20during%20the%20HIV%20epidemic%20among%20the%20Black%20African%20and%20White%20population%20in%20South%20Africa.%20%26lt%3Bi%26gt%3BBr%20J%20Cancer%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-024-02937-8%26%23039%3B%26gt%3Bhttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41416-024-02937-8%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patterns%20of%20incident%20Burkitt%20lymphoma%20during%20the%20HIV%20epidemic%20among%20the%20Black%20African%20and%20White%20population%20in%20South%20Africa%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carole%22%2C%22lastName%22%3A%22Metekoua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yann%22%2C%22lastName%22%3A%22Ruffieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Mwansa-Kambafwile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Kellett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Egger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mazvita%22%2C%22lastName%22%3A%22Muchengeti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eliane%22%2C%22lastName%22%3A%22Rohner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tracey%22%2C%22lastName%22%3A%22Wiggill%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41416-024-02937-8%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22GXCKG69T%22%2C%22TCMBXKKM%22%5D%2C%22dateModified%22%3A%222025-04-03T11%3A48%3A36Z%22%7D%7D%5D%7D
Banholzer, Nicolas; Muula, Guy; Mureithi, Fiona; Banda, Esau; Bittel, Pascal et al. (2025). Reducing spatial clustering to prevent tuberculosis transmission in a busy Zambian hospital: a modelling study based on person movements, environmental and clinical data. medRxiv: The Preprint Server for Health Sciences, S. 2025.12.24.25342956. http://doi.org/10.64898/2025.12.24.25342956.
de Beer, Shani T.; Phelanyane, Florence; Ingle, Suzanne M.; Slogrove, Amy L.; Eley, Brian S. et al. (2025). Infectious-cause hospitalisation in a province-wide cohort of children with antenatal HIV exposure compared to children without HIV exposure. AIDS (London, England). http://doi.org/10.1097/QAD.0000000000004423.
Pan, Zhongzhe; Brazier, Ellen; Duda, Stephany N.; Ross, Jeremy; Templeton, David J. et al. (2025). Limited user fees for adult HIV diagnosis and routine laboratory monitoring in the global IeDEA consortium: analysis in 42 countries. medRxiv: The Preprint Server for Health Sciences, S. 2025.12.05.25341715. http://doi.org/10.64898/2025.12.05.25341715.
Han, Nuri; Loosli, Tom; Anderegg, Nanina; Hauser, Anthony; Josi, Johannes et al. (2025). The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study. The Lancet. Global Health, 13 (12), S. e2133–e2143. http://doi.org/10.1016/S2214-109X(25)00350-X.
Motlokwa, Precious Kefilwe; Ruffieux, Yann; Chinogurei, Chido; Haas, Andreas D.; Folb, Naomi et al. (2025). Survival among medically insured and treated head and neck cancer patients with and without HIV in South Africa. HIV Medicine, 26 (12), S. 1973–1982. http://doi.org/10.1111/hiv.70143.
Fernández Villalobos, Nathalie V.; Ruffieux, Yann; Chinogurei, Chido; Haas, Andreas D.; Low, Nicola et al. (2025). Immunodeficiency, HIV Viremia, and Incident Anal Cancer Among People With HIV in South Africa. Open Forum Infectious Diseases, 12 (12), S. ofaf693. http://doi.org/10.1093/ofid/ofaf693.
Brazier, Ellen; Berry, Amanda; Katz, Benjamin; Lewis, Judith T.; Duda, Stephany N. et al. (2025). The development of IeDEA’s Treat All Dashboard on HIV care outcomes at participating clinics in Sub-Saharan Africa. medRxiv: The Preprint Server for Health Sciences, S. 2025.11.20.25340413. http://doi.org/10.1101/2025.11.20.25340413.
Andoh, John; Taghavi, Katayoun; Moono, Misinzo; Basu, Partha; Madliwa, Thamsanqa et al. (2025). Cervical intraepithelial neoplasia progression and regression among women living with HIV in Zambia. HIV Medicine. http://doi.org/10.1111/hiv.70134.
Vreeman, Rachel C.; Yiannoutsos, Constantin T.; Edmonds, Andrew; Leroy, Valériane; Fatti, Geoffrey et al. (2025). Rates of adherence, adherence measurement, and support services for children and adolescents living with HIV followed in global sites of the International Epidemiology Databases to Evaluate AIDS (IeDEA). BMC Pediatrics, 25 (1), S. 706. http://doi.org/10.1186/s12887-025-05939-4.
Keal, Josephine; van Dongen, Nicola; Ferreria, Thalia; Sorour, Gillian & Technau, Karl-Günter (2025). Care for the Caregiver: How Caregiver Mortality Affects Treatment Outcomes-An Observational Cohort Study. AIDS and Behavior, 29 (10), S. 3087–3094. http://doi.org/10.1007/s10461-025-04760-5.
Skrivankova, Veronika Whitesell; Rabie, Stephan; Tlali, Mpho; Folb, Naomi; Chinogurei, Chido et al. (2025). Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study. PLoS Medicine, 22 (9), S. e1004765. http://doi.org/10.1371/journal.pmed.1004765.
Anderson, Kim; Madlala, Hlengiwe P.; Nyemba, Dorothy C.; Dinkele, Ryan; Smith, Mariette et al. (2025). Infectious morbidity among children HIV-exposed uninfected in South Africa: elevated risk in infancy but not thereafter. AIDS (London, England). http://doi.org/10.1097/QAD.0000000000004358.
Fernández Villalobos, Nathalie Verónica; Ruffieux, Yann; Chinogurei, Chido; Haas, Andreas D.; Low, Nicola et al. (2025). Anal Cancer Incidence Rates Among Men and Women With and Without HIV in South Africa. Open Forum Infectious Diseases, 12 (9), S. ofaf537. http://doi.org/10.1093/ofid/ofaf537.
Phillips, Tamsin K.; Gomba, Yolanda; Mogoba, Pheposadi; Phelanyane, Florence; Anderson, Kim et al. (2025). Routine Electronic Mother-Infant Data (REMInD): A proof-of-Concept Data to Care Study to Support Retention in Maternal HIV Treatment and Infant HIV Testing in Cape Town, South Africa. AIDS and Behavior, 29 (9), S. 2689–2700. http://doi.org/10.1007/s10461-025-04726-7.
Banholzer, Nicolas; Muula, Guy; Mureithi, Fiona; Evans, Denise; Huwa, Jacqueline et al. (2025). Mental, physical, and respiratory health in people with tuberculosis in Southern Africa: a multi-country cohort analysis. BMC Medicine, 23 (1), S. 485. http://doi.org/10.1186/s12916-025-04321-6.
Benade, Mariet; Maskew, Mhairi; Chilembo, Phillip; Wa Mwansa, Mwansa; Savory, Theodora et al. (2025). Patterns of engagement in care during clients’ first 12 months after HIV treatment initiation in Zambia: a retrospective cohort analysis using routinely collected data. BMJ Global Health, 10 (8), S. e017930. http://doi.org/10.1136/bmjgh-2024-017930.
Ruffieux, Yann; Joska, John A.; Lang, Raynell; Zheng, Chunyan; Folb, Naomi et al. (2025). Life-years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States. Journal of the International AIDS Society, 28 (8), S. e70023. http://doi.org/10.1002/jia2.70023.
Gastaldon, C.; Whitesell Skrivankova, V.; Schoretsanitis, G.; Folb, N.; Taghavi, K. et al. (2025). Diagnosis of postpartum depression and associated factors in South Africa: a cohort study of 47,697 women. Epidemiology and Psychiatric Sciences, 34, S. e41. http://doi.org/10.1017/S2045796025100103.
Fernández Villalobos, Nathalie Verónica; Helfenstein, Fabrice; Khol, Vohith; Twizere, Christella; Secco, Mayara et al. (2025). Scale of differentiated service delivery implementation in HIV care facilities in low- and middle-income countries: a global facility survey. Journal of the International AIDS Society, 28 Suppl 3, S. e26477. http://doi.org/10.1002/jia2.26477.
Banholzer, Nicolas; Middelkoop, Keren; Schmutz, Remo; Leukes, Juane; Zürcher, Kathrin et al. (2025). Infection prevention and control measures during the COVID-19 pandemic and airborne tuberculosis transmission during primary care visits in South Africa. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 156, S. 107921. http://doi.org/10.1016/j.ijid.2025.107921.
Patten, Gabriela; Haas, Andreas D.; Davies, Mary-Ann; Maartens, Gary; Chinogurei, Chido et al. (2025). Association between changes in script renewal periods and HIV viral non-suppression: a cohort study of a South African private-sector HIV program. Journal of Acquired Immune Deficiency Syndromes (1999). http://doi.org/10.1097/QAI.0000000000003697.
Anderson, Kim; Rabie, Helena; Eley, Brian S.; Frigati, Lisa; Nuttall, James et al. (2025). High Incidence of Tuberculosis in Young Children Living With HIV in the Western Cape, South Africa. Journal of Acquired Immune Deficiency Syndromes (1999), 98 (5), S. 506–514. http://doi.org/10.1097/QAI.0000000000003591.
Patten, Gabriela; Malateste, Karen; Bolton Moore, Carolyn; Sipambo, Nosisa; Mokone, Limpho et al. (2025). Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV. The Pediatric Infectious Disease Journal. http://doi.org/10.1097/INF.0000000000004819.
Embleton, Lonnie; Sudjaritruk, Tavitiya; Machado, Daisy Maria; Chihota, Belinda; Musabyimana, Françoise et al. (2025). Characterizing adolescent and youth-friendly HIV services: a cross-sectional assessment across 16 global sites. Journal of the International AIDS Society, 28 (4), S. e26437. http://doi.org/10.1002/jia2.26437.
Ballif, Marie; Banholzer, Nicolas; Perrig, Lisa; Avihingsanon, Anchalee; Nsonde, Dominique Mahambu et al. (2025). The long-term impact of the COVID-19 pandemic on tuberculosis care and infection control measures in anti-retroviral therapy (ART) clinics in low- and middle-income countries: a multiregional site survey in Asia and Africa. BMJ Global Health, 10 (3), S. e017828. http://doi.org/10.1136/bmjgh-2024-017828.
Anderson, Kim; Eley, Brian S.; Rabie, Helena; Muloiwa, Rudzani; Nuttall, James et al. (2025). Hospitalisation incidence among young children living with HIV in the Western Cape, South Africa. AIDS (London, England). http://doi.org/10.1097/QAD.0000000000004156.
Schwab, Tiana C.; Joseph, Lavania; Moono, Andrew; Göller, Pauline C.; Motsei, Mamello et al. (2025). Field evaluation of nanopore targeted next-generation sequencing to predict drug-resistant tuberculosis from native sputum in South Africa and Zambia. Journal of Clinical Microbiology, 63 (3), S. e0139024. http://doi.org/10.1128/jcm.01390-24.
Chihota, Belinda Varaidzo; Mandiriri, Ardele; Muula, Guy; Banda, Esau; Shamu, Tinei et al. (2025). Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort). BMJ Open, 15 (2), S. e088706. http://doi.org/10.1136/bmjopen-2024-088706.
Ford, Nathan; Kassanjee, Reshma; Stelzle, Dominik; Jarvis, Joseph N.; Sued, Omar et al. (2025). Global prevalence of advanced HIV disease in healthcare settings: a rapid review. Journal of the International AIDS Society, 28 (2), S. e26415. http://doi.org/10.1002/jia2.26415.
Banholzer, Nicolas; Middelkoop, Keren; Leukes, Juane; Weingartner, Ernest; Schmutz, Remo et al. (2025). Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements. PLoS Computational Biology, 21 (2), S. e1012823. http://doi.org/10.1371/journal.pcbi.1012823.
Anderson, Kim; Rabie, Helena; Eley, Brian S.; Frigati, Lisa; Nuttall, James et al. (2025). Mother-child dyads living with HIV in the Western Cape, South Africa: Undetectable = Undetectable? Journal of the International AIDS Society, 28 (2), S. e26418. http://doi.org/10.1002/jia2.26418.
Didden, Christiane; Egger, Matthias; Folb, Naomi; Maartens, Gary; Rohner, Eliane et al. (2025). The Contribution of Noncommunicable and Infectious Diseases to the Effect of Depression on Mortality: A Longitudinal Causal Mediation Analysis. Epidemiology (Cambridge, Mass.), 36 (1), S. 88–98. http://doi.org/10.1097/EDE.0000000000001804.
Samim, Daryoush; Muula, Guy; Banholzer, Nicolas; Chibomba, Douglas; Xulu, Sihle et al. (2025). Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa. JACC. Advances, 4 (1), S. 101427. http://doi.org/10.1016/j.jacadv.2024.101427.
Haas, Andreas D.; Ruffieux, Yann; Tlali, Mpho; Rabie, Stephan & Egger, Matthias (2025). Is suicide risk 100-fold higher in people with HIV? A critical appraisal of a meta-analysis. General Psychiatry, 38 (4), S. e102210. http://doi.org/10.1136/gpsych-2025-102210.
Rossouw, Laura; Ngcobo, Nkosinathi; Clouse, Kate; Nattey, Cornelius; Technau, Karl-Günter et al. (2025). Augmenting maternal clinical cohort data with administrative laboratory dataset linkages: a validation study. Discover Health Systems, 4 (1), S. 115. http://doi.org/10.1007/s44250-025-00298-4.
Metekoua, Carole; Ruffieux, Yann; Mwansa-Kambafwile, Judith; Kellett, Peter; Egger, Matthias et al. (2025). Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa. Br J Cancer. http://doi.org/10.1038/s41416-024-02937-8.
Contact Us